1TJI

Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a gp41 17mer epitope

Summary for 1TJI

• Entry DOI: 10.2210/pdb1tji/pdb
• Related: 1TJG 1TJH 2F5B
• Descriptor: anti-HIV-1 antibody 2F5 Light Chain, anti-HIV-1 antibody 2F5 Heavy Chain, Envelope Glycoprotein GP41, ... (6 entities in total)
• Functional Keywords: 2f5, antibody, gp41, hiv-1, neutralizing, membrane-proximal, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Transmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein: P04580
• Total number of polymer chains: 3
• Total formula weight: 51327.79

Authors

Ofek, G.,Tang, M.,Sambor, A.,Katinger, H.,Mascola, J.R.,Wyatt, R.,Kwong, P.D. (deposition date: 2004-06-04, release date: 2004-10-05, Last modification date: 2023-08-23)

• Primary citation: Ofek, G.,Tang, M.,Sambor, A.,Katinger, H.,Mascola, J.R.,Wyatt, R.,Kwong, P.D.; Structure and mechanistic analysis of the Anti-Human Immunodeficiency Virus type 1 antibody 2F5 in complex with its gp41 epitope; J.Virol., 78:10724-10737, 2004; PubMed: 15367639; DOI: 10.1128/JVI.78.19.10724-10737.2004

Experimental method

X-RAY DIFFRACTION (2.2 Å)