1DB5

HUMAN S-PLA2 IN COMPLEX WITH INDOLE 6

Summary for 1DB5

Entry DOI	10.2210/pdb1db5/pdb
Related	1DB4 1DCY
Descriptor	PROTEIN (PHOSPHOLIPASE A2), CALCIUM ION, 4-(1-BENZYL-3-CARBAMOYLMETHYL-2-METHYL-1H-INDOL-5-YLOXY)-BUTYRIC ACID, ... (4 entities in total)
Functional Keywords	s-pla2; structure-based drug design, hydrolase/hydrolase inhibitor, hydrolase-hydrolase inhibitor complex
Biological source	Homo sapiens (human)
Cellular location	Membrane; Peripheral membrane protein: P14555
Total number of polymer chains	1
Total formula weight	14405.61
Authors	Chirgadze, N.Y.,Schevitz, R.W.,Wery, J.-P. (deposition date: 1999-11-02, release date: 1999-11-12, Last modification date: 2012-02-29)
Primary citation	Schevitz, R.W.,Bach, N.J.,Carlson, D.G.,Chirgadze, N.Y.,Clawson, D.K.,Dillard, R.D.,Draheim, S.E.,Hartley, L.W.,Jones, N.D.,Mihelich, E.D.,Olkowski, J.L.,Snyder, D.W.,Sommers, C.,Wery, J.-P. Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2. Nat.Struct.Biol., 2:458-465, 1995 Cited by PubMed: 7664108 DOI: 10.1038/nsb0695-458 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation