1B9V

NOVEL AROMATIC INHIBITORS OF INFLUENZA VIRUS NEURAMINIDASE MAKE SELECTIVE INTERACTIONS WITH CONSERVED RESIDUES AND WATER MOLECULES IN TEH ACTIVE SITE

Summary for 1B9V

Entry DOI	10.2210/pdb1b9v/pdb
Descriptor	PROTEIN (NEURAMINIDASE), 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (5 entities in total)
Functional Keywords	influenza, neuraminidase, sialidase, b/lee/40, hydrolase
Biological source	Influenza B virus (B/Lee/40)
Cellular location	Virion membrane (By similarity): P03474
Total number of polymer chains	1
Total formula weight	44112.12
Authors	Finley, J.B.,Atigadda, V.R.,Duarte, F.,Zahao, J.J.,Brouillette, W.J.,Air, G.M.,Luo, M. (deposition date: 1999-02-15, release date: 1999-02-27, Last modification date: 2023-08-09)
Primary citation	Finley, J.B.,Atigadda, V.R.,Duarte, F.,Zhao, J.J.,Brouillette, W.J.,Air, G.M.,Luo, M. Novel aromatic inhibitors of influenza virus neuraminidase make selective interactions with conserved residues and water molecules in the active site. J.Mol.Biol., 293:1107-1119, 1999 Cited by PubMed: 10547289 DOI: 10.1006/jmbi.1999.3180 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation