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8E7A
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Crystal structure of the p53 (Y107H) core domain orthorhombic P form
Descriptor: Cellular tumor antigen p53, ZINC ION
Authors:Lovell, S, Liu, L, Battaile, K.P, Miller, S, Karanicolas, J.
Deposit date:2022-08-23
Release date:2023-05-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.
Cancer Discov, 13, 2023
8E7B
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BU of 8e7b by Molmil
Crystal structure of the p53 (Y107H) core domain monoclinic P form
Descriptor: Cellular tumor antigen p53, ZINC ION
Authors:Lovell, S, Liu, L, Battaile, K.P, Miller, S, Karanicolas, J.
Deposit date:2022-08-23
Release date:2023-05-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.
Cancer Discov, 13, 2023
7VOV
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BU of 7vov by Molmil
The crystal structure of human forkhead box protein in complex with DNA 2
Descriptor: DNA (5'-D(P*AP*AP*AP*TP*AP*TP*TP*TP*AP*TP*TP*AP*TP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*AP*TP*AP*AP*TP*AP*AP*AP*TP*AP*TP*T)-3'), Forkhead box protein L2
Authors:Choi, Y, Yoon, H.J, Lee, H.H.
Deposit date:2021-10-15
Release date:2022-08-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations.
Nucleic Acids Res., 50, 2022
7VOU
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The crystal structure of human forkhead box protein in complex with DNA 1
Descriptor: DNA (5'-D(*AP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*T)-3'), Forkhead box protein L2
Authors:Choi, Y, Yoon, H.J, Lee, H.H.
Deposit date:2021-10-14
Release date:2022-08-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations.
Nucleic Acids Res., 50, 2022
7VOX
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The crystal structure of human forkhead box protein A in complex with DNA 2
Descriptor: DNA (5'-D(P*AP*AP*AP*TP*AP*TP*TP*TP*AP*TP*TP*AP*TP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*AP*TP*AP*AP*TP*AP*AP*AP*TP*AP*TP*TP*T)-3'), Hepatocyte nuclear factor 3-alpha, ...
Authors:Choi, Y, Yoon, H.J, Lee, H.H.
Deposit date:2021-10-15
Release date:2022-08-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations.
Nucleic Acids Res., 50, 2022
3DCY
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BU of 3dcy by Molmil
Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.
Descriptor: PHOSPHATE ION, REGULATOR PROTEIN
Authors:McCoy, J.G, Bingman, C.A, Wesenberg, G.E, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2008-06-04
Release date:2008-07-15
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.748 Å)
Cite:Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.
To be Published
8HKW
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BU of 8hkw by Molmil
Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal
Descriptor: Importin subunit alpha-3, Peptide from TP53-binding protein 1
Authors:Matsuura, Y.
Deposit date:2022-11-28
Release date:2022-12-21
Last modified:2023-03-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic data of an importin-alpha 3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal.
Data Brief, 47, 2023
3E9C
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BU of 3e9c by Molmil
Structure of a tryptic core fragment of TIGAR from Danio rerio
Descriptor: POTASSIUM ION, Zgc:56074
Authors:Li, H, Jogl, G.
Deposit date:2008-08-21
Release date:2008-12-16
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:TIGAR (TP53 induced glycolysis and apoptosis regulator) is a fructose-2,6- and fructose-1,6-bisphosphatase
To be Published
3E9D
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BU of 3e9d by Molmil
Structure of full-length TIGAR from Danio rerio
Descriptor: PHOSPHATE ION, POTASSIUM ION, Zgc:56074
Authors:Li, H, Jogl, G.
Deposit date:2008-08-21
Release date:2008-12-16
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:TIGAR (TP53 induced glycolysis and apoptosis regulator) is a fructose-2,6- and fructose-1,6-bisphosphatase
To be Published
3E9E
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BU of 3e9e by Molmil
Structure of full-length H11A mutant form of TIGAR from Danio rerio
Descriptor: PHOSPHATE ION, Zgc:56074
Authors:Li, H, Jogl, G.
Deposit date:2008-08-21
Release date:2008-12-16
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:TIGAR (TP53 induced glycolysis and apoptosis regulator) is a fructose-2,6- and fructose-1,6-bisphosphatase
To be Published
6IU7
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BU of 6iu7 by Molmil
Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (wild-type)
Descriptor: Importin subunit alpha-1, Peptide from TP53-binding protein 1
Authors:Matsuura, Y.
Deposit date:2018-11-27
Release date:2019-01-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and biochemical characterization of the recognition of the 53BP1 nuclear localization signal by importin-alpha.
Biochem. Biophys. Res. Commun., 510, 2019
6IUA
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BU of 6iua by Molmil
Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (S1678D)
Descriptor: Importin subunit alpha-1, Peptide from TP53-binding protein 1
Authors:Matsuura, Y.
Deposit date:2018-11-27
Release date:2019-01-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and biochemical characterization of the recognition of the 53BP1 nuclear localization signal by importin-alpha.
Biochem. Biophys. Res. Commun., 510, 2019
6W51
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BU of 6w51 by Molmil
Structure of the antibody fragment H2 in complex with HLA-A*02:01/p53R175H
Descriptor: Beta-2-microglobulin, Cellular tumor antigen p53 peptide, Immunoglobulin heavy chain H2, ...
