1L5G
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN AVB3 IN COMPLEX WITH AN ARG-GLY-ASP LIGAND
Descriptor:INTEGRIN ALPHA V, INTEGRIN BETA-3, CYCLIC ARG-GLY-ASP PEPTIDE
Authors:Xiong, J.-P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S.L., Arnaout, M.A.
Deposit date:2002-03-06
Release date:2002-04-17
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.
Science, 296, 2002
1M1X
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+
Descriptor:Integrin alpha-V, Integrin beta-3
Authors:Xiong, J.-P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S.L., Arnaout, M.A.
Deposit date:2002-06-20
Release date:2002-08-14
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.
Science, 296, 2002
1TYE
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STRUCTURAL BASIS FOR ALLOSTERY IN INTEGRINS AND BINDING OF LIGAND-MIMETIC THERAPEUTICS TO THE PLATELET RECEPTOR FOR FIBRINOGEN
Descriptor:Integrin alpha-IIb and beta-3/monoclonal antibody 10E5 light and heavy chains
Authors:Xiao, T., Takagi, J., Coller, B.S., Wang, J.-H., Springer, T.A.
Deposit date:2004-07-07
Release date:2004-10-12
Modification date:2014-09-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
Nature, 432, 2004
1U8C
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A NOVEL ADAPTATION OF THE INTEGRIN PSI DOMAIN REVEALED FROM ITS CRYSTAL STRUCTURE
Descriptor:Integrin alpha-V, Integrin beta-3
Authors:Xiong, J.P., Stehle, T., Goodman, S.L., Arnaout, M.A.
Deposit date:2004-08-05
Release date:2004-12-28
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A novel adaptation of the integrin PSI domain revealed from its crystal structure.
J.Biol.Chem., 279, 2004
2VC2
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST L-739758
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-09-18
Release date:2008-09-02
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDK
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDL
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDM
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST TIROFIBAN
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDN
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST EPTIFIBATIDE
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, EPTIFIBATIDE, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDO
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO FIBRINOGEN GAMMA CHAIN PEPTIDE, HHLGGAKQAGDV
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, GAMMA POLYPEPTIDE, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDP
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO FIBRINOGEN GAMMA CHAIN PEPTIDE,LGGAKQAGDV
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDQ
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO A CHIMERIC FIBRINOGEN GAMMA CHAIN PEPTIDE, HHLGGAKQRGDV
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, GAMMA POLYPEPTIDE, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDR
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO A CHIMERIC FIBRINOGEN GAMMA CHAIN PEPTIDE, LGGAKQRGDV
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
3FCS
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STRUCTURE OF COMPLETE ECTODOMAIN OF INTEGRIN AIIBB3
Descriptor:Integrin, alpha 2b , Integrin beta-3
Authors:Zhu, J., Luo, B.-H., Xiao, T., Zhang, C., Nishida, N., Springer, T.A.
Deposit date:2008-11-22
Release date:2009-01-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
Mol.Cell, 32, 2008
3FCU
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STRUCTURE OF HEADPIECE OF INTEGRIN AIIBB3 IN OPEN CONFORMATION
Descriptor:Integrin, alpha 2b (Platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), Integrin beta-3
Authors:Zhu, J., Luo, B.-H., Xiao, T., Zhang, C., Nishida, N., Springer, T.A.
Deposit date:2008-11-22
Release date:2009-01-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
Mol.Cell, 32, 2008
3IJE
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CRYSTAL STRUCTURE OF THE COMPLETE INTEGRIN ALHAVBETA3 ECTODOMAIN PLUS AN ALPHA/BETA TRANSMEMBRANE FRAGMENT
Descriptor:Integrin alpha-V, Integrin beta-3
Authors:Xiong, J-.P., Mahalingham, B., Rui, X., Hyman, B.T., Goodman, S.L., Arnaout, M.A.
Deposit date:2009-08-04
Release date:2009-09-29
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment.
J.Cell Biol., 186, 2009
3K6S
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STRUCTURE OF INTEGRIN ALPHAXBETA2 ECTODOMAIN
Descriptor:Integrin alpha-X, Integrin beta-2
Authors:Xie, C., Zhu, J., Chen, X., Mi, L., Nishida, N., Springer, T.A.
