1D36

FACILE FORMATION OF A CROSSLINKED ADDUCT BETWEEN DNA AND THE DAUNORUBICIN DERIVATIVE MAR70 MEDIATED BY FORMALDEHYDE: MOLECULAR STRUCTURE OF THE MAR70-D(CGTNACG) COVALENT ADDUC

Summary for 1D36

• Entry DOI: 10.2210/pdb1d36/pdb
• Descriptor: DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), 4'-EPI-4'-(2-DEOXYFUCOSE)DAUNOMYCIN, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: right handed dna, double helix, complexed with drug, dna
• Total number of polymer chains: 1
• Total formula weight: 2491.18

Authors

Gao, Y.-G.,Liaw, Y.-C.,Li, Y.-K.,Van Der Marel, G.A.,Van Boom, J.H.,Wang, A.H.-J. (deposition date: 1991-04-23, release date: 1992-04-15, Last modification date: 2024-02-07)

• Primary citation: Gao, Y.G.,Liaw, Y.C.,Li, Y.K.,van der Marel, G.A.,van Boom, J.H.,Wang, A.H.; Facile formation of a crosslinked adduct between DNA and the daunorubicin derivative MAR70 mediated by formaldehyde: molecular structure of the MAR70-d(CGTnACG) covalent adduct.; Proc.Natl.Acad.Sci.USA, 88:4845-4849, 1991; PubMed: 2052564; DOI: 10.1073/pnas.88.11.4845

Experimental method

X-RAY DIFFRACTION (1.5 Å)