1A5H

CATALYTIC DOMAIN OF HUMAN TWO-CHAIN TISSUE PLASMINOGEN ACTIVATOR COMPLEX OF A BIS-BENZAMIDINE

Summary for 1A5H

Entry DOI	10.2210/pdb1a5h/pdb
Descriptor	TISSUE PLASMINOGEN ACTIVATOR, 2,7-BIS-(4-AMIDINOBENZYLIDENE)-CYCLOHEPTAN-1-ONE, ... (4 entities in total)
Functional Keywords	trypsin like serine protease, fibrinolytic enzyme, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	58750.69
Authors	Renatus, M.,Bode, W.,Stubbs, M.T. (deposition date: 1998-02-17, release date: 1999-04-20, Last modification date: 2023-08-02)
Primary citation	Renatus, M.,Bode, W.,Huber, R.,Sturzebecher, J.,Prasa, D.,Fischer, S.,Kohnert, U.,Stubbs, M.T. Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors. J.Biol.Chem., 272:21713-21719, 1997 Cited by PubMed: 9268299 DOI: 10.1074/jbc.272.35.21713 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation