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8D3F
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BU of 8d3f by Molmil
Crystal structure of human STAT1 in complex with the repeat region from Toxoplasma protein TgIST
Descriptor: Signal transducer and activator of transcription 1-alpha/beta,Inhibitor of STAT1-dependent transcription TgIST
Authors:Huang, Z, Liu, H, Nix, J.C, Amarasinghe, G.K, Sibley, L.D.
Deposit date:2022-06-01
Release date:2022-07-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment.
Nat Commun, 13, 2022
7NUF
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BU of 7nuf by Molmil
Vaccinia virus protein 018 in complex with STAT1
Descriptor: ACETYL GROUP, SULFATE ION, Signal transducer and activator of transcription 1-alpha/beta, ...
Authors:Pantelejevs, T, Talbot-Cooper, C, Smith, G.L, Hyvonen, M.
Deposit date:2021-03-12
Release date:2021-07-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.0004015 Å)
Cite:Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling.
Cell Host Microbe, 30, 2022
1YVL
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BU of 1yvl by Molmil
Structure of Unphosphorylated STAT1
Descriptor: 5-residue peptide, GOLD ION, Signal transducer and activator of transcription 1-alpha/beta
Authors:Mao, X, Ren, Z, Parker, G.N, Sondermann, H, Pastorello, M.A, Wang, W, McMurray, J.S, Demeler, B, Darnell Jr, J.E, Chen, X.
Deposit date:2005-02-16
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural bases of unphosphorylated STAT1 association and receptor binding.
Mol.Cell, 17, 2005
2KA6
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BU of 2ka6 by Molmil
NMR structure of the CBP-TAZ2/STAT1-TAD complex
Descriptor: CREB-binding protein, Signal transducer and activator of transcription 1-alpha/beta, ZINC ION
Authors:Wojciak, J.M, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E.
Deposit date:2008-10-30
Release date:2009-04-07
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains.
Embo J., 28, 2009
3WWT
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BU of 3wwt by Molmil
Crystal Structure of the Y3:STAT1ND complex
Descriptor: C' protein, CALCIUM ION, Signal transducer and activator of transcription 1-alpha/beta
Authors:Oda, K, Sakaguchi, T, Matoba, Y.
Deposit date:2014-06-27
Release date:2015-07-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein.
J.Virol., 89, 2015
4U2X
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BU of 4u2x by Molmil
Ebola virus VP24 in complex with Karyopherin alpha 5 C-terminus
Descriptor: CHLORIDE ION, Importin subunit alpha-6, Membrane-associated protein VP24
Authors:Xu, W, Leung, D, Borek, D, Amarasinghe, G.
Deposit date:2014-07-18
Release date:2014-08-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.153 Å)
Cite:Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1.
Cell Host Microbe, 16, 2014
4D9O
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BU of 4d9o by Molmil
Structure of ebolavirus protein VP24 from Reston
Descriptor: Membrane-associated protein VP24
Authors:Zhang, A.P.P.
Deposit date:2012-01-11
Release date:2012-04-18
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold
Plos Pathog., 8, 2012
3VNE
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BU of 3vne by Molmil
Structure of the ebolavirus protein VP24 from Sudan
Descriptor: Membrane-associated protein VP24
Authors:Zhang, A.P.P.
Deposit date:2012-01-12
Release date:2012-04-18
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold
Plos Pathog., 8, 2012
3VNF
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BU of 3vnf by Molmil
Structure of the ebolavirus protein VP24 from Sudan
Descriptor: Membrane-associated protein VP24
Authors:Zhang, A.P.P.
Deposit date:2012-01-12
Release date:2012-04-18
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold
Plos Pathog., 8, 2012
2KA4
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BU of 2ka4 by Molmil
NMR structure of the CBP-TAZ1/STAT2-TAD complex
Descriptor: Crebbp protein, Signal transducer and activator of transcription 2, ZINC ION
Authors:Wojciak, J.M, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E.
Deposit date:2008-10-30
Release date:2009-04-21
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains
Embo J., 28, 2009
3CM3
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BU of 3cm3 by Molmil
High Resolution Crystal Structure of the Vaccinia Virus Dual-Specificity Phosphatase VH1
Descriptor: BETA-MERCAPTOETHANOL, Dual specificity protein phosphatase, PHOSPHATE ION
Authors:Koksal, A.C, Cingolani, G.
Deposit date:2008-03-20
Release date:2009-02-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Dimeric Quaternary Structure of the Prototypical Dual Specificity Phosphatase VH1.
J.Biol.Chem., 284, 2009
1BF5
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BU of 1bf5 by Molmil
TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX
Descriptor: DNA (5'-D(*AP*CP*AP*GP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*G P*C)-3'), DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*CP*T P*G)-3'), SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
Authors:Kuriyan, J, Zhao, Y, Chen, X, Vinkemeier, U, Jeruzalmi, D, Darnell Jr, J.E.
Deposit date:1998-05-27
Release date:1998-08-12
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA.
Cell(Cambridge,Mass.), 93, 1998
3CWG
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BU of 3cwg by Molmil
Unphosphorylated mouse STAT3 core fragment
Descriptor: Signal transducer and activator of transcription 3
Authors:Ren, Z, Mao, X, Mertens, C, Krishnaraj, R, Qin, J, Mandal, P.K, Romanowshi, M.J, McMurray, J.S.
Deposit date:2008-04-21
Release date:2008-07-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structure of unphosphorylated STAT3 core fragment.
