1BX6

CRYSTAL STRUCTURE OF THE POTENT NATURAL PRODUCT INHIBITOR BALANOL IN COMPLEX WITH THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE

1BX6 の概要

• エントリーDOI: 10.2210/pdb1bx6/pdb
• 分子名称: CAMP-DEPENDENT PROTEIN KINASE, BALANOL (3 entities in total)
• 機能のキーワード: serine/threonine-protein kinase, balanol, conformational changes, inhibition, protein kinase pka, serine-threonine-protein kinase complex
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Cytoplasm (By similarity): P05132
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41287.81

構造登録者

Narayana, N.,Xuong, N.-H.,Ten Eyck, L.F.,Taylor, S.S. (登録日: 1998-10-13, 公開日: 1999-04-27, 最終更新日: 2023-08-09)

• 主引用文献: Narayana, N.,Diller, T.C.,Koide, K.,Bunnage, M.E.,Nicolaou, K.C.,Brunton, L.L.,Xuong, N.H.,Ten Eyck, L.F.,Taylor, S.S.; Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase.; Biochemistry, 38:2367-2376, 1999; PubMed: 10029530; DOI: 10.1021/bi9820659

実験手法

X-RAY DIFFRACTION (2.1 Å)