1AU0

CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT SYMMETRIC DIACYLAMINOMETHYL KETONE INHIBITOR

Summary for 1AU0

• Entry DOI: 10.2210/pdb1au0/pdb
• Descriptor: CATHEPSIN K, 1,3-BIS[[N-[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL]AMINO]-2-PROPANONE (3 entities in total)
• Functional Keywords: hydrolase, sulfhydryl proteinase
• Biological source: Homo sapiens (human)
• Cellular location: Lysosome: P43235
• Total number of polymer chains: 1
• Total formula weight: 24106.17

Authors

Zhao, B.,Smith, W.W.,Janson, C.A.,Abdel-Meguid, S.S. (deposition date: 1997-09-09, release date: 1998-10-14, Last modification date: 2023-08-02)

• Primary citation: Yamashita, D.S.,Smith, W.W.,Zhao, B.,Janson, C.A.,Tomaszek, T.A.,Bossard, M.J.,Levy, M.A.,Oh, H.-J.,Carr, T.J.,Thompson, S.K.,Ijames, C.F.,Carr, S.A.,Mcqueney, M.,D'Alessio, K.J.,Amegadzie, B.Y.,Hanning, C.R.,Abdel-Meguid, S.,Desjarlais, R.L.,Gleason, J.G.,Veber, D.F.; Structure and Design of Potent and Selective Cathepsin K Inhibitors; J.Am.Chem.Soc., 119:11351-11352, 1997

Experimental method

X-RAY DIFFRACTION (2.6 Å)