Authors:Wright, K.M, Gabelli, S.B.
Deposit date:2020-03-12
Release date:2021-03-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.53 Å)
Cite:Targeting a neoantigen derived from a common TP53 mutation.
Science, 371, 2021
5ZCJ
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BU of 5zcj by Molmil
Crystal structure of complex
Descriptor: TP53-binding protein 1, Tudor-interacting repair regulator protein
Authors:Wang, J, Yuan, Z, Cui, Y, Xie, R, Wang, M, Ma, Y, Yu, X, Liu, X.
Deposit date:2018-02-17
Release date:2018-06-27
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:Crystal structure of complex
To Be Published
5Z78
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BU of 5z78 by Molmil
Structure of TIRR/53BP1 complex
Descriptor: TP53-binding protein 1, Tudor-interacting repair regulator protein
Authors:Dai, Y.X, Shan, S.
Deposit date:2018-01-27
Release date:2018-06-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.762 Å)
Cite:Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR
Nat Commun, 9, 2018
6CO1
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BU of 6co1 by Molmil
Structure of human TIRR in complex with 53BP1 Tudor domains
Descriptor: TP53-binding protein 1, Tudor-interacting repair regulator protein
Authors:Cui, G, Botuyan, M.V, Mer, G.
Deposit date:2018-03-10
Release date:2018-06-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.179 Å)
Cite:Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein.
Nat. Struct. Mol. Biol., 25, 2018
6VIP
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BU of 6vip by Molmil
TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-6008
Descriptor: TP53-binding protein 1, UNKNOWN ATOM OR ION, {4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]phenyl}(4-ethylpiperazin-1-yl)methanone
Authors:The, J, Hong, Z, Dong, A, Headey, S, Gunzburg, M, Doak, B, James, L.I, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2020-01-13
Release date:2020-02-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-6008
to be published
8U4U
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BU of 8u4u by Molmil
Crystal structure of 53BP1 tandem Tudor domain homodimer engineered with two disulfide bridges
Descriptor: TP53-binding protein 1
Authors:Cui, G, Botuyan, M.V, Thompson, J.R, Mer, G.
Deposit date:2023-09-11
Release date:2023-09-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.79 Å)
Cite:An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
6MY0
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BU of 6my0 by Molmil
Structure of 53BP1 Tandem Tudor domains with E1549P and D1550N mutations
Descriptor: TP53-binding protein 1
Authors:Cui, G, Botuyan, M.V, Mer, G.
Deposit date:2018-10-31
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
7DHY
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BU of 7dhy by Molmil
Arsenic-bound p53 DNA-binding domain mutant G245S
Descriptor: ARSENIC, Cellular tumor antigen p53, GLYCEROL, ...
Authors:Chen, S, Lu, M.
Deposit date:2020-11-18
Release date:2021-03-03
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.
Cancer Cell, 39, 2021
7DHZ
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BU of 7dhz by Molmil
Arsenic-bound p53 DNA-binding domain mutant R249S
Descriptor: ARSENIC, Cellular tumor antigen p53, GLYCEROL, ...
Authors:Chen, S, Lu, M.
Deposit date:2020-11-18
Release date:2021-03-03
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.
Cancer Cell, 39, 2021
6I3V
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BU of 6i3v by Molmil
x-ray structure of the human mitochondrial PRELID1 in complex with TRIAP1
Descriptor: CHLORIDE ION, MYRISTIC ACID, PRELI domain-containing protein 1, ...
Authors:Berry, J.L, Miliara, X, Morgan, R.M.L, Matthews, S.J.
Deposit date:2018-11-07
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins.
Nat Commun, 10, 2019
8SWJ
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BU of 8swj by Molmil
Co-crystal structure of 53BP1 tandem Tudor domains in complex with UNC8531
Descriptor: (3S)-N-(4'-carbamoyl[1,1'-biphenyl]-3-yl)-1-[4-(4-methylpiperazin-1-yl)pyridine-2-carbonyl]piperidine-3-carboxamide, TP53-binding protein 1, UNKNOWN ATOM OR ION
Authors:Zeng, H, Dong, A, Shell, D.J, Foley, C, Pearce, K.H, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2023-05-18
Release date:2023-08-02
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Co-crystal structure of 53BP1 tandem Tudor domains in complex with UNC8531
To be published
4XZS
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BU of 4xzs by Molmil
Crystal Structure of TRIAP1-MBP fusion
Descriptor: Maltose-binding periplasmic protein,TP53-regulated inhibitor of apoptosis 1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Miliara, X, Garnett, J.A, Abid-Ali, F, Perez-Dorado, I, Matthews, S.J.
Deposit date:2015-02-04
Release date:2016-01-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes.
Embo Rep., 16, 2015
4XZV
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BU of 4xzv by Molmil
Crystal Structure of SLMO1-TRIAP1 Complex
Descriptor: Maltose-binding periplasmic protein,TP53-regulated inhibitor of apoptosis 1, Protein slowmo homolog 1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Miliara, X, Garnett, J.A, Matthews, S.J.
Deposit date:2015-02-05
Release date:2016-01-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.58 Å)
Cite:Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes.
Embo Rep., 16, 2015

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PDB entries from 2024-03-13

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