2CSX
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CRYSTAL STRUCTURE OF AQUIFEX AEOLICUS METHIONYL-TRNA SYNTHETASE COMPLEXED WITH TRNA(MET)
Descriptor:Methionyl-tRNA synthetase/RNA Complex
Authors:Nakanishi, K., Ogiso, Y., Nakama, T., Fukai, S., Nureki, O., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-23
Release date:2005-09-20
Modification date:2010-01-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for anticodon recognition by methionyl-tRNA synthetase.
Nat.Struct.Mol.Biol., 12, 2005
2CT8
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CRYSTAL STRUCTURE OF AQUIFEX AEOLICUS METHIONYL-TRNA SYNTHETASE COMPLEXED WITH TRNA(MET) AND METHIONYL-ADENYLATE ANOLOGUE
Descriptor:Methionyl-tRNA synthetase/RNA Complex
Authors:Nakanishi, K., Ogiso, Y., Nakama, T., Fukai, S., Nureki, O., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-23
Release date:2005-09-20
Modification date:2010-01-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for anticodon recognition by methionyl-tRNA synthetase.
Nat.Struct.Mol.Biol., 12, 2005
4DLP
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CRYSTAL STRUCTURE OF METHIONYL-TRNA SYNTHETASE METRS FROM BRUCELLA MELITENSIS BOUND TO SELENOMETHIONINE
Descriptor:Aminoacyl-tRNA synthetase, class I:Aminoacyl-tRNA synthetase, class Ia:Methionyl-tRNA synthetase, class Ia (E.C.6.1.1.10)
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-02-06
Release date:2012-02-15
Modification date:2016-08-17
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.
Plos One, 11, 2016
4PY2
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CRYSTAL STRUCTURE OF METHIONYL-TRNA SYNTHETASE METRS FROM BRUCELLA MELITENSIS IN COMPLEX WITH INHIBITOR 1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA
Descriptor:Methionine--tRNA ligase (E.C.6.1.1.10)
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2014-03-25
Release date:2015-04-15
Modification date:2016-08-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.
Plos One, 11, 2016
4QRD
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STRUCTURE OF METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH N-(1H-BENZIMIDAZOL-2-YLMETHYL)-N'-(2,4-DICHLOROPHENYL)-6-(MORPHOLIN-4-YL)-1,3,5-TRIAZINE-2,4-DIAMINE
Descriptor:Methionyl-tRNA synthetase (E.C.6.1.1.10)
Authors:Li, X., Hilgers, M.T., Stidham, M., Brown-Driver, V., Shaw, K.J., Finn, J.
Deposit date:2014-06-30
Release date:2015-07-29
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Discovery and SAR of a Novel Series of Pyrimidine Antibacterials Targeting Methionyl-tRNA Synthetase
to be published
4QRE
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STRUCTURE OF METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH 1-(4-{4-[(1H-BENZIMIDAZOL-2-YLMETHYL)AMINO]-6-(4,5-DIMETHOXY-2-METHYLPHENOXY)PYRIMIDIN-2-YL}PIPERAZIN-1-YL)ETHANONE
Descriptor:Methionyl-tRNA synthetase (E.C.6.1.1.10)
Authors:Hilgers, M.T.
Deposit date:2014-06-30
Release date:2015-07-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery and SAR of a Novel Series of Pyrimidine Antibacterials Targeting Methionyl-tRNA Synthetase
to be published
4XKZ
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CRYSTAL STRUCTURE OF THE C-TERMINAL ANTICODON LOOP BINDING DOMAIN OF A VALYL-TRNA SYNTHETASE FROM PSEUDOMONAS AERUGINOSA
Descriptor:valyl-tRNA synthetase (E.C.6.1.1.9)
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2015-01-12
Release date:2015-02-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the C-terminal anticodon loop binding domain of a valyl-tRNA synthetase from Pseudomonas aeruginosa.
To Be Published
5K0S
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CRYSTAL STRUCTURE OF METHIONYL-TRNA SYNTHETASE METRS FROM BRUCELLA MELITENSIS IN COMPLEX WITH INHIBITOR CHEM 1312
Descriptor:Methionine--tRNA ligase (E.C.6.1.1.10)
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2016-05-17
Release date:2016-05-25
Modification date:2016-08-17
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.
