1D35

FACILE FORMATION OF A CROSSLINKED ADDUCT BETWEEN DNA AND THE DAUNORUBICIN DERIVATIVE MAR70 MEDIATED BY FORMALDEHYDE: MOLECULAR STRUCTURE OF THE MAR70-D(CGTNACG) COVALENT ADDUC

1D35 の概要

• エントリーDOI: 10.2210/pdb1d35/pdb
• 分子名称: DNA (5'-D(*CP*GP*TP*(A40)P*CP*G)-3'), 4'-EPI-4'-(2-DEOXYFUCOSE)DAUNOMYCIN, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: right handed dna, double helix, complexed with drug, modified, dna
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2520.22

構造登録者

Gao, Y.-G.,Liaw, Y.-C.,Li, Y.-K.,Van Der Marel, G.A.,Van Boom, J.H.,Wang, A.H.-J. (登録日: 1991-04-23, 公開日: 1992-04-15, 最終更新日: 2024-02-07)

• 主引用文献: Gao, Y.G.,Liaw, Y.C.,Li, Y.K.,van der Marel, G.A.,van Boom, J.H.,Wang, A.H.; Facile formation of a crosslinked adduct between DNA and the daunorubicin derivative MAR70 mediated by formaldehyde: molecular structure of the MAR70-d(CGTnACG) covalent adduct.; Proc.Natl.Acad.Sci.USA, 88:4845-4849, 1991; PubMed: 2052564; DOI: 10.1073/pnas.88.11.4845

実験手法

X-RAY DIFFRACTION (1.3 Å)