1C5Y

STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR

1C5Y の概要

• エントリーDOI: 10.2210/pdb1c5y/pdb
• 分子名称: PROTEIN (UROKINASE-TYPE PLASMINOGEN ACTIVATOR), CITRATE ANION, THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDINE, ... (5 entities in total)
• 機能のキーワード: selective, s1 site inhibitor, structure-based drug design, urokinase, trypsin, thrombin, blood clotting
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00749 P00749
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31889.15

構造登録者

Katz, B.A.,Mackman, R.,Luong, C.,Radika, K.,Martelli, A.,Sprengeler, P.A.,Wang, J.,Chan, H.,Wong, L. (登録日: 1999-12-22, 公開日: 2000-12-22, 最終更新日: 2024-04-03)

• 主引用文献: Katz, B.A.,Mackman, R.,Luong, C.,Radika, K.,Martelli, A.,Sprengeler, P.A.,Wang, J.,Chan, H.,Wong, L.; Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.; Chem.Biol., 7:299-312, 2000; PubMed: 10779411; DOI: 10.1016/S1074-5521(00)00104-6

実験手法

X-RAY DIFFRACTION (1.65 Å)