PDB: 106 resultsInfo pagesStatus searchChemie searchBIRD

---

1ORI	Structure of the predominant protein arginine methyltransferase PRMT1 Descriptor: Protein arginine N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, UNKNOWN LIGAND Authors: Zhang, X, Cheng, X. Deposit date: 2003-03-13 Release date: 2003-05-27 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of the Predominant Protein Arginine Methyltransferase PRMT1 and Analysis of its Binding to Substrate Peptides Structure, 11, 2003
1ORH	Structure of the Predominant Protein Arginine Methyltransferase PRMT1 Descriptor: GLYCEROL, Protein arginine N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ... Authors: Zhang, X, Cheng, X. Deposit date: 2003-03-13 Release date: 2003-08-26 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.64 Å) Cite: Structure of the Predominant Protein Arginine Methyltransferase PRMT1 and Analysis of Its Binding to Substrate Peptides Structure, 11, 2003
1OR8	Structure of the Predominant protein arginine methyltransferase PRMT1 Descriptor: GLYCEROL, Protein arginine N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ... Authors: Zhang, X, Cheng, X. Deposit date: 2003-03-12 Release date: 2003-08-26 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structure of the Predominant Protein Arginine Methyltransferase PRMT1 and Analysis of Its Binding to Substrate Peptides Structure, 11, 2003
3Q7E	Crystal Structure of rat Protein Arginine Methyltransferase 1 (PRMT1)M48L mutant Descriptor: MAGNESIUM ION, Protein arginine N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE Authors: Johnson, S.J, Porter, P.J, Hevel, J.M. Deposit date: 2011-01-04 Release date: 2011-06-22 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Investigation of the molecular origins of protein-arginine methyltransferase I (PRMT1) product specificity reveals a role for two conserved methionine residues. J.Biol.Chem., 286, 2011
8DUR	Crystal structure of apo protein arginine N-methyltransferase 1 (PRMT1) from Naegleria fowleri Descriptor: Protein arginine N-methyltransferase 1 (PRMT1) Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2022-07-27 Release date: 2022-08-10 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Crystal structure of apo protein arginine N-methyltransferase 1 (PRMT1) from Naegleria fowleri To be published
8FT7	Crystal structure of SAH bound protein arginine N-methyltransferase 1 (PRMT1) from Naegleria fowleri Descriptor: PUA domain-containing protein, S-ADENOSYL-L-HOMOCYSTEINE Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-01-11 Release date: 2023-01-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal structure of SAH bound protein arginine N-methyltransferase 1 (PRMT1) from Naegleria fowleri To be published
6S74	Crystal structure of CARM1 in complex with inhibitor UM305 Descriptor: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-azanylpropyl-[3-(pyrimidin-2-ylamino)propyl]amino]methyl]oxolane-3,4-diol, GLYCEROL, Histone-arginine methyltransferase CARM1 Authors: Gunnell, E.A, Muhsen, U, Dowden, J, Dreveny, I. Deposit date: 2019-07-04 Release date: 2020-03-04 Last modified: 2020-03-11 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4). Biochem.J., 477, 2020
6S77	Crystal structure of CARM1 N265Y mutant in complex with inhibitor AA183 Descriptor: (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-(pyridin-2-ylamino)propyl]amino]-2-azanyl-butanoic acid, Histone-arginine methyltransferase CARM1 Authors: Gunnell, E.A, Muhsen, U, Dowden, J, Dreveny, I. Deposit date: 2019-07-04 Release date: 2020-03-04 Last modified: 2020-03-11 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4). Biochem.J., 477, 2020
6S7C	Crystal structure of CARM1 in complex with inhibitor UM079 Descriptor: 1-[3-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]propyl]guanidine, Histone-arginine methyltransferase CARM1 Authors: Gunnell, E.A, Muhsen, U, Dowden, J, Dreveny, I. Deposit date: 2019-07-04 Release date: 2020-03-04 Last modified: 2020-03-11 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4). Biochem.J., 477, 2020
6S71	Crystal structure of CARM1 in complex with inhibitor WH5C Descriptor: (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(5-carbamimidamidopentyl)amino]-2-azanyl-butanoic acid, GLYCEROL, Histone-arginine methyltransferase CARM1 Authors: Gunnell, E.A, Muhsen, U, Dowden, J, Dreveny, I. Deposit date: 2019-07-04 Release date: 2020-03-04 Last modified: 2020-03-11 Method: X-RAY DIFFRACTION (2.062 Å) Cite: Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4). Biochem.J., 477, 2020
6S7B	Crystal structure of CARM1 in complex with inhibitor UM249 Descriptor: 1-[4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]butyl]guanidine, Histone-arginine methyltransferase CARM1 Authors: Gunnell, E.A, Muhsen, U, Dowden, J, Dreveny, I. Deposit date: 2019-07-04 Release date: 2020-03-04 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.659 Å) Cite: Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4). Biochem.J., 477, 2020
6S7A	Crystal structure of CARM1 in complex with inhibitor AA175 Descriptor: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-azanylpropyl-[3-(pyridin-2-ylamino)propyl]amino]methyl]oxolane-3,4-diol, GLYCEROL, Histone-arginine methyltransferase CARM1 Authors: Gunnell, E.A, Al-Noori, A, Dowden, J, Dreveny, I. Deposit date: 2019-07-04 Release date: 2020-03-04 Last modified: 2020-03-11 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4). Biochem.J., 477, 2020
6S70	Crystal structure of CARM1 in complex with inhibitor UM251 Descriptor: 1-[5-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]pentyl]guanidine, GLYCEROL, Histone-arginine methyltransferase CARM1 Authors: Gunnell, E.A, Muhsen, U, Dowden, J, Dreveny, I. Deposit date: 2019-07-04 Release date: 2020-03-04 Last modified: 2020-03-11 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4). Biochem.J., 477, 2020
6S79	Crystal structure of CARM1 in complex with inhibitor AA183 Descriptor: (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-(pyridin-2-ylamino)propyl]amino]-2-azanyl-butanoic acid, GLYCEROL, Histone-arginine methyltransferase CARM1 Authors: Gunnell, E.A, Al-Noori, A, Dowden, J, Dreveny, I. Deposit date: 2019-07-04 Release date: 2020-03-04 Last modified: 2020-03-11 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4). Biochem.J., 477, 2020
6DNZ	Trypanosoma brucei PRMT1 enzyme-prozyme heterotetrameric complex with AdoHcy Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Arginine N-methyltransferase, putative, ... Authors: Hashimoto, H, Kafkova, L, Jordan, K, Read, L.K, Debler, E.W. Deposit date: 2018-06-08 Release date: 2019-06-12 Last modified: 2020-02-12 Method: X-RAY DIFFRACTION (2.384 Å) Cite: Structural Basis of Protein Arginine Methyltransferase Activation by a Catalytically Dead Homolog (Prozyme). J.Mol.Biol., 432, 2020
6NT2	type 1 PRMT in complex with the inhibitor GSK3368715 Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, N~1~-({5-[4,4-bis(ethoxymethyl)cyclohexyl]-1H-pyrazol-4-yl}methyl)-N~1~,N~2~-dimethylethane-1,2-diamine, ... Authors: Concha, N.O. Deposit date: 2019-01-28 Release date: 2019-07-10 Last modified: 2019-07-24 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss. Cancer Cell, 36, 2019
8ONS	TAF15 amyloid fold in atypical FTLD - Individual 1 Descriptor: TATA-binding protein-associated factor 2N Authors: Tetter, S, Ryskeldi-Falcon, B. Deposit date: 2023-04-03 Release date: 2023-12-06 Last modified: 2024-02-07 Method: ELECTRON MICROSCOPY (1.97 Å) Cite: TAF15 amyloid filaments in frontotemporal lobar degeneration. Nature, 625, 2024
4X41	Crystal Structure of Protein Arginine Methyltransferase PRMT8 Descriptor: Protein arginine N-methyltransferase 8, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lee, W.C, Ho, M.C. Deposit date: 2014-12-02 Release date: 2015-11-18 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Protein Arginine Methyltransferase 8: Tetrameric Structure and Protein Substrate Specificity Biochemistry, 54, 2015
2F3J	The solution structure of the REF2-I mRNA export factor (residues 1-155). Descriptor: RNA and export factor binding protein 2 Authors: Golovanov, A.P, Hautbergue, G.M, Wilson, S.A, Lian, L.Y. Deposit date: 2005-11-21 Release date: 2006-10-31 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA. Rna, 12, 2006
7T2X	Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with 2-chloro-4-((4-hydroxybenzyl)amino)-5-phenylthieno[2,3-d]pyrimidin-6-ol and GRIP Peptide Descriptor: Estrogen receptor, Nuclear receptor coactivator 2, S-(2-chloro-6-{[(4-hydroxyphenyl)methyl]amino}pyrimidin-4-yl) phenylethanethioate Authors: Joiner, C, Sammeta, V.K.R, Norris, J.D, McDonnell, D.P, Wilson, T.M, Fanning, S.W. Deposit date: 2021-12-06 Release date: 2022-06-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A New Chemotype of Chemically Tractable Nonsteroidal Estrogens Based on a Thieno[2,3- d ]pyrimidine Core. Acs Med.Chem.Lett., 13, 2022
1A92	OLIGOMERIZATION DOMAIN OF HEPATITIS DELTA ANTIGEN Descriptor: DELTA ANTIGEN Authors: Zuccola, H.J, Hogle, J.M. Deposit date: 1998-04-15 Release date: 1999-06-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis of the oligomerization of hepatitis delta antigen. Structure, 6, 1998
3SR4	Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor Descriptor: (2S)-2-azanyl-4-[[(2S,3S,4R,5R)-5-[6-(methylamino)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, ACETATE ION, GLYCEROL, ... Authors: Diao, J, Chen, P, Yao, Y, Prasad, B.V.V, Song, Y. Deposit date: 2011-07-06 Release date: 2011-10-05 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies. J.Am.Chem.Soc., 133, 2011
1WH9	Solution structure of the KH domain of human ribosomal protein S3 Descriptor: 40S ribosomal protein S3 Authors: Nameki, N, Tomizawa, T, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2004-05-28 Release date: 2004-11-28 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: Solution structure of the KH domain of human ribosomal protein S3 To be Published
6LBI	Crystal Structure of FOXO1-DBD homodimer bound to a palindromic DNA sequence Descriptor: Forkhead box protein O1, IRE0 Authors: Li, J, Dai, S.Y, Chen, Y.H. Deposit date: 2019-11-14 Release date: 2021-02-10 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.067 Å) Cite: Mechanism of forkhead transcription factors binding to a novel palindromic DNA site. Nucleic Acids Res., 49, 2021
4IQR	Multi-Domain Organization of the HNF4alpha Nuclear Receptor Complex on DNA Descriptor: DNA (5'-D(*CP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), Hepatocyte nuclear factor 4-alpha, ... Authors: Chandra, V, Huang, P, Kim, Y, Rastinejad, F. Deposit date: 2013-01-13 Release date: 2013-03-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex. Nature, 495, 2013

 

12345>