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1KHX
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BU of 1khx by Molmil
Crystal structure of a phosphorylated Smad2
Descriptor: Smad2
Authors:Wu, J.-W, Hu, M, Chai, J, Seoane, J, Huse, M, Kyin, S, Muir, T.W, Fairman, R, Massague, J, Shi, Y.
Deposit date:2001-12-01
Release date:2002-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.
Mol.Cell, 8, 2001
1DEV
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BU of 1dev by Molmil
CRYSTAL STRUCTURE OF SMAD2 MH2 DOMAIN BOUND TO THE SMAD-BINDING DOMAIN OF SARA
Descriptor: MAD (mothers against decapentaplegic, Drosophila) homolog 2, Smad anchor for receptor activation
Authors:Shi, Y, Wu, G.
Deposit date:1999-11-15
Release date:2000-01-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of Smad2 recognition by the Smad anchor for receptor activation.
Science, 287, 2000
6M64
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BU of 6m64 by Molmil
Crystal structure of SMAD2 in complex with CBP
Descriptor: CBP, Mothers against decapentaplegic homolog 2
Authors:Miyazono, K, Ito, T, Wada, H, Tanokura, M.
Deposit date:2020-03-13
Release date:2020-11-25
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural basis for transcriptional coactivator recognition by SMAD2 in TGF-beta signaling.
Sci.Signal., 13, 2020
7CO1
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BU of 7co1 by Molmil
Crystal structure of SMAD2 in complex with wild-type CBP
Descriptor: CREB-binding protein, Mothers against decapentaplegic homolog 2
Authors:Miyazono, K, Wada, H, Ito, T, Tanokura, M.
Deposit date:2020-08-03
Release date:2020-11-25
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis for transcriptional coactivator recognition by SMAD2 in TGF-beta signaling.
Sci.Signal., 13, 2020
5XOD
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BU of 5xod by Molmil
Crystal structure of human Smad2-Ski complex
Descriptor: Mothers against decapentaplegic homolog 2, Ski oncogene
Authors:Miyazono, K, Moriwaki, S, Ito, T, Tanokura, M.
Deposit date:2017-05-27
Release date:2018-03-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Hydrophobic patches on SMAD2 and SMAD3 determine selective binding to cofactors
Sci Signal, 11, 2018
6H3R
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BU of 6h3r by Molmil
Crystal structure of Smad2 without exon -MH1 bound to the CAGAC site.
Descriptor: DNA (5'-D(P*GP*AP*GP*TP*GP*TP*CP*TP*GP*CP*AP*GP*AP*CP*AP*CP*TP*C)-3'), Mothers against decapentaplegic homolog, ZINC ION
Authors:Kaczmarska, Z, Marquez, J.A, Macias, M.J.
Deposit date:2018-07-19
Release date:2019-09-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-beta signaling
Genes Dev., 2020
5XOC
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BU of 5xoc by Molmil
Crystal structure of human Smad3-FoxH1 complex
Descriptor: Mothers against decapentaplegic homolog 3, Thioredoxin 1,Forkhead box protein H1
Authors:Miyazono, K, Ito, T, Tanokura, M.
Deposit date:2017-05-27
Release date:2018-03-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Hydrophobic patches on SMAD2 and SMAD3 determine selective binding to cofactors
Sci Signal, 11, 2018
6ZVQ
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BU of 6zvq by Molmil
Complex between SMAD2 MH2 domain and peptide from Ski corepressor
Descriptor: D(-)-TARTARIC ACID, GLYCEROL, Mothers against decapentaplegic homolog 2, ...
Authors:Purkiss, A.G, Kjaer, S, George, R, Hill, C.S.
Deposit date:2020-07-27
Release date:2021-06-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-beta responses through SKI stabilization.
Elife, 10, 2021
1U7V
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BU of 1u7v by Molmil
Crystal Structure of the phosphorylated Smad2/Smad4 heterotrimeric complex
Descriptor: Mothers against decapentaplegic homolog 2, Mothers against decapentaplegic homolog 4
Authors:Chacko, B.M, Qin, B.Y, Tiwari, A, Shi, G, Lam, S, Hayward, L.J, de Caestecker, M, Lin, K.
Deposit date:2004-08-04
Release date:2004-09-28
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of heteromeric smad protein assembly in tgf-Beta signaling
Mol.Cell, 15, 2004
5ZOJ
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BU of 5zoj by Molmil
Crystal structure of human SMAD2-MAN1 complex
Descriptor: Inner nuclear membrane protein Man1, Mothers against decapentaplegic homolog 2
Authors:Miyazono, K, Ohno, Y, Ito, T, Tanokura, M.
Deposit date:2018-04-13
Release date:2018-10-10
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Structural basis for receptor-regulated SMAD recognition by MAN1
Nucleic Acids Res., 46, 2018
6YIA
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BU of 6yia by Molmil
14-3-3 sigma in complex with SMAD2 pS465 peptide
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Kiehstaller, S, Graf, S, Hennig, S.
Deposit date:2020-04-01
Release date:2021-04-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Identification and characterization of 14-3-3/SMAD protein-protein-interactions
To Be Published
2LB3
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BU of 2lb3 by Molmil
Structure of the WW domain of PIN1 in complex with a human phosphorylated Smad3 derived peptide
Descriptor: Mothers against decapentaplegic homolog 2, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Authors:Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
3U5O
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BU of 3u5o by Molmil
Crystal structure of the complex of TRIM33 PHD-Bromo and H3(1-22)K9me3K14acK18ac histone peptide
Descriptor: E3 ubiquitin-protein ligase TRIM33, Histone H3.1, ZINC ION
Authors:Wang, Z, Patel, D.J.
