1A46

THROMBIN COMPLEXED WITH HIRUGEN AND A BETA-STRAND MIMETIC INHIBITOR

Summary for 1A46

• Entry DOI: 10.2210/pdb1a46/pdb
• Related PRD ID: PRD_000617
• Descriptor: ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ... (6 entities in total)
• Functional Keywords: complex (serine protease-inhibitor), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P09945; Secreted: P00734
• Total number of polymer chains: 3
• Total formula weight: 35985.97

Authors

St Charles, R.,Matthews, J.H.,Zhang, E.,Tulinsky, A.,Kahn, M. (deposition date: 1998-02-11, release date: 1998-05-27, Last modification date: 2023-08-02)

• Primary citation: St Charles, R.,Matthews, J.H.,Zhang, E.,Tulinsky, A.; Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin.; J.Med.Chem., 42:1376-1383, 1999; PubMed: 10212123; DOI: 10.1021/jm980052n

Experimental method

X-RAY DIFFRACTION (2.12 Å)