2CSX
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CRYSTAL STRUCTURE OF AQUIFEX AEOLICUS METHIONYL-TRNA SYNTHETASE COMPLEXED WITH TRNA(MET)
Descriptor:Methionyl-tRNA synthetase/RNA Complex
Authors:Nakanishi, K., Ogiso, Y., Nakama, T., Fukai, S., Nureki, O., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-23
Release date:2005-09-20
Modification date:2010-01-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for anticodon recognition by methionyl-tRNA synthetase.
Nat.Struct.Mol.Biol., 12, 2005
2CT8
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CRYSTAL STRUCTURE OF AQUIFEX AEOLICUS METHIONYL-TRNA SYNTHETASE COMPLEXED WITH TRNA(MET) AND METHIONYL-ADENYLATE ANOLOGUE
Descriptor:Methionyl-tRNA synthetase/RNA Complex
Authors:Nakanishi, K., Ogiso, Y., Nakama, T., Fukai, S., Nureki, O., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-23
Release date:2005-09-20
Modification date:2010-01-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for anticodon recognition by methionyl-tRNA synthetase.
Nat.Struct.Mol.Biol., 12, 2005
4DLP
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CRYSTAL STRUCTURE OF METHIONYL-TRNA SYNTHETASE METRS FROM BRUCELLA MELITENSIS BOUND TO SELENOMETHIONINE
Descriptor:Aