1A94

STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES

Summary for 1A94

Entry DOI	10.2210/pdb1a94/pdb
Related PRD ID	PRD_000349
Descriptor	PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide (3 entities in total)
Functional Keywords	human immunodeficiency virus protease, rous sarcoma virus protease, protein-mediated interaction, viral maturation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
Total number of polymer chains	4
Total formula weight	44628.55
Authors	Wu, J.,Adomat, J.M.,Ridky, T.W.,Louis, J.M.,Leis, J.,Harrison, R.W.,Weber, I.T. (deposition date: 1998-04-16, release date: 1999-01-13, Last modification date: 2024-02-07)
Primary citation	Wu, J.,Adomat, J.M.,Ridky, T.W.,Louis, J.M.,Leis, J.,Harrison, R.W.,Weber, I.T. Structural basis for specificity of retroviral proteases. Biochemistry, 37:4518-4526, 1998 Cited by PubMed: 9521772 DOI: 10.1021/bi972183g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation