Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6RRK
DownloadVisualize
BU of 6rrk by Molmil
Crystal structure of the central region of human cohesin subunit STAG1 in complex with RAD21 peptide
Descriptor: Cohesin subunit SA-1, Double-strand-break repair protein rad21 homolog
Authors:Newman, J.A, katis, V.L, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-20
Release date:2019-06-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
Life Sci Alliance, 3, 2020
6RRC
DownloadVisualize
BU of 6rrc by Molmil
Crystal structure of the N-terminal region of human cohesin subunit STAG1 in complex with RAD21 peptide
Descriptor: Cohesin subunit SA-1, Double-strand-break repair protein rad21 homolog, SULFATE ION
Authors:Newman, J.A, Katis, V.L, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-17
Release date:2019-06-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
Life Sci Alliance, 3, 2020
6YUF
DownloadVisualize
BU of 6yuf by Molmil
Cohesin complex with loader gripping DNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cohesin subunit rad21, ...
Authors:Higashi, T.L, Eickhoff, P, Sousa, J.S, Costa, A, Uhlmann, F.
Deposit date:2020-04-27
Release date:2020-08-19
Last modified:2020-09-30
Method:ELECTRON MICROSCOPY (3.94 Å)
Cite:A Structure-Based Mechanism for DNA Entry into the Cohesin Ring.
Mol.Cell, 79, 2020
7ZJS
DownloadVisualize
BU of 7zjs by Molmil
Structural basis of centromeric cohesion protection by SGO1
Descriptor: Cohesin subunit SA-2, Double-strand-break repair protein rad21 homolog, Shugoshin 1
Authors:Patel, A, Panne, D.
Deposit date:2022-04-11
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Structural basis of centromeric cohesion protection.
Nat.Struct.Mol.Biol., 30, 2023
7W1M
DownloadVisualize
BU of 7w1m by Molmil
Cryo-EM structure of human cohesin-CTCF-DNA complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cohesin subunit SA-1, ...
Authors:Shi, Z.B, Bai, X.C, Yu, H.
Deposit date:2021-11-19
Release date:2023-05-31
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:CTCF and R-loops are boundaries of cohesin-mediated DNA looping.
Mol.Cell, 83, 2023
6WG3
DownloadVisualize
BU of 6wg3 by Molmil
Cryo-EM structure of human Cohesin-NIPBL-DNA complex
Descriptor: Cohesin subunit SA-1, DNA (51-MER), Double-strand-break repair protein rad21 homolog, ...
Authors:Shi, Z.B, Gao, H, Bai, X.C, Yu, H.
Deposit date:2020-04-04
Release date:2020-05-20
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Cryo-EM structure of the human cohesin-NIPBL-DNA complex.
Science, 368, 2020
6WGE
DownloadVisualize
BU of 6wge by Molmil
Cryo-EM structure of human Cohesin-NIPBL-DNA complex without STAG1
Descriptor: DNA (43-MER), Double-strand-break repair protein rad21 homolog, MAGNESIUM ION, ...
Authors:Shi, Z.B, Gao, H, Bai, X.C, Yu, H.
Deposit date:2020-04-05
Release date:2020-05-20
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structure of the human cohesin-NIPBL-DNA complex.
Science, 368, 2020
6QNX
DownloadVisualize
BU of 6qnx by Molmil
Structure of the SA2/SCC1/CTCF complex
Descriptor: Cohesin subunit SA-2, Double-strand-break repair protein rad21 homolog, Transcriptional repressor CTCF
Authors:Li, Y, Muir, K.W, Panne, D.
Deposit date:2019-02-12
Release date:2020-01-22
Last modified:2020-04-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structural basis for cohesin-CTCF-anchored loops.
Nature, 578, 2020
4PJW
DownloadVisualize
BU of 4pjw by Molmil
crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion protein 1 (Scc1), with bound MES
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cohesin subunit SA-2, Double-strand-break repair protein rad21 homolog
Authors:Hara, K, Chen, Z, Tomchick, D.R, Yu, H.
Deposit date:2014-05-12
Release date:2014-08-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.
Nat.Struct.Mol.Biol., 21, 2014
4PK7
DownloadVisualize
BU of 4pk7 by Molmil
crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion protein 1 (Scc1) with bound MES, native proteins
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cohesin subunit SA-2, Double-strand-break repair protein rad21 homolog
Authors:Hara, K, Chen, Z, Tomchick, D.R, Yu, H.
Deposit date:2014-05-13
Release date:2014-09-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.
Nat.Struct.Mol.Biol., 21, 2014
4PJU
DownloadVisualize
BU of 4pju by Molmil
crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion protein 1 (Scc1)
Descriptor: Cohesin subunit SA-2, Double-strand-break repair protein rad21 homolog
Authors:Hara, K, Chen, Z, Tomchick, D.R, Yu, H.
Deposit date:2014-05-12
Release date:2014-08-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.
Nat.Struct.Mol.Biol., 21, 2014
6QB5
DownloadVisualize
BU of 6qb5 by Molmil
Crystal structure of the N-terminal region of human cohesin subunit STAG1
Descriptor: Cohesin subunit SA-1, SODIUM ION
Authors:Newman, J.A, Katis, V.L, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2018-12-20
Release date:2019-02-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
Life Sci Alliance, 3, 2020
6R7O
DownloadVisualize
BU of 6r7o by Molmil
