1C9D

CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-HYDROXY-4-FLUOROPHENYLTHIO)-BUTYLPHOSPHONIC ACID

Summary for 1C9D

• Entry DOI: 10.2210/pdb1c9d/pdb
• Related: 1C29 1C8V
• Descriptor: TRYPTOPHAN SYNTHASE (ALPHA CHAIN), TRYPTOPHAN SYNTHASE (BETA CHAIN), 4-(2-HYDROXY-4-FLUOROPHENYLTHIO)-BUTYLPHOSPHONIC ACID, ... (6 entities in total)
• Functional Keywords: 8-fold alpha-beta barrel, enzyme-inhibitor complex, lyase
• Biological source: Salmonella typhimurium; More
• Total number of polymer chains: 2
• Total formula weight: 72236.16

Authors

Lolis, E.,Sachpatzidis, A. (deposition date: 1999-08-02, release date: 1999-12-29, Last modification date: 2024-03-13)

• Primary citation: Sachpatzidis, A.,Dealwis, C.,Lubetsky, J.B.,Liang, P.H.,Anderson, K.S.,Lolis, E.; Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase.; Biochemistry, 38:12665-12674, 1999; PubMed: 10504236; DOI: 10.1021/bi9907734

Experimental method

X-RAY DIFFRACTION (2.3 Å)