1AHW

A COMPLEX OF EXTRACELLULAR DOMAIN OF TISSUE FACTOR WITH AN INHIBITORY FAB (5G9)

1AHW の概要

• エントリーDOI: 10.2210/pdb1ahw/pdb
• 分子名称: IMMUNOGLOBULIN FAB 5G9 (LIGHT CHAIN), IMMUNOGLOBULIN FAB 5G9 (HEAVY CHAIN), TISSUE FACTOR (3 entities in total)
• 機能のキーワード: blood coagulation, tissue factor, fab, complex, antibody, complex (immunoglobulin-tissue factor), complex (immunoglobulin-tissue factor) complex, complex (immunoglobulin/tissue factor)
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P13726
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 143625.03

構造登録者

Huang, M.,Syed, R.,Stura, E.A.,Stone, M.J.,Stefanko, R.S.,Ruf, W.,Edgington, T.S.,Wilson, I.A. (登録日: 1997-04-10, 公開日: 1998-02-25, 最終更新日: 2023-08-02)

• 主引用文献: Huang, M.,Syed, R.,Stura, E.A.,Stone, M.J.,Stefanko, R.S.,Ruf, W.,Edgington, T.S.,Wilson, I.A.; The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.5G9 complex.; J.Mol.Biol., 275:873-894, 1998; PubMed: 9480775; DOI: 10.1006/jmbi.1997.1512

実験手法

X-RAY DIFFRACTION (3 Å)