1A3E

COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG2

1A3E の概要

• エントリーDOI: 10.2210/pdb1a3e/pdb
• 分子名称: ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), Hirudin, ... (5 entities in total)
• 機能のキーワード: complex (serine protease-inhibitor), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P28504
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 36530.92

構造登録者

Skordalakes, E.,Elgendy, S.,Goodwin, C.A.,Green, D.,Scullly, M.F.,Kakkar, V.V.,Freyssinet, J.M.,Dodson, G.,Deadman, J. (登録日: 1998-01-21, 公開日: 1998-06-03, 最終更新日: 2023-08-02)

• 主引用文献: Skordalakes, E.,Elgendy, S.,Goodwin, C.A.,Green, D.,Scully, M.F.,Kakkar, V.V.,Freyssinet, J.M.,Dodson, G.,Deadman, J.J.; Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.; Biochemistry, 37:14420-14427, 1998; PubMed: 9772168; DOI: 10.1021/bi980225a

実験手法

X-RAY DIFFRACTION (1.85 Å)