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6QB5
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BU of 6qb5 by Molmil
Crystal structure of the N-terminal region of human cohesin subunit STAG1
Descriptor: Cohesin subunit SA-1, SODIUM ION
Authors:Newman, J.A, Katis, V.L, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2018-12-20
Release date:2019-02-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
Life Sci Alliance, 3, 2020
6R7O
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BU of 6r7o by Molmil
Crystal structure of the central region of human cohesin subunit STAG1
Descriptor: Cohesin subunit SA-1
Authors:Newman, J.A, katis, V.L, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-03-29
Release date:2019-04-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
Life Sci Alliance, 3, 2020
6RRK
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BU of 6rrk by Molmil
Crystal structure of the central region of human cohesin subunit STAG1 in complex with RAD21 peptide
Descriptor: Cohesin subunit SA-1, Double-strand-break repair protein rad21 homolog
Authors:Newman, J.A, katis, V.L, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-20
Release date:2019-06-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
Life Sci Alliance, 3, 2020
6RRC
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BU of 6rrc by Molmil
Crystal structure of the N-terminal region of human cohesin subunit STAG1 in complex with RAD21 peptide
Descriptor: Cohesin subunit SA-1, Double-strand-break repair protein rad21 homolog, SULFATE ION
Authors:Newman, J.A, Katis, V.L, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-17
Release date:2019-06-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
Life Sci Alliance, 3, 2020
7W1M
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BU of 7w1m by Molmil
Cryo-EM structure of human cohesin-CTCF-DNA complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cohesin subunit SA-1, ...
Authors:Shi, Z.B, Bai, X.C, Yu, H.
Deposit date:2021-11-19
Release date:2023-05-31
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:CTCF and R-loops are boundaries of cohesin-mediated DNA looping.
Mol.Cell, 83, 2023
6WG3
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BU of 6wg3 by Molmil
Cryo-EM structure of human Cohesin-NIPBL-DNA complex
Descriptor: Cohesin subunit SA-1, DNA (51-MER), Double-strand-break repair protein rad21 homolog, ...
Authors:Shi, Z.B, Gao, H, Bai, X.C, Yu, H.
Deposit date:2020-04-04
Release date:2020-05-20
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Cryo-EM structure of the human cohesin-NIPBL-DNA complex.
Science, 368, 2020
6WGE
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BU of 6wge by Molmil
Cryo-EM structure of human Cohesin-NIPBL-DNA complex without STAG1
Descriptor: DNA (43-MER), Double-strand-break repair protein rad21 homolog, MAGNESIUM ION, ...
Authors:Shi, Z.B, Gao, H, Bai, X.C, Yu, H.
Deposit date:2020-04-05
Release date:2020-05-20
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structure of the human cohesin-NIPBL-DNA complex.
Science, 368, 2020
5QSY
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BU of 5qsy by Molmil
PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z755044716
Descriptor: Cohesin subunit SA-1, N-ethyl-1H-1,2,3-triazole-4-carboxamide
Authors:Newman, J.A, Katis, V.L, Gavard, A.E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QSW
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BU of 5qsw by Molmil
PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z2856434884
Descriptor: 1-[4-(3-phenylpropyl)piperazin-1-yl]ethan-1-one, Cohesin subunit SA-1
Authors:Newman, J.A, Katis, V.L, Gavard, A.E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QSU
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BU of 5qsu by Molmil
PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z2856434926
Descriptor: 4-[(furan-2-yl)methyl]-1lambda~6~,4-thiazinane-1,1-dione, Cohesin subunit SA-1
Authors:Newman, J.A, Katis, V.L, Gavard, A.E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QSQ
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BU of 5qsq by Molmil
PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z396380540
Descriptor: Cohesin subunit SA-1, ~{N}-(cyclobutylmethyl)-1,5-dimethyl-pyrazole-4-carboxamide
Authors:Newman, J.A, Katis, V.L, Gavard, A.E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QSV
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BU of 5qsv by Molmil
PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z2856434783
Descriptor: Cohesin subunit SA-1, N-benzyl-1-(4-fluorophenyl)methanamine
Authors:Newman, J.A, Katis, V.L, Gavard, A.E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QSR
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BU of 5qsr by Molmil
PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z136583524
Descriptor: 2-methyl-N-(pyridin-4-yl)furan-3-carboxamide, Cohesin subunit SA-1
Authors:Newman, J.A, Katis, V.L, Gavard, A.E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.28 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QSZ
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BU of 5qsz by Molmil
PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z1267773786
Descriptor: Cohesin subunit SA-1, N-ethyl-6-methylpyridazin-3-amine
Authors:Newman, J.A, Katis, V.L, Gavard, A.E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QST
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BU of 5qst by Molmil
PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z2447286438
Descriptor: (3S)-N-methyl-N-phenylpyrrolidine-3-carboxamide, Cohesin subunit SA-1
Authors:Newman, J.A, Katis, V.L, Gavard, A.E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QSM
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BU of 5qsm by Molmil
PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z57261895
Descriptor: 2-cyclohexyl-N-(4H-1,2,4-triazol-4-yl)acetamide, Cohesin subunit SA-1
Authors:Newman, J.A, Katis, V.L, Gavard, A.E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QSX
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BU of 5qsx by Molmil
PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z2856434812
Descriptor: 4-[(3,4-dihydroisoquinolin-2(1H)-yl)methyl]phenol, Cohesin subunit SA-1
Authors:Newman, J.A, Katis, V.L, Gavard, A.E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-07-16
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QSO
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BU of 5qso by Molmil
PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z466628048
Descriptor: Cohesin subunit SA-1, N-[(4-methyl-1,3-thiazol-2-yl)methyl]-1H-pyrazole-5-carboxamide
Authors:Newman, J.A, Katis, V.L, Gavard, A.E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QSN
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BU of 5qsn by Molmil
PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z1272480091
Descriptor: (2R)-2-(methoxymethyl)-4-(pyridin-2-yl)morpholine, Cohesin subunit SA-1
Authors:Newman, J.A, Katis, V.L, Gavard, A.E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QSP
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BU of 5qsp by Molmil
PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z2856434929
Descriptor: 4-[(4-methylphenyl)methyl]-1,4-thiazinane 1,1-dioxide, Cohesin subunit SA-1
Authors:Newman, J.A, Katis, V.L, Gavard, A.E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QSS
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BU of 5qss by Molmil
PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z33452282
Descriptor: Cohesin subunit SA-1, N-(2-hydroxy-4-methylphenyl)-2-methylbenzamide
Authors:Newman, J.A, Katis, V.L, Gavard, A.E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:PanDDA analysis group deposition
To Be Published
6WG4
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BU of 6wg4 by Molmil
Crystal structure of human SMC1-SMC3 hinge domain heterodimer in south-open conformation
Descriptor: Structural maintenance of chromosomes protein, Structural maintenance of chromosomes protein 3
Authors:Shi, Z.B, Yu, H.
Deposit date:2020-04-04
Release date:2020-05-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Cryo-EM structure of the human cohesin-NIPBL-DNA complex.
Science, 368, 2020
6WG6
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BU of 6wg6 by Molmil
Crystal structure of human SMC1-SMC3 hinge domain heterodimer in north-open conformation
Descriptor: Structural maintenance of chromosomes protein, Structural maintenance of chromosomes protein 3, poly(dT)
Authors:Shi, Z.B, Yu, H.
Deposit date:2020-04-04
Release date:2020-05-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.54 Å)
Cite:Cryo-EM structure of the human cohesin-NIPBL-DNA complex.
Science, 368, 2020

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