8E7A
| Crystal structure of the p53 (Y107H) core domain orthorhombic P form | Descriptor: | Cellular tumor antigen p53, ZINC ION | Authors: | Lovell, S, Liu, L, Battaile, K.P, Miller, S, Karanicolas, J. | Deposit date: | 2022-08-23 | Release date: | 2023-05-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression. Cancer Discov, 13, 2023
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8E7B
| Crystal structure of the p53 (Y107H) core domain monoclinic P form | Descriptor: | Cellular tumor antigen p53, ZINC ION | Authors: | Lovell, S, Liu, L, Battaile, K.P, Miller, S, Karanicolas, J. | Deposit date: | 2022-08-23 | Release date: | 2023-05-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression. Cancer Discov, 13, 2023
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7VOV
| The crystal structure of human forkhead box protein in complex with DNA 2 | Descriptor: | DNA (5'-D(P*AP*AP*AP*TP*AP*TP*TP*TP*AP*TP*TP*AP*TP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*AP*TP*AP*AP*TP*AP*AP*AP*TP*AP*TP*T)-3'), Forkhead box protein L2 | Authors: | Choi, Y, Yoon, H.J, Lee, H.H. | Deposit date: | 2021-10-15 | Release date: | 2022-08-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations. Nucleic Acids Res., 50, 2022
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7VOU
| The crystal structure of human forkhead box protein in complex with DNA 1 | Descriptor: | DNA (5'-D(*AP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*T)-3'), Forkhead box protein L2 | Authors: | Choi, Y, Yoon, H.J, Lee, H.H. | Deposit date: | 2021-10-14 | Release date: | 2022-08-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations. Nucleic Acids Res., 50, 2022
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7VOX
| The crystal structure of human forkhead box protein A in complex with DNA 2 | Descriptor: | DNA (5'-D(P*AP*AP*AP*TP*AP*TP*TP*TP*AP*TP*TP*AP*TP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*AP*TP*AP*AP*TP*AP*AP*AP*TP*AP*TP*TP*T)-3'), Hepatocyte nuclear factor 3-alpha, ... | Authors: | Choi, Y, Yoon, H.J, Lee, H.H. | Deposit date: | 2021-10-15 | Release date: | 2022-08-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations. Nucleic Acids Res., 50, 2022
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3DCY
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8HKW
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3E9C
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3E9D
| Structure of full-length TIGAR from Danio rerio | Descriptor: | PHOSPHATE ION, POTASSIUM ION, Zgc:56074 | Authors: | Li, H, Jogl, G. | Deposit date: | 2008-08-21 | Release date: | 2008-12-16 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | TIGAR (TP53 induced glycolysis and apoptosis regulator) is a fructose-2,6- and fructose-1,6-bisphosphatase To be Published
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3E9E
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6IU7
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6IUA
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6W51
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5ZCJ
| Crystal structure of complex | Descriptor: | TP53-binding protein 1, Tudor-interacting repair regulator protein | Authors: | Wang, J, Yuan, Z, Cui, Y, Xie, R, Wang, M, Ma, Y, Yu, X, Liu, X. | Deposit date: | 2018-02-17 | Release date: | 2018-06-27 | Method: | X-RAY DIFFRACTION (2.004 Å) | Cite: | Crystal structure of complex To Be Published
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5Z78
| Structure of TIRR/53BP1 complex | Descriptor: | TP53-binding protein 1, Tudor-interacting repair regulator protein | Authors: | Dai, Y.X, Shan, S. | Deposit date: | 2018-01-27 | Release date: | 2018-06-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.762 Å) | Cite: | Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR Nat Commun, 9, 2018
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6CO1
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6VIP
| TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-6008 | Descriptor: | TP53-binding protein 1, UNKNOWN ATOM OR ION, {4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]phenyl}(4-ethylpiperazin-1-yl)methanone | Authors: | The, J, Hong, Z, Dong, A, Headey, S, Gunzburg, M, Doak, B, James, L.I, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | Deposit date: | 2020-01-13 | Release date: | 2020-02-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-6008 to be published
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8U4U
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6MY0
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7DHY
| Arsenic-bound p53 DNA-binding domain mutant G245S | Descriptor: | ARSENIC, Cellular tumor antigen p53, GLYCEROL, ... | Authors: | Chen, S, Lu, M. | Deposit date: | 2020-11-18 | Release date: | 2021-03-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site. Cancer Cell, 39, 2021
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7DHZ
| Arsenic-bound p53 DNA-binding domain mutant R249S | Descriptor: | ARSENIC, Cellular tumor antigen p53, GLYCEROL, ... | Authors: | Chen, S, Lu, M. | Deposit date: | 2020-11-18 | Release date: | 2021-03-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site. Cancer Cell, 39, 2021
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6I3V
| x-ray structure of the human mitochondrial PRELID1 in complex with TRIAP1 | Descriptor: | CHLORIDE ION, MYRISTIC ACID, PRELI domain-containing protein 1, ... | Authors: | Berry, J.L, Miliara, X, Morgan, R.M.L, Matthews, S.J. | Deposit date: | 2018-11-07 | Release date: | 2019-03-20 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins. Nat Commun, 10, 2019
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8SWJ
| Co-crystal structure of 53BP1 tandem Tudor domains in complex with UNC8531 | Descriptor: | (3S)-N-(4'-carbamoyl[1,1'-biphenyl]-3-yl)-1-[4-(4-methylpiperazin-1-yl)pyridine-2-carbonyl]piperidine-3-carboxamide, TP53-binding protein 1, UNKNOWN ATOM OR ION | Authors: | Zeng, H, Dong, A, Shell, D.J, Foley, C, Pearce, K.H, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | Deposit date: | 2023-05-18 | Release date: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Co-crystal structure of 53BP1 tandem Tudor domains in complex with UNC8531 To be published
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4XZS
| Crystal Structure of TRIAP1-MBP fusion | Descriptor: | Maltose-binding periplasmic protein,TP53-regulated inhibitor of apoptosis 1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Miliara, X, Garnett, J.A, Abid-Ali, F, Perez-Dorado, I, Matthews, S.J. | Deposit date: | 2015-02-04 | Release date: | 2016-01-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes. Embo Rep., 16, 2015
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4XZV
| Crystal Structure of SLMO1-TRIAP1 Complex | Descriptor: | Maltose-binding periplasmic protein,TP53-regulated inhibitor of apoptosis 1, Protein slowmo homolog 1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Miliara, X, Garnett, J.A, Matthews, S.J. | Deposit date: | 2015-02-05 | Release date: | 2016-01-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.58 Å) | Cite: | Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes. Embo Rep., 16, 2015
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