1BQM
HIV-1 RT/HBY 097
Summary for 1BQM
| Entry DOI | 10.2210/pdb1bqm/pdb |
| Descriptor | REVERSE TRANSCRIPTASE, (S)-4-ISOPROPOXYCARBONYL-6-METHOXY-3-METHYLTHIOMETHYL-3,4-DIHYDROQUINOXALIN-2(1H)-THIONE (3 entities in total) |
| Functional Keywords | nucleotidyltransferase, aids, rna-directed dna polymerase, hiv-1 rt/hby 097, drug-resistant mutant |
| Biological source | Human immunodeficiency virus 1 More |
| Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
| Total number of polymer chains | 2 |
| Total formula weight | 114610.50 |
| Authors | Hsiou, Y.,Das, K.,Ding, J.,Arnold, E. (deposition date: 1998-08-17, release date: 1999-01-06, Last modification date: 2023-08-09) |
| Primary citation | Hsiou, Y.,Das, K.,Ding, J.,Clark Jr., A.D.,Kleim, J.P.,Rosner, M.,Winkler, I.,Riess, G.,Hughes, S.H.,Arnold, E. Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance. J.Mol.Biol., 284:313-323, 1998 Cited by PubMed: 9813120DOI: 10.1006/jmbi.1998.2171 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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