Biochem.Biophys.Res.Commun., 374, 2008
6WEO
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BU of 6weo by Molmil
IL-22 Signaling Complex with IL-22R1 and IL-10Rbeta
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Saxton, R.A, Jude, K.M, Henneberg, L.T, Garcia, K.C.
Deposit date:2020-04-02
Release date:2021-04-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design.
Immunity, 54, 2021
5BNJ
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BU of 5bnj by Molmil
CDK8/CYCC IN COMPLEX WITH 8-{3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)-phenyl]-pyridin- 4-yl}-2,8-diaza-spiro[4.5]decan-1-one
Descriptor: 8-{3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyridin-4-yl}-2,8-diazaspiro[4.5]decan-1-one, Cyclin-C, Cyclin-dependent kinase 8, ...
Authors:Musil, D, Blagg, J, Wienke, D.
Deposit date:2015-05-26
Release date:2015-10-14
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.
Nat.Chem.Biol., 11, 2015
6VKF
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BU of 6vkf by Molmil
CCHFV GP38 (IbAr10200)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GP38
Authors:Mishra, A.K, McLellan, J.S.
Deposit date:2020-01-20
Release date:2020-02-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.524 Å)
Cite:Structure and Characterization of Crimean-Congo Hemorrhagic Fever Virus GP38.
J.Virol., 94, 2020
3LQE
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BU of 3lqe by Molmil
X-Ray Structure of the Murine Norovirus (MNV)-1 Capsid Protein Protruding (P) Domain
Descriptor: Capsid protein
Authors:Rubin, J.R, Stuckey, J.A.
Deposit date:2010-02-09
Release date:2010-04-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-resolution x-ray structure and functional analysis of the murine norovirus 1 capsid protein protruding domain.
J.Virol., 84, 2010
8GZ4
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BU of 8gz4 by Molmil
Crystal structure of MPXV phosphatase
Descriptor: Dual specificity protein phosphatase H1, PHOSPHATE ION
Authors:Yang, H.T, Wang, W, Huang, H.J, Ji, X.Y.
Deposit date:2022-09-25
Release date:2023-05-17
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Crystal structure of monkeypox H1 phosphatase, an antiviral drug target.
Protein Cell, 14, 2023
4M0Q
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BU of 4m0q by Molmil
Ebola virus VP24 structure
Descriptor: Membrane-associated protein VP24
Authors:Xu, W, Leung, D.W, Borek, D, Amarasinghe, G.K.
Deposit date:2013-08-01
Release date:2014-03-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.921 Å)
Cite:The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway.
Cell Rep, 6, 2014
6EHM
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BU of 6ehm by Molmil
Model of the Ebola virus nucleocapsid subunit from recombinant virus-like particles
Descriptor: Membrane-associated protein VP24, Nucleoprotein
Authors:Wan, W, Kolesnikova, L, Clarke, M, Koehler, A, Noda, T, Becker, S, Briggs, J.A.G.
Deposit date:2017-09-13
Release date:2017-11-08
Last modified:2019-12-04
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:Structure and assembly of the Ebola virus nucleocapsid.
Nature, 551, 2017
2WZL
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BU of 2wzl by Molmil
The Structure of the N-RNA Binding Domain of the Mokola virus Phosphoprotein
Descriptor: GLYCEROL, PHOSPHOPROTEIN
Authors:Assenberg, R, Delmas, O, Ren, J, Vidalain, P, Verma, A, Larrous, F, Graham, S, Tangy, F, Grimes, J, Bourhy, H.
Deposit date:2009-11-30
Release date:2009-12-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Structure of the N-RNA Binding Domain of the Mokola Virus Phosphoprotein
J.Virol., 84, 2010
7X45
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BU of 7x45 by Molmil
Grass carp interferon gamma related
Descriptor: Interferon gamma
Authors:Wang, J, Zou, J, Zhu, X.
Deposit date:2022-03-02
Release date:2022-09-14
Last modified:2023-04-19
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Novel Dimeric Architecture of an IFN-gamma-Related Cytokine Provides Insights into Subfunctionalization of Type II IFNs in Teleost Fish.
J Immunol., 209, 2022
5NCR
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BU of 5ncr by Molmil
OH1 from the Orf virus: a tyrosine phosphatase that displays distinct structural features and triple substrate specificity
Descriptor: PHOSPHATE ION, SULFATE ION, tyrosine phosphatase
Authors:Segovia, D, Haouz, A, Berois, M, Villarino, A, Andre-Leroux, G.
Deposit date:2017-03-06
Release date:2017-08-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:OH1 from Orf Virus: A New Tyrosine Phosphatase that Displays Distinct Structural Features and Triple Substrate Specificity.
J. Mol. Biol., 429, 2017
7U7N
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BU of 7u7n by Molmil
IL-27 quaternary receptor signaling complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ...
Authors:Caveney, N.A, Glassman, C.R, Jude, K.M, Tsutsumi, N, Garcia, K.C.
Deposit date:2022-03-07
Release date:2022-05-25
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Structure of the IL-27 quaternary receptor signaling complex.
Elife, 11, 2022
3LQ6
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BU of 3lq6 by Molmil
Crystal Structure of Murine Norovirus Protruding (P) Domain
Descriptor: Capsid protein
Authors:Rubin, J.R, Stuckey, J.A.
Deposit date:2010-02-08
Release date:2010-04-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-resolution x-ray structure and functional analysis of the murine norovirus 1 capsid protein protruding domain.
J.Virol., 84, 2010

 

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