1AU3

CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PYRROLIDINONE INHIBITOR

Summary for 1AU3

Entry DOI	10.2210/pdb1au3/pdb
Descriptor	CATHEPSIN K, 1-[N[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL-4-[[N/N-[(PHENYLMETHOXY)CARBONYL]-/NL-LEUCYL]AMINO]-3-PYRROLIDINONE/N (3 entities in total)
Functional Keywords	hydrolase, sulfhydryl proteinase
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P43235
Total number of polymer chains	1
Total formula weight	24118.18
Authors	Zhao, B.,Smith, W.W.,Janson, C.A.,Abdel-Meguid, S.S. (deposition date: 1997-09-10, release date: 1998-10-14, Last modification date: 2023-08-02)
Primary citation	Marquis, R.W.,Yamashita, D.S.,Ru, Y.,LoCastro, S.M.,Oh, H.J.,Erhard, K.F.,DesJarlais, R.L.,Head, M.S.,Smith, W.W.,Zhao, B.,Janson, C.A.,Abdel-Meguid, S.S.,Tomaszek, T.A.,Levy, M.A.,Veber, D.F. Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K. J.Med.Chem., 41:3563-3567, 1998 Cited by PubMed: 9733481 DOI: 10.1021/jm980295f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation