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1BQI

USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN K INHIBITORS. CRYSTAL STRUCTURES OF TWO PAPAIN INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES.

Summary for 1BQI
Entry DOI10.2210/pdb1bqi/pdb
DescriptorPAPAIN, CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE (3 entities in total)
Functional Keywordshydrolase, sulfhydryl proteinase, papain
Biological sourceCarica papaya (papaya)
Total number of polymer chains1
Total formula weight23857.88
Authors
Lalonde, J.M.,Zhao, B.,Smith, W.W.,Janson, C.A.,Desjarlais, R.L.,Tomaszek, T.A.,Carr, T.J.,Thompson, S.K.,Yamashita, D.S.,Veber, D.F.,Abdel-Mequid, S.S. (deposition date: 1998-08-16, release date: 1999-08-16, Last modification date: 2023-08-09)
Primary citationLaLonde, J.M.,Zhao, B.,Smith, W.W.,Janson, C.A.,DesJarlais, R.L.,Tomaszek, T.A.,Carr, T.J.,Thompson, S.K.,Oh, H.J.,Yamashita, D.S.,Veber, D.F.,Abdel-Meguid, S.S.
Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites.
J.Med.Chem., 41:4567-4576, 1998
Cited by
PubMed: 9804696
DOI: 10.1021/jm980249f
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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