1CD2

LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+

1CD2 の概要

• エントリーDOI: 10.2210/pdb1cd2/pdb
• 分子名称: DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, FOLIC ACID, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, one-carbon metabolism
• 由来する生物種: Pneumocystis carinii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25103.34

構造登録者

Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Blakley, R.L.,Gangjee, A. (登録日: 1999-03-05, 公開日: 2000-03-06, 最終更新日: 2023-08-09)

• 主引用文献: Cody, V.,Galitsky, N.,Rak, D.,Luft, J.R.,Pangborn, W.,Queener, S.F.; Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+.; Biochemistry, 38:4303-4312, 1999; PubMed: 10194348; DOI: 10.1021/bi982728m

実験手法

X-RAY DIFFRACTION (2.2 Å)