4PFD
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6L6K
| Crystal structure of dimeric RXRalpha-LBD complexed with partial agonist CBt-PMN and SRC1 | Descriptor: | 1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)benzotriazole-5-carboxylic acid, CALCIUM ION, Nuclear receptor coactivator 1, ... | Authors: | Shimizu, K, Numoto, N, Nakano, S, Makishima, M, Kakuta, H, Ito, N. | Deposit date: | 2019-10-29 | Release date: | 2020-11-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of dimeric RXRalpha-LBD complexed with partial agonist CBt-PMN and SRC1 To Be Published
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5ZQU
| Crystal structure of tetrameric RXRalpha-LBD complexed with partial agonist CBt-PMN | Descriptor: | 1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)benzotriazole-5-carboxylic acid, BROMIDE ION, Retinoic acid receptor RXR-alpha | Authors: | Miyashita, Y, Numoto, N, Arulmozhiraja, S, Nakano, S, Matsuo, N, Shimizu, K, Kakuta, H, Ito, S, Ikura, T, Ito, N, Tokiwa, H. | Deposit date: | 2018-04-20 | Release date: | 2019-02-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.60038781 Å) | Cite: | Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor alpha (RXR alpha ). FEBS Lett., 593, 2019
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1PZO
| TEM-1 Beta-Lactamase in Complex with a Novel, Core-Disrupting, Allosteric Inhibitor | Descriptor: | Beta-lactamase TEM, N,N-BIS(4-CHLOROBENZYL)-1H-1,2,3,4-TETRAAZOL-5-AMINE | Authors: | Horn, J.R, Shoichet, B.K. | Deposit date: | 2003-07-14 | Release date: | 2004-03-09 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Allosteric inhibition through core disruption. J.Mol.Biol., 336, 2004
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7OUI
| Structure of C2S2M2-type Photosystem supercomplex from Arabidopsis thaliana (digitonin-extracted) | Descriptor: | (1R,3R)-6-{(3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1S,4R,6R)-4-HYDROXY-2,2,6-TRIMETHYL-7-OXABICYCLO[4.1.0]HEPT-1-YL]-3,7,12,16-TETRAMETHYLOCTADECA-1,3,5,7,9,11,13,15,17-NONAENYLIDENE}-1,5,5-TRIMETHYLCYCLOHEXANE-1,3-DIOL, (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, ... | Authors: | Graca, A.T, Hall, M, Persson, K, Schroder, W.P. | Deposit date: | 2021-06-11 | Release date: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | High-resolution model of Arabidopsis Photosystem II reveals the structural consequences of digitonin-extraction. Sci Rep, 11, 2021
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6H12
| Crystal structure of TcACHE complexed to 1-(6-Oxo-1,2,3,4,6,10b-hexahydropyrido[2,1-a]isoindol-10-yl)-3-(4-(((1-(2-((1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)methyl)pyridin-2-yl)urea | Descriptor: | 1,2-ETHANEDIOL, 1-[4-[[1-[2-(1,2,3,4,4~{a},9~{a}-hexahydroacridin-9-ylamino)ethyl]-1,2,3-triazol-4-yl]methoxymethyl]pyridin-2-yl]-3-[(10~{b}~{R})-6-oxidanylidene-2,3,4,10~{b}-tetrahydro-1~{H}-pyrido[2,1-a]isoindol-10-yl]urea, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | Authors: | Coquelle, N, Colletier, J.P. | Deposit date: | 2018-07-10 | Release date: | 2019-05-15 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3. Eur.J.Med.Chem., 168, 2019
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3W2Q
| EGFR kinase domain T790M/L858R mutant with HKI-272 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Epidermal growth factor receptor, N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Authors: | Sogabe, S, Kawakita, Y, Igaki, S. | Deposit date: | 2012-12-03 | Release date: | 2013-01-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors. Acs Med.Chem.Lett., 4, 2013
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1CGL
| Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor | Descriptor: | CALCIUM ION, FIBROBLAST COLLAGENASE, N-[(1S)-3-{[(benzyloxy)carbonyl]amino}-1-carboxypropyl]-L-leucyl-N-(2-morpholin-4-ylethyl)-L-phenylalaninamide, ... | Authors: | Lovejoy, B, Cleasby, A, Hassell, A.M, Longley, K, Luther, M.A, Weigl, D, Mcgeehan, G, Mcelroy, A.B, Drewry, D, Lambert, M.H, Jordan, S.R. | Deposit date: | 1993-11-17 | Release date: | 1995-02-27 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor. Science, 263, 1994
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4AEA
| Dimeric alpha-cobratoxin X-ray structure: Localization of intermolecular disulfides and possible mode of binding to nicotinic acetylcholine receptors | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCINE, LONG NEUROTOXIN 1 | Authors: | Rucktooa, P, Osipov, A.V, Kasheverov, I.E, Filkin, S.Y, Starkov, V.G, Andreeva, T.V, Bertrand, D, Utkin, Y.N, Tsetlin, V.I, Sixma, T.K. | Deposit date: | 2012-01-09 | Release date: | 2012-01-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Dimeric Alpha-Cobratoxin X-Ray Structure: Localization of Intermolecular Disulfides and Possible Mode of Binding to Nicotinic Acetylcholine Receptors. J.Biol.Chem., 287, 2012
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7ULG
| recombinant alpha cobra toxin | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, Alpha-cobratoxin | Authors: | Xu, J, Lei, X, Chen, L. | Deposit date: | 2022-04-04 | Release date: | 2023-05-03 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Structure of recombinant alpha cobra toxin at 1.57 Angstroms To Be Published
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1BSF
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2ECP
| THE CRYSTAL STRUCTURE OF THE E. COLI MALTODEXTRIN PHOSPHORYLASE COMPLEX | Descriptor: | 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, GLYCEROL, MALTODEXTRIN PHOSPHORYLASE, ... | Authors: | O'Reilly, M, Watson, K.A, Johnson, L.N. | Deposit date: | 1998-10-27 | Release date: | 1999-06-15 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | The crystal structure of the Escherichia coli maltodextrin phosphorylase-acarbose complex. Biochemistry, 38, 1999
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7PC0
| GABA-A receptor bound by a-Cobratoxin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-cobratoxin, ... | Authors: | Kasaragod, V.B, Miller, P.S. | Deposit date: | 2021-08-03 | Release date: | 2022-02-09 | Last modified: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Mechanisms of inhibition and activation of extrasynaptic alpha beta GABA A receptors. Nature, 602, 2022
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1VB0
| Atomic resolution structure of atratoxin-b, one short-chain neurotoxin from Naja atra | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cobrotoxin b, SULFATE ION | Authors: | Lou, X, Liu, Q, Teng, M, Niu, L, Huang, Q, Hao, Q. | Deposit date: | 2004-02-20 | Release date: | 2004-12-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (0.92 Å) | Cite: | The atomic resolution crystal structure of atratoxin determined by single wavelength anomalous diffraction phasing J.Biol.Chem., 279, 2004
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1V6P
| Crystal structure of Cobrotoxin | Descriptor: | CHLORIDE ION, COPPER (II) ION, Cobrotoxin, ... | Authors: | Lou, X, Tu, X, Wang, J, Teng, M, Niu, L, Liu, Q, Huang, Q, Hao, Q. | Deposit date: | 2003-12-03 | Release date: | 2004-12-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (0.87 Å) | Cite: | The atomic resolution crystal structure of atratoxin determined by single wavelength anomalous diffraction phasing J.Biol.Chem., 279, 2004
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1MDT
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1NW7
