1D6N

TERNARY COMPLEX STRUCTURE OF HUMAN HGPRTASE, PRPP, MG2+, AND THE INHIBITOR HPP REVEALS THE INVOLVEMENT OF THE FLEXIBLE LOOP IN SUBSTRATE BINDING

1D6N の概要

• エントリーDOI: 10.2210/pdb1d6n/pdb
• 分子名称: PROTEIN (HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE), MAGNESIUM ION, 3H-PYRAZOLO[4,3-D]PYRIMIDIN-7-OL, ... (5 entities in total)
• 機能のキーワード: hgprtase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00492
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49144.19

構造登録者

Balendiran, G.K. (登録日: 1999-10-14, 公開日: 1999-12-30, 最終更新日: 2024-02-07)

• 主引用文献: Balendiran, G.K.,Molina, J.A.,Xu, Y.,Torres-Martinez, J.,Stevens, R.,Focia, P.J.,Eakin, A.E.,Sacchettini, J.C.,Craig III, S.P.; Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding.; Protein Sci., 8:1023-1031, 1999; PubMed: 10338013

実験手法

X-RAY DIFFRACTION (2.7 Å)