1B0S

BINDING OF AR-1-144, A TRI-IMIDAZOLE DNA MINOR GROOVE BINDER, TO CCGG SEQUENCE ANALYZED BY NMR SPECTROSCOPY

Summary for 1B0S

• Entry DOI: 10.2210/pdb1b0s/pdb
• NMR Information: BMRB: 4392
• Descriptor: DNA (5'-D(*GP*AP*AP*CP*CP*GP*GP*TP*TP*C)-3'), (2-{[4-({4-[(4-FORMYLAMINO-1-METHYL-1H-IMIDAZOLE-2-CARBONYL)-AMINO]-1-METHYL-1H-IMIDAZOLE-2-CARBONYL}-AMINO)-1-METHYL-1 H-IMIDAZOLE-2-CARBONYL]-AMINO}-ETHYL)-DIMETHYL-AMMONIUM (2 entities in total)
• Functional Keywords: anticancer drug, drug design, dna structure, sequence specific recognition, dna
• Total number of polymer chains: 2
• Total formula weight: 7063.03

Authors

Yang, X.-L.,Kaenzig, C.,Lee, M.,Wang, A.H.-J. (deposition date: 1998-11-12, release date: 1999-08-31, Last modification date: 2023-12-27)

• Primary citation: Yang, X.L.,Kaenzig, C.,Lee, M.,Wang, A.H.; Binding of AR-1-144, a tri-imidazole DNA minor groove binder, to CCGG sequence analyzed by NMR spectroscopy.; Eur.J.Biochem., 263:646-655, 1999; PubMed: 10469127; DOI: 10.1046/j.1432-1327.1999.00515.x

Experimental method

SOLUTION NMR