Deposit date:2011-10-11
Release date:2012-01-18
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A poised chromatin platform for TGF-beta access to master regulators
Cell(Cambridge,Mass.), 147, 2011
3U5M
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BU of 3u5m by Molmil
Crystal structure of TRIM33 PHD-Bromo in the free state
Descriptor: CALCIUM ION, E3 ubiquitin-protein ligase TRIM33, ZINC ION
Authors:Wang, Z, Patel, D.J.
Deposit date:2011-10-11
Release date:2012-01-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:A poised chromatin platform for TGF-beta access to master regulators
Cell(Cambridge,Mass.), 147, 2011
3U5P
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BU of 3u5p by Molmil
Crystal structure of the complex of TRIM33 PHD-Bromo and H3(1-28)K9me3K14acK18acK23ac histone peptide
Descriptor: E3 ubiquitin-protein ligase TRIM33, Histone H3.1, ZINC ION
Authors:Wang, Z, Patel, D.J.
Deposit date:2011-10-11
Release date:2012-01-18
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A poised chromatin platform for TGF-beta access to master regulators
Cell(Cambridge,Mass.), 147, 2011
3U5N
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BU of 3u5n by Molmil
Crystal structure of the complex of TRIM33 PHD-Bromo and H3(1-20)K9me3K14ac histone peptide
Descriptor: E3 ubiquitin-protein ligase TRIM33, Histone H3.1, ZINC ION
Authors:Wang, Z, Patel, D.J.
Deposit date:2011-10-11
Release date:2012-01-18
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A Poised Chromatin Platform for TGF-beta access to master regulators
Cell(Cambridge,Mass.), 147, 2011
5OD6
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BU of 5od6 by Molmil
Crystal structure of Smad3-MH1 bound to the GGCGC site.
Descriptor: DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP*GP*CP*A)-3'), Mothers against decapentaplegic homolog 3, ZINC ION
Authors:Kaczmarska, Z, Marquez, J.A, Macias, M.J.
Deposit date:2017-07-04
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.
Nat Commun, 8, 2017
5ODG
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BU of 5odg by Molmil
Crystal structure of Smad3-MH1 bound to the GGCT site.
Descriptor: CHLORIDE ION, DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP*A)-3'), Mothers against decapentaplegic homolog 3, ...
Authors:Kaczmarska, Z, Marquez, J.A, Macias, M.J.
Deposit date:2017-07-05
Release date:2017-11-15
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.
Nat Commun, 8, 2017
1IAS
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BU of 1ias by Molmil
CYTOPLASMIC DOMAIN OF UNPHOSPHORYLATED TYPE I TGF-BETA RECEPTOR CRYSTALLIZED WITHOUT FKBP12
Descriptor: SULFATE ION, TGF-BETA RECEPTOR TYPE I
Authors:Huse, M, Muir, T.W, Chen, Y.-G, Kuriyan, J, Massague, J.
Deposit date:2001-03-23
Release date:2001-10-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The TGF beta receptor activation process: an inhibitor- to substrate-binding switch.
Mol.Cell, 8, 2001
6FQP
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BU of 6fqp by Molmil
Crystal structure of TALE homeobox domain transcription factor TGIF1 with its consensus DNA
Descriptor: CALCIUM ION, DNA (5'-D(P*AP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*T)-3'), Homeobox protein TGIF1
Authors:Guca, E, Macias, M.J.
Deposit date:2018-02-14
Release date:2018-07-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling.
Nucleic Acids Res., 46, 2018
6FQQ
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BU of 6fqq by Molmil
Crystal structure of TALE homeobox domain transcription factor TGIF1 double alanine mutant bound to its consensus DNA
Descriptor: CHLORIDE ION, DNA (5'-D(P*AP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*T)-3'), Homeobox protein TGIF1
Authors:Guca, E, Macias, M.J.
Deposit date:2018-02-14
Release date:2018-07-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.25000262 Å)
Cite:TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling.
Nucleic Acids Res., 46, 2018
5MEZ
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BU of 5mez by Molmil
Crystal structure of Smad4-MH1 bound to the GGCT site.
Descriptor: CHLORIDE ION, DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP*A)-3'), MH1 domain of human Smad4, ...
Authors:Kaczmarska, Z, Freier, R, Marquez, J.A, Macias, M.J.
Deposit date:2016-11-16
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.
Nat Commun, 8, 2017
5MEY
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BU of 5mey by Molmil
Crystal structure of Smad4-MH1 bound to the GGCGC site.
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ...
Authors:Kaczmarska, Z, Freier, R, Marquez, J.A, Macias, M.J.
Deposit date:2016-11-16
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.
Nat Commun, 8, 2017
5MF0
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BU of 5mf0 by Molmil
Crystal structure of Smad4-MH1 bound to the GGCCG site.
Descriptor: CHLORIDE ION, DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP*CP*GP*T)-3'), MH1 domain of human Smad4, ...
Authors:Kaczmarska, Z, Freier, R, Marquez, J.A, Macias, M.J.
Deposit date:2016-11-16
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.
Nat Commun, 8, 2017
5NM9
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BU of 5nm9 by Molmil
Crystal structure of the placozoa Trichoplax adhaerens Smad4-MH1 bound to the GGCGC site.
Descriptor: DNA (5'-D(P*AP*TP*GP*CP*GP*GP*GP*CP*GP*CP*GP*CP*CP*CP*GP*CP*AP*T)-3'), Mothers against decapentaplegic homolog, ZINC ION
Authors:Kaczmarska, Z, Freier, R, Marquez, J.A, Macias, M.J.
Deposit date:2017-04-05
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.
Nat Commun, 8, 2017

 

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