| Structure of the beta class N6-adenine DNA methyltransferase RsrI bound to S-ADENOSYL-L-HOMOCYSTEINE | Descriptor: | CHLORIDE ION, MODIFICATION METHYLASE RSRI, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Thomas, C.B, Scavetta, R.D, Gumport, R.I, Churchill, M.E.A. | Deposit date: | 2003-02-05 | Release date: | 2003-07-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding J.Biol.Chem., 278, 2003
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1F0L
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1FIE
| RECOMBINANT HUMAN COAGULATION FACTOR XIII | Descriptor: | COAGULATION FACTOR XIII | Authors: | Yee, V.C, Teller, D.C. | Deposit date: | 1996-08-24 | Release date: | 1997-02-12 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural evidence that the activation peptide is not released upon thrombin cleavage of factor XIII. Thromb.Res., 78, 1995
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1GGY
| HUMAN FACTOR XIII WITH YTTERBIUM BOUND IN THE ION SITE | Descriptor: | PROTEIN (COAGULATION FACTOR XIII), YTTERBIUM (III) ION | Authors: | Fox, B.A, Yee, V.C, Pederson, L.C, Trong, I.L, Bishop, P.D, Stenkamp, R.E, Teller, D.C. | Deposit date: | 1998-07-23 | Release date: | 1999-02-16 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Identification of the calcium binding site and a novel ytterbium site in blood coagulation factor XIII by x-ray crystallography. J.Biol.Chem., 274, 1999
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1GGU
| HUMAN FACTOR XIII WITH CALCIUM BOUND IN THE ION SITE | Descriptor: | CALCIUM ION, PROTEIN (COAGULATION FACTOR XIII) | Authors: | Fox, B.A, Yee, V.C, Pederson, L.C, Trong, I.L, Bishop, P.D, Stenkamp, R.E, Teller, D.C. | Deposit date: | 1998-07-22 | Release date: | 1999-09-16 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Identification of the calcium binding site and a novel ytterbium site in blood coagulation factor XIII by x-ray crystallography. J.Biol.Chem., 274, 1999
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1GGT
| THREE-DIMENSIONAL STRUCTURE OF A TRANSGLUTAMINASE: HUMAN BLOOD COAGULATION FACTOR XIII | Descriptor: | COAGULATION FACTOR XIII | Authors: | Yee, V.C, Pedersen, L.C, Trong, I.L, Bishop, P.D, Stenkamp, R.E, Teller, D.C. | Deposit date: | 1994-01-25 | Release date: | 1995-07-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Three-dimensional structure of a transglutaminase: human blood coagulation factor XIII. Proc.Natl.Acad.Sci.USA, 91, 1994
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1NW5
| Structure of the beta class N6-adenine DNA methyltransferase RsrI bound to S-ADENOSYLMETHIONINE | Descriptor: | CHLORIDE ION, MODIFICATION METHYLASE RSRI, S-ADENOSYLMETHIONINE | Authors: | Thomas, C.B, Scavetta, R.D, Gumport, R.I, Churchill, M.E.A. | Deposit date: | 2003-02-05 | Release date: | 2003-07-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding J.Biol.Chem., 278, 2003
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1NW6
| Structure of the beta class N6-adenine DNA methyltransferase RsrI bound to sinefungin | Descriptor: | CHLORIDE ION, MODIFICATION METHYLASE RSRI, SINEFUNGIN | Authors: | Thomas, C.B, Scavetta, R.D, Gumport, R.I, Churchill, M.E.A. | Deposit date: | 2003-02-05 | Release date: | 2003-07-29 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding J.Biol.Chem., 278, 2003
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1NW8
| Structure of L72P mutant beta class N6-adenine DNA methyltransferase RsrI | Descriptor: | CHLORIDE ION, MODIFICATION METHYLASE RSRI | Authors: | Thomas, C.B, Scavetta, R.D, Gumport, R.I, Churchill, M.E.A. | Deposit date: | 2003-02-05 | Release date: | 2003-07-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding J.Biol.Chem., 278, 2003
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