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2LWW
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BU of 2lww by Molmil
NMR structure of RelA-TAD/CBP-TAZ1 complex
Descriptor: CREB-binding protein, Nuclear transcription factor RelA, ZINC ION
Authors:Mukherjee, S.P, Ghosh, G, Wright, P.E.
Deposit date:2012-08-07
Release date:2013-09-11
Last modified:2013-09-18
Method:SOLUTION NMR
Cite:Analysis of the RelA:CBP/p300 Interaction Reveals Its Involvement in NF-kappa B-Driven Transcription.
Plos Biol., 11, 2013
1VJ7
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BU of 1vj7 by Molmil
Crystal structure of the bifunctional catalytic fragment of RelSeq, the RelA/SpoT homolog from Streptococcus equisimilis.
Descriptor: Bifunctional RELA/SPOT, GUANOSINE 5'-DIPHOSPHATE 2':3'-CYCLIC MONOPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Hogg, T, Mechold, U, Malke, H, Cashel, M, Hilgenfeld, R.
Deposit date:2004-02-03
Release date:2004-05-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response.
Cell(Cambridge,Mass.), 117, 2004
5L3P
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BU of 5l3p by Molmil
Cryo-EM structure of stringent response factor RelA bound to ErmCL-stalled ribosome complex
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Arenz, S, Wilson, D.N.
Deposit date:2016-05-24
Release date:2016-07-20
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis.
Nucleic Acids Res., 44, 2016
5KPX
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BU of 5kpx by Molmil
Structure of RelA bound to ribosome in presence of A/R tRNA (Structure IV)
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Loveland, A.B, Bah, E, Madireddy, R, Zhang, Y, Brilot, A.F, Grigorieff, N, Korostelev, A.A.
Deposit date:2016-07-05
Release date:2016-09-28
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Ribosome•RelA structures reveal the mechanism of stringent response activation.
Elife, 5, 2016
5KPV
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BU of 5kpv by Molmil
Structure of RelA bound to ribosome in presence of A/R tRNA (Structure II)
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Loveland, A.B, Bah, E, Madireddy, R, Zhang, Y, Brilot, A.F, Grigorieff, N, Korostelev, A.A.
Deposit date:2016-07-05
Release date:2016-09-28
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Ribosome•RelA structures reveal the mechanism of stringent response activation.
Elife, 5, 2016
5KPW
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BU of 5kpw by Molmil
Structure of RelA bound to ribosome in presence of A/R tRNA (Structure III)
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Loveland, A.B, Bah, E, Madireddy, R, Zhang, Y, Brilot, A.F, Grigorieff, N, Korostelev, A.A.
Deposit date:2016-07-05
Release date:2016-09-28
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Ribosome•RelA structures reveal the mechanism of stringent response activation.
Elife, 5, 2016
5KPS
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BU of 5kps by Molmil
Structure of RelA bound to ribosome in absence of A/R tRNA (Structure I)
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Loveland, A.B, Bah, E, Madireddy, R, Zhang, Y, Brilot, A.F, Grigorieff, N, Korostelev, A.A.
Deposit date:2016-07-05
Release date:2016-09-28
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Ribosome•RelA structures reveal the mechanism of stringent response activation.
Elife, 5, 2016
8FR8
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BU of 8fr8 by Molmil
Structure of Mycobacterium smegmatis Rsh bound to a 70S translation initiation complex
Descriptor: 16S rRNA (1511-MER), 23S rRNA (3119-MER), 30S ribosomal protein S10, ...
Authors:Majumdar, S, Sharma, M.R, Manjari, S.R, Banavali, N.K, Agrawal, R.K.
Deposit date:2023-01-06
Release date:2023-05-17
Last modified:2023-06-28
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Starvation sensing by mycobacterial RelA/SpoT homologue through constitutive surveillance of translation.
Proc.Natl.Acad.Sci.USA, 120, 2023
5U01
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BU of 5u01 by Molmil
Cooperative DNA binding by two RelA dimers
Descriptor: DNA (27-MER), Transcription factor p65
Authors:Ghosh, G, Huang, D.
Deposit date:2016-11-22
Release date:2017-09-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor kappa B are not correlated.
J. Biol. Chem., 292, 2017
3GUT
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BU of 3gut by Molmil
Crystal structure of a higher-order complex of p50:RelA bound to the HIV-1 LTR
Descriptor: HIV-LTR Core Forward Strand, HIV-LTR Core Reverse Strand, Nuclear factor NF-kappa-B p105 subunit, ...
Authors:Stroud, J.C, Oltman, A.J, Han, A, Bates, D.L, Chen, L.
Deposit date:2009-03-30
Release date:2009-09-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.59 Å)
Cite:Structural basis of HIV-1 activation by NF-kappaB--a higher-order complex of p50:RelA bound to the HIV-1 LTR.
J.Mol.Biol., 393, 2009
4KV4
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BU of 4kv4 by Molmil
Brd4 Bromodomain 2 in Complex with Acetylated Rel Peptide
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Bromodomain-containing protein 4, Rel Peptide
Authors:Zhang, H, Nair, S.K.
Deposit date:2013-05-22
Release date:2013-06-26
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Brd4 maintains constitutively active NF-kappa B in cancer cells by binding to acetylated RelA.
Oncogene, 33, 2014
4KV1
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BU of 4kv1 by Molmil
Crystal Structure of Brd4 Bromodomain 1 in Complex with Acetylated Rel Peptide
Descriptor: Bromodomain-containing protein 4, Rel peptide
Authors:Zhang, H, Nair, S.K.
Deposit date:2013-05-22
Release date:2013-06-26
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Brd4 maintains constitutively active NF-kappa B in cancer cells by binding to acetylated RelA.