Deposit date:2009-10-09
Release date:2010-01-12
Modification date:2010-03-02
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of an integrin with an alphaI domain, complement receptor type 4.
Embo J., 29, 2010
3K71
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STRUCTURE OF INTEGRIN ALPHAX BETA2 ECTODOMAIN
Descriptor:Integrin alpha-X, Integrin beta-2
Authors:Xie, C., Zhu, J., Chen, X., Mi, L., Nishida, N., Springer, T.A.
Deposit date:2009-10-11
Release date:2010-01-12
Modification date:2010-03-02
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:Structure of an integrin with an alphaI domain, complement receptor type 4.
Embo J., 29, 2010
3K72
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STRUCTURE OF INTEGRIN ALPHAX BETA2
Descriptor:Integrin alpha-X, Integrin beta-2
Authors:Xie, C., Zhu, J., Chen, X., Mi, L., Nishida, N., Springer, T.A.
Deposit date:2009-10-11
Release date:2010-01-12
Modification date:2010-03-02
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structure of an integrin with an alphaI domain, complement receptor type 4.
Embo J., 29, 2010
3NID
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THE CLOSED HEADPIECE OF INTEGRIN ALPHAIIB BETA3 AND ITS COMPLEX WITH AN ALPAHIIB BETA3 -SPECIFIC ANTAGONIST THAT DOES NOT INDUCE OPENING
Descriptor:Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, Monoclonal antibody 10E5 light chain
Authors:Zhu, J.H., Zhu, J.Q., Springer, T.A.
Deposit date:2010-06-15
Release date:2010-12-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
Blood, 116, 2010
3NIF
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THE CLOSED HEADPIECE OF INTEGRIN IIB 3 AND ITS COMPLEX WITH AN IIB 3 -SPECIFIC ANTAGONIST THAT DOES NOT INDUCE OPENING
Descriptor:Integrin alphaIIB beta3, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, Monoclonal antibody 10E5 light chain
Authors:Zhu, J.H., Zhu, J.Q., Springer, T.A.
Deposit date:2010-06-15
Release date:2010-12-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
Blood, 116, 2010
3NIG
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THE CLOSED HEADPIECE OF INTEGRIN IIB 3 AND ITS COMPLEX WITH AN IIB 3 -SPECIFIC ANTAGONIST THAT DOES NOT INDUCE OPENING
Descriptor:Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, Monoclonal antibody 10E5 light chain
Authors:Zhu, J.H., Zhu, J.Q., Springer, T.A.
Deposit date:2010-06-15
Release date:2010-12-22
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
Blood, 116, 2010
3T3M
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A NOVEL HIGH AFFINITY INTEGRIN ALPHAIIBBETA3 RECEPTOR ANTAGONIST THAT UNEXPECTEDLY DISPLACES MG2+ FROM THE BETA3 MIDAS
Descriptor:Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, Monoclonal antibody 10E5 light chain
Authors:Zhu, J., Zhu, J., Springer, T.A.
Deposit date:2011-07-25
Release date:2012-03-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
Sci Transl Med, 4, 2012
3T3P
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A NOVEL HIGH AFFINITY INTEGRIN ALPHAIIBBETA3 RECEPTOR ANTAGONIST THAT UNEXPECTEDLY DISPLACES MG2+ FROM THE BETA3 MIDAS
Descriptor:Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, Monoclonal antibody 10E5 light chain
Authors:Zhu, J., Zhu, J., Springer, T.A.
Deposit date:2011-07-25
Release date:2012-03-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
Sci Transl Med, 4, 2012
3V4P
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CRYSTAL STRUCTURE OF A4B7 HEADPIECE COMPLEXED WITH FAB ACT-1
Descriptor:Integrin alpha-4, Integrin beta-7, heavy chain, light chain
Authors:Yu, Y., Zhu, J., Springer, T.A.
Deposit date:2011-12-15
Release date:2012-01-11
Modification date:2012-03-28
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural specializations of a4b7, an Integrin that Mediates Rolling Adhesion
J.Cell Biol., 196, 2012
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