1CSJ

CRYSTAL STRUCTURE OF THE RNA-DEPENDENT RNA POLYMERASE OF HEPATITIS C VIRUS

1CSJ の概要

• エントリーDOI: 10.2210/pdb1csj/pdb
• 分子名称: HEPATITIS C VIRUS RNA POLYMERASE (NS5B) (2 entities in total)
• 機能のキーワード: polyprotein, glycoprotein, rna-directed rna polymerase, core protein, coat protein, envelope protein, helicase, atp-binding, transmembrane, nonstructural protein, transferase
• 由来する生物種: Hepatitis C virus
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 118892.50

構造登録者

Bressanelli, S.,Tomei, L.,Roussel, A.,Incitti, I.,Vitale, R.L.,Mathieu, M.,De Francesco, R.,Rey, F.A. (登録日: 1999-08-18, 公開日: 1999-11-08, 最終更新日: 2013-02-13)

• 主引用文献: Bressanelli, S.,Tomei, L.,Roussel, A.,Incitti, I.,Vitale, R.L.,Mathieu, M.,De Francesco, R.,Rey, F.A.; Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus.; Proc.Natl.Acad.Sci.USA, 96:13034-13039, 1999; PubMed: 10557268; DOI: 10.1073/pnas.96.23.13034

実験手法

X-RAY DIFFRACTION (2.8 Å)