1CA0

BOVINE CHYMOTRYPSIN COMPLEXED TO APPI

1CA0 の概要

• エントリーDOI: 10.2210/pdb1ca0/pdb
• 分子名称: BOVINE CHYMOTRYPSIN, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR, ... (5 entities in total)
• 機能のキーワード: serine protease, inhibitor, protease-substrate interactions, complex (serine protease-inhibitor), complex (serine protease-inhibitor) complex, complex (serine protease/inhibitor)
• 由来する生物種: Bos taurus (cattle); 詳細
• 細胞内の位置: Secreted, extracellular space: P00766 P00766 P00766; Membrane; Single-pass type I membrane protein: P05067
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 62536.46

構造登録者

Scheidig, A.J.,Kossiakoff, A.A. (登録日: 1997-01-23, 公開日: 1997-07-23, 最終更新日: 2011-07-13)

• 主引用文献: Scheidig, A.J.,Hynes, T.R.,Pelletier, L.A.,Wells, J.A.,Kossiakoff, A.A.; Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.; Protein Sci., 6:1806-1824, 1997; PubMed: 9300481

実験手法

X-RAY DIFFRACTION (2.1 Å)