1DSA

(+)-DUOCARMYCIN SA COVALENTLY LINKED TO DUPLEX DNA, NMR, 20 STRUCTURES

1DSA の概要

• エントリーDOI: 10.2210/pdb1dsa/pdb
• 分子名称: DNA (5'-D(*GP*AP*CP*TP*AP*AP*TP*TP*GP*AP*C)-3', 5'-D(*GP*TP*CP*AP*AP*TP*TP*AP*GP*TP*C)-3'), 4-HYDROXY-8-METHYL-6-(4,5,6-TRIMETHOXY-1H-INDOLE-2-CARBONYL)-3,6,7,8-TETRAHYDRO-3,6-DIAZA-AS-INDACENE-2-CARBOXYLIC ACID METHYL ESTER (3 entities in total)
• 機能のキーワード: duocarmycin, dna, minor groove binding, antitumor agent, drug-dna complex, deoxyribonucleic acid
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7184.91

構造登録者

Eis, P.S.,Smith, J.A.,Case, D.A.,Chazin, W.J. (登録日: 1997-05-08, 公開日: 1997-08-20, 最終更新日: 2022-02-16)

• 主引用文献: Eis, P.S.,Smith, J.A.,Rydzewski, J.M.,Case, D.A.,Boger, D.L.,Chazin, W.J.; High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA.; J.Mol.Biol., 272:237-252, 1997; PubMed: 9299351; DOI: 10.1006/jmbi.1997.1223

実験手法

SOLUTION NMR