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1B0F

CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL ELASTASE WITH MDL 101, 146

Summary for 1B0F
Entry DOI10.2210/pdb1b0f/pdb
DescriptorPROTEIN (ELASTASE), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 1-{3-METHYL-2-[4-(MORPHOLINE-4-CARBONYL)-BENZOYLAMINO]-BUTYRYL}-PYRROLIDINE-2-CARBOXYLIC ACID (3,3,4,4,4-PENTAFLUORO-1-ISOPROPYL-2-OXO-BUTYL)-AMIDE, ... (4 entities in total)
Functional Keywordsserine protease, fluoroethyl ketones, hydrolase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight25007.55
Authors
Schreuder, H.A.,Metz, W.A.,Peet, N.P.,Pelton, J.T.,Tardif, C. (deposition date: 1998-11-09, release date: 1998-11-09, Last modification date: 2023-08-09)
Primary citationCregge, R.J.,Durham, S.L.,Farr, R.A.,Gallion, S.L.,Hare, C.M.,Hoffman, R.V.,Janusz, M.J.,Kim, H.O.,Koehl, J.R.,Mehdi, S.,Metz, W.A.,Peet, N.P.,Pelton, J.T.,Schreuder, H.A.,Sunder, S.,Tardif, C.
Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones.
J.Med.Chem., 41:2461-2480, 1998
Cited by
PubMed: 9651152
DOI: 10.1021/jm970812e
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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