Crystal structure of the central region of human cohesin subunit STAG1
Descriptor: Cohesin subunit SA-1
Authors:Newman, J.A, katis, V.L, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-03-29
Release date:2019-04-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
Life Sci Alliance, 3, 2020
5D1C
DownloadVisualize
BU of 5d1c by Molmil
Crystal structure of D233G-Y306F HDAC8 in complex with a tetrapeptide substrate
Descriptor: GLYCEROL, HDAC8 Fluor de Lys tetrapeptide substrate, Histone deacetylase 8, ...
Authors:Decroos, C, Christianson, N.H, Gullett, L.E, Bowman, C.M, Christianson, K.E, Deardorff, M.A, Christianson, D.W.
Deposit date:2015-08-04
Release date:2015-10-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.422 Å)
Cite:Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
7NJ0
DownloadVisualize
BU of 7nj0 by Molmil
CryoEM structure of the human Separase-Cdk1-cyclin B1-Cks1 complex
Descriptor: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 1, G2/mitotic-specific cyclin-B1,G2/mitotic-specific cyclin-B1, ...
Authors:Yu, J, Raia, P, Ghent, C.M, Raisch, T, Sadian, Y, Barford, D, Raunser, S, Morgan, D.O, Boland, A.
Deposit date:2021-02-14
Release date:2021-08-04
Last modified:2021-08-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis of human separase regulation by securin and CDK1-cyclin B1.
Nature, 596, 2021
7NJ1
DownloadVisualize
BU of 7nj1 by Molmil
CryoEM structure of the human Separase-Securin complex
Descriptor: Securin, Separin
Authors:Yu, J, Raia, P, Ghent, C.M, Raisch, T, Sadian, Y, Barford, D, Raunser, S, Morgan, D.O, Boland, A.
Deposit date:2021-02-14
Release date:2021-08-04
Last modified:2021-08-18
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of human separase regulation by securin and CDK1-cyclin B1.
Nature, 596, 2021
5D1B
DownloadVisualize
BU of 5d1b by Molmil
Crystal structure of G117E HDAC8 in complex with TSA
Descriptor: Histone deacetylase 8, POTASSIUM ION, TRICHOSTATIN A, ...
Authors:Decroos, C, Christianson, N.H, Gullett, L.E, Bowman, C.M, Christianson, K.E, Deardorff, M.A, Christianson, D.W.
Deposit date:2015-08-04
Release date:2015-10-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
5D1D
DownloadVisualize
BU of 5d1d by Molmil
Crystal structure of P91L-Y306F HDAC8 in complex with a tetrapeptide substrate
Descriptor: HDAC8 Fluor de Lys tetrapeptide substrate, Histone deacetylase 8, POTASSIUM ION, ...
Authors:Decroos, C, Christianson, N.H, Gullett, L.E, Bowman, C.M, Christianson, K.E, Deardorff, M.A, Christianson, D.W.
Deposit date:2015-08-04
Release date:2015-10-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.011 Å)
Cite:Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
6QPQ
DownloadVisualize
BU of 6qpq by Molmil
The structure of the cohesin head module elucidates the mechanism of ring opening
Descriptor: Sister chromatid cohesion protein 1, Structural maintenance of chromosomes protein,Structural maintenance of chromosomes protein
Authors:Li, Y, Muir, K.W, Panne, D.
Deposit date:2019-02-14
Release date:2020-02-05
Last modified:2020-03-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of the cohesin ATPase elucidates the mechanism of SMC-kleisin ring opening.
Nat.Struct.Mol.Biol., 27, 2020
4QA5
DownloadVisualize
BU of 4qa5 by Molmil
Crystal structure of A188T/Y306F HDAC8 in complex with a tetrapeptide substrate
Descriptor: 7-AMINO-4-METHYL-CHROMEN-2-ONE, GLYCEROL, Histone deacetylase 8, ...
Authors:Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA6
DownloadVisualize
BU of 4qa6 by Molmil
Crystal structure of I243N/Y306F HDAC8 in complex with a tetrapeptide substrate
Descriptor: 7-AMINO-4-METHYL-CHROMEN-2-ONE, GLYCEROL, Histone deacetylase 8, ...
Authors:Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.053 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA2
DownloadVisualize
BU of 4qa2 by Molmil
Crystal structure of I243N HDAC8 in complex with SAHA
Descriptor: GLYCEROL, Histone deacetylase 8, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ...
Authors:Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.377 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA1
DownloadVisualize
BU of 4qa1 by Molmil
Crystal structure of A188T HDAC8 in complex with M344
Descriptor: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, GLYCEROL, Histone deacetylase 8, ...
Authors:Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA4
DownloadVisualize
BU of 4qa4 by Molmil
Crystal structure of H334R HDAC8 in complex with M344
Descriptor: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, GLYCEROL, Histone deacetylase 8, ...
Authors:Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA0
DownloadVisualize
BU of 4qa0 by Molmil
Crystal structure of C153F HDAC8 in complex with SAHA
Descriptor: GLYCEROL, Histone deacetylase 8, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ...
Authors:Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.242 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014

 

12>

217157

PDB entries from 2024-03-13

PDB statisticsPDBj update infoContact PDBjnumon