4K98
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cyclic GMP-AMP synthase | polymer | 362 | 42512.1 | 1 | UniProt (Q8C6L5) Pfam (PF03281) Pfam (PF20266) In PDB | Mus musculus (mouse) | cGAMP synthase, cGAS, m-cGAS, Mab-21 domain-containing protein 1 |
| 2 | D | DNA-F | polymer | 17 | 5253.5 | 1 | |||
| 3 | E | DNA-R | polymer | 17 | 5159.3 | 1 | |||
| 4 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | A | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 7 | A | GUANOSINE-5'-MONOPHOSPHATE | non-polymer | 363.2 | 1 | Chemie (G) | |||
| 8 | water | water | 18.0 | 361 | Chemie (HOH) |
Sequence modifications
A: 147 - 507 (UniProt: Q8C6L5)
| PDB | External Database | Details |
|---|---|---|
| Ser 146 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 52924.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1000.4 | |
| All* | Total formula weight | 53925.3 |
