1AD8

COMPLEX OF THROMBIN WITH AND INHIBITOR CONTAINING A NOVEL P1 MOIETY

1AD8 の概要

• エントリーDOI: 10.2210/pdb1ad8/pdb
• 分子名称: THROMBIN (SMALL SUBUNIT), THROMBIN (LARGE SUBUNIT), HIRUDIN (53-65) PEPTIDE, ... (6 entities in total)
• 機能のキーワード: complex (serine protease-inhibitor), hydrolase, serine protease, coagulant, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Hirudo medicinalis (medicinal leech); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P01050
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35827.69

構造登録者

Schreuder, H.,Tardif, C.,Malikayil, J.A. (登録日: 1997-02-24, 公開日: 1997-11-12, 最終更新日: 2024-04-03)

• 主引用文献: Malikayil, J.A.,Burkhart, J.P.,Schreuder, H.A.,Broersma Jr., R.J.,Tardif, C.,Kutcher 3rd., L.W.,Mehdi, S.,Schatzman, G.L.,Neises, B.,Peet, N.P.; Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.; Biochemistry, 36:1034-1040, 1997; PubMed: 9033393; DOI: 10.1021/bi9622231

実験手法

X-RAY DIFFRACTION (2 Å)