Plos One, 11, 2016
5K0T
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CRYSTAL STRUCTURE OF METHIONYL-TRNA SYNTHETASE METRS FROM BRUCELLA MELITENSIS IN COMPLEX WITH INHIBITOR CHEM 1415
Descriptor:Methionine--tRNA ligase (E.C.6.1.1.10)
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2016-05-17
Release date:2016-05-25
Modification date:2016-08-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.
Plos One, 11, 2016
1FFY
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INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN
Descriptor:ISOLEUCYL-TRNA SYNTHETASE (E.C.6.1.1.5)/TRNA COMPLEX
Authors:Silvian, L.F., Wang, J., Steitz, T.A.
Deposit date:2000-07-26
Release date:2000-08-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin.
Science, 285, 1999
1GAX
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS VALYL-TRNA SYNTHETASE COMPLEXED WITH TRNA(VAL) AND VALYL-ADENYLATE ANALOGUE
Descriptor:VALYL-TRNA SYNTHETASE (E.C.6.1.1.9)/RNA COMPLEX
Authors:Fukai, S., Nureki, O., Sekine, S., Shimada, A., Tao, J., Vassylyev, D.G., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2000-06-23
Release date:2000-12-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for double-sieve discrimination of L-valine from L-isoleucine and L-threonine by the complex of tRNA(Val) and valyl-tRNA synthetase.
Cell(Cambridge,Mass.), 103, 2000
1H3N
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LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A SULPHAMOYL ANALOGUE OF LEUCYL-ADENYLATE
Descriptor:LEUCYL-TRNA SYNTHETASE (E.C.6.1.1.4)
Authors:Cusack, S., Yaremchuk, A., Tukalo, M.
Deposit date:2002-09-11
Release date:2002-09-27
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2A Structure of Leucyl-tRNA Synthetase and its Complex with a Leucyl-Adenylate Analogue
Embo J., 19, 2000
1ILE
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ISOLEUCYL-TRNA SYNTHETASE
Descriptor:ISOLEUCYL-TRNA SYNTHETASE
Authors:Nureki, O., Vassylyev, D.G., Tateno, M., Shimada, A., Nakama, T., Fukai, S., Konno, M., Schimmel, P., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:1998-02-24
Release date:1999-04-13
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Enzyme structure with two catalytic sites for double-sieve selection of substrate.
Science, 280, 1998
1IVS
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS VALYL-TRNA SYNTHETASE COMPLEXED WITH TRNA(VAL) AND VALYL-ADENYLATE ANALOGUE
Descriptor:Valyl-tRNA synthetase (E.C.6.1.1.9)/TRNA (VAL) Complex
Authors:Fukai, S., Nureki, O., Sekine, S.-I., Shimada, A., Vassylyev, D.G., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-03-29
Release date:2003-02-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Mechanism of molecular interactions for tRNA(Val) recognition by valyl-tRNA synthetase
RNA, 9, 2003
1IYW
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PRELIMINARY STRUCTURE OF THERMUS THERMOPHILUS LIGAND-FREE VALYL-TRNA SYNTHETASE
Descriptor:Valyl-tRNA Synthetase(E.C.6.1.1.9)
Authors:Fukai, S., Nureki, O., Sekine, S., Shimada, A., Vassylyev, D.G., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-09-10
Release date:2003-06-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (4 Å)
Cite:Mechanism of molecular interactions for tRNA(Val) recognition by valyl-tRNA synthetase
RNA, 9, 2003
1JZQ
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ISOLEUCYL-TRNA SYNTHETASE COMPLEXED WITH ISOLEUCYL-ADENYLATE ANALOGUE
Descriptor:Isoleucyl-tRNA synthetase(E.C.6.1.1.5)/ N-[ISOLEUCINYL]-N'-[ADENOSYL]-DIAMINOSUFONE
Authors:Nakama, T., Nureki, O., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2001-09-17
Release date:2001-12-21
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase.