Oncogene, 33, 2014
5IQR
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BU of 5iqr by Molmil
Structure of RelA bound to the 70S ribosome
Descriptor: 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ...
Authors:Brown, A, Fernandez, I.S, Gordiyenko, Y, Ramakrishnan, V.
Deposit date:2016-03-11
Release date:2016-05-04
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Ribosome-dependent activation of stringent control.
Nature, 534, 2016
6HTQ
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BU of 6htq by Molmil
Stringent response control by a bifunctional RelA enzyme in the presence and absence of the ribosome
Descriptor: 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Wilson, D.N, Abdelshahid, M.
Deposit date:2018-10-04
Release date:2019-10-23
Last modified:2020-09-30
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel.
Cell Rep, 32, 2020
3RC0
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BU of 3rc0 by Molmil
Human SETD6 in complex with RelA Lys310 peptide
Descriptor: 1,2-ETHANEDIOL, N-lysine methyltransferase SETD6, S-ADENOSYLMETHIONINE, ...
Authors:Chang, Y, Levy, D, Horton, J.R, Peng, J, Zhang, X, Gozani, O, Cheng, X.
Deposit date:2011-03-30
Release date:2011-05-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling.
Nucleic Acids Res., 39, 2011
3QXY
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BU of 3qxy by Molmil
Human SETD6 in complex with RelA Lys310
Descriptor: 1,2-ETHANEDIOL, N-lysine methyltransferase SETD6, S-ADENOSYLMETHIONINE, ...
Authors:Chang, Y, Levy, D, Horton, J.R, Peng, J, Zhang, X, Gozani, O, Cheng, X.
Deposit date:2011-03-02
Release date:2011-05-25
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling.
Nucleic Acids Res., 39, 2011
5XNX
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BU of 5xnx by Molmil
Crystallographic structure of the enzymatically active N-terminal domain of the Rel protein from Mycobacterium tuberculosis
Descriptor: Bifunctional (p)ppGpp synthase/hydrolase RelA, MAGNESIUM ION
Authors:Singal, B, Balakrishna, A.M, Manimekalai, M.S.S, Nartey, W, Gruber, G.
Deposit date:2017-05-24
Release date:2017-07-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Crystallographic and solution structure of the N-terminal domain of the Rel protein from Mycobacterium tuberculosis
FEBS Lett., 591, 2017
6S2U
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BU of 6s2u by Molmil
Structure of the catalytic domain of T. thermophilus Rel in complex with AMP and ppGpp
Descriptor: (P)ppGpp synthetase I, SpoT/RelA, ADENOSINE MONOPHOSPHATE, ...
Authors:Garcia-Pino, A.
Deposit date:2019-06-22
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes.
Nat.Chem.Biol., 16, 2020
6S2T
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BU of 6s2t by Molmil
Structure of the N-terminal catalytic region of T. thermophilus Rel bound to ppGpp
Descriptor: (P)ppGpp synthetase I, SpoT/RelA, CHLORIDE ION, ...
Authors:Garcia-Pino, A.
Deposit date:2019-06-22
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes.
Nat.Chem.Biol., 16, 2020
6S2V
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BU of 6s2v by Molmil
Structure of the N-terminal catalytic region of T. thermophilus Rel
Descriptor: (P)ppGpp synthetase I, SpoT/RelA, CHLORIDE ION, ...
Authors:Garcia-Pino, A.
Deposit date:2019-06-22
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes.
Nat.Chem.Biol., 16, 2020
6YXA
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BU of 6yxa by Molmil
Structure of the bifunctional Rel enzyme from B. subtilis
Descriptor: GTP pyrophosphokinase, MANGANESE (II) ION
Authors:Pausch, P, Bange, G.
Deposit date:2020-04-30
Release date:2020-09-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel.
Cell Rep, 32, 2020
6DCX
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BU of 6dcx by Molmil
iASPP-PP-1c structure and targeting of p53
Descriptor: RelA-associated inhibitor, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Authors:Glover, J.N.M, Zhou, Y, Edwards, R.A.
Deposit date:2018-05-08
Release date:2019-05-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.408 Å)
Cite:Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis.
Structure, 27, 2019
2VGE
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BU of 2vge by Molmil
Crystal structure of the C-terminal region of human iASPP
Descriptor: RELA-ASSOCIATED INHIBITOR
Authors:Robinson, R.A, Lu, X, Jones, E.Y, Siebold, C.
Deposit date:2007-11-12
Release date:2008-02-05
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Biochemical and Structural Studies of Aspp Proteins Reveal Differential Binding to P53, P63 and P73
Structure, 16, 2008
8ACU
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BU of 8acu by Molmil
Structure of Bacillus subtilis Rel in complex with DarB
Descriptor: CBS domain-containing protein, GTP pyrophosphokinase, MANGANESE (II) ION
Authors:Garcia-Pino, A.
Deposit date:2022-07-06
Release date:2023-07-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Structure of Bacillus subtilis Rel in complex with DarB
To Be Published
1RAM
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BU of 1ram by Molmil
A NOVEL DNA RECOGNITION MODE BY NF-KB P65 HOMODIMER
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, DNA (5'-D(*CP*GP*GP*CP*TP*GP*GP*AP*AP*AP*TP*TP*TP*CP*CP*AP*GP*CP*CP*G)-3'), PROTEIN (TRANSCRIPTION FACTOR NF-KB P65)
Authors:Chen, Y.-Q, Ghosh, S, Ghosh, G.
Deposit date:1997-11-22
Release date:1998-05-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A novel DNA recognition mode by the NF-kappa B p65 homodimer.
Nat.Struct.Biol., 5, 1998

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