1A8K

CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES

Summary for 1A8K

Entry DOI	10.2210/pdb1a8k/pdb
Related PRD ID	PRD_000349
Descriptor	HIV PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide (3 entities in total)
Functional Keywords	human immunodeficiency virus protease, proton-mediated interaction, viral maturation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains	4
Total formula weight	44885.34
Authors	Weber, I.T.,Wu, J.,Adomat, J.,Harrison, R.W.,Kimmel, A.R.,Wondrak, E.M.,Louis, J.M. (deposition date: 1998-03-27, release date: 1999-01-13, Last modification date: 2023-08-02)
Primary citation	Weber, I.T.,Wu, J.,Adomat, J.,Harrison, R.W.,Kimmel, A.R.,Wondrak, E.M.,Louis, J.M. Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates. Eur.J.Biochem., 249:523-530, 1997 Cited by PubMed: 9370363 DOI: 10.1111/j.1432-1033.1997.00523.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation