1DXA

BENZO[A]PYRENE DIOL EPOXIDE ADDUCT OF DA IN DUPLEX DNA

1DXA の概要

• エントリーDOI: 10.2210/pdb1dxa/pdb
• 分子名称: DNA (5'-D(*GP*GP*TP*CP*AP*CP*GP*AP*G)-3'), DNA (5'-D(*CP*TP*CP*GP*GP*GP*AP*CP*C)-3'), 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE (3 entities in total)
• 機能のキーワード: double helix, benzo[a]pyrene diol epoxide adduct, duplex dna, non-watson-crick base pair, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 5801.96

構造登録者

Yeh, H.J.C.,Sayer, J.M.,Liu, X.,Altieri, A.S.,Byrd, R.A.,Lakshman, M.K.,Yagi, H.,Schurter, E.J.,Gorenstein, D.G.,Jerina, D.M. (登録日: 1995-09-01, 公開日: 1995-12-07, 最終更新日: 2024-03-13)

• 主引用文献: Yeh, H.J.,Sayer, J.M.,Liu, X.,Altieri, A.S.,Byrd, R.A.,Lakshman, M.K.,Yagi, H.,Schurter, E.J.,Gorenstein, D.G.,Jerina, D.M.; NMR solution structure of a nonanucleotide duplex with a dG mismatch opposite a 10S adduct derived from trans addition of a deoxyadenosine N6-amino group to (+)-(7R,8S,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene: an unusual syn glycosidic torsion angle at the modified dA; Biochemistry, 34:13570-13581, 1995; PubMed: 7577946; DOI: 10.1021/bi00041a037

実験手法

SOLUTION NMR