1A22

HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR

1A22 の概要

• エントリーDOI: 10.2210/pdb1a22/pdb
• 分子名称: GROWTH HORMONE, GROWTH HORMONE RECEPTOR (3 entities in total)
• 機能のキーワード: complex (hormone-receptor), pituitary, hormone, complex (hormone-receptor) complex, complex (hormone/receptor)
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P01241; Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Growth hormone-binding protein: Secreted: P10912
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49661.91

構造登録者

De Vos, A.M.,Ultsch, M. (登録日: 1998-01-15, 公開日: 1998-04-29, 最終更新日: 2023-08-02)

• 主引用文献: Clackson, T.,Ultsch, M.H.,Wells, J.A.,de Vos, A.M.; Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.; J.Mol.Biol., 277:1111-1128, 1998; PubMed: 9571026; DOI: 10.1006/jmbi.1998.1669

実験手法

X-RAY DIFFRACTION (2.6 Å)