J.Biol.Chem., 276, 2001
1JZS
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ISOLEUCYL-TRNA SYNTHETASE COMPLEXED WITH MUPIROCIN
Descriptor:Isoleucyl-tRNA synthetase(E.C.6.1.1.5)/ MUPIROCIN
Authors:Nakama, T., Nureki, O., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2001-09-17
Release date:2001-12-21
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase.
J.Biol.Chem., 276, 2001
1OBC
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LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A POST-TRANSFER EDITING SUBSTRATE ANALOGUE
Descriptor:LEUCYL-TRNA SYNTHETASE
Authors:Cusack, S., Yaremchuk, A., Tukalo, M.
Deposit date:2003-01-30
Release date:2003-05-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase
Mol.Cell, 11, 2003
1OBH
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LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A PRE-TRANSFER EDITING SUBSTRATE ANALOGUE IN BOTH SYNTHETIC ACTIVE SITE AND EDITING SITE
Descriptor:LEUCYL-TRNA SYNTHETASE
Authors:Cusack, S., Yaremchuk, A., Tukalo, M.
Deposit date:2003-01-31
Release date:2003-05-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase
Mol.Cell, 11, 2003
1QU2
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INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN
Descriptor:ISOLEUCYL-TRNA SYNTHETASE (E.C.6.1.1.5)/TRNA COMPLEX
Authors:Silvian, L.F., Wang, J., Steitz, T.A.
Deposit date:1999-07-06
Release date:1999-08-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin.
Science, 285, 1999
1QU3
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INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN
Descriptor:ISOLEUCYL-TRNA SYNTHETASE (E.C.6.1.1.5)/TRNA COMPLEX
Authors:Silvian, L.F., Wang, J., Steitz, T.A.
Deposit date:1999-07-06
Release date:1999-08-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin.
Science, 285, 1999
1RQG
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METHIONYL-TRNA SYNTHETASE FROM PYROCOCCUS ABYSSI
Descriptor:Methionyl-tRNA synthetase (E.C.6.1.1.10)
Authors:Crepin, T., Schmitt, E., Blanquet, S., Mechulam, Y.
Deposit date:2003-12-05
Release date:2004-05-25
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Three-dimensional structure of methionyl-tRNA synthetase from Pyrococcus abyssi.
Biochemistry, 43, 2004
1WKB
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CRYSTAL STRUCTURE OF LEUCYL-TRNA SYNTHETASE FROM THE ARCHAEON PYROCOCCUS HORIKOSHII REVEALS A NOVEL EDITING DOMAIN ORIENTATION
Descriptor:Leucyl-tRNA synthetase (E.C.6.1.1.4)
Authors:Fukunaga, R., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-05-30
Release date:2005-02-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of Leucyl-tRNA Synthetase from the Archaeon Pyrococcus horikoshii Reveals a Novel Editing Domain Orientation
J.Mol.Biol., 346, 2005
1WZ2
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THE CRYSTAL STRUCTURE OF LEUCYL-TRNA SYNTHETASE AND TRNA(LEUCINE) COMPLEX
Descriptor:Leucyl-tRNA synthetase(E.C.6.1.1.4), tRNA
Authors:Fukunaga, R., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-02-21
Release date:2005-09-06
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:The crystal structure of Leucyl-tRNA synthetase and tRNA(leucine) complex
to be published
2BTE
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THERMUS THERMOPHILUS LEUCYL-TRNA SYNTHETASE COMPLEXED WITH WITH A TRNALEU TRANSCRIPT IN THE POST-EDITING CONFORMATION AND A POST-TRANSFER EDITING SUBSTRATE ANALOGUE
Descriptor:AMINOACYL-TRNA SYNTHETASE (E.C.6.1.1.4)
Authors:Cusack, S., Tukalo, M., Yaremchuk, A., Fukunaga, R., Yokoyama, S.
Deposit date:2005-05-31
Release date:2005-09-15
Modification date:2011-03-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer- Editing Conformation.
Nat.Struct.Mol.Biol., 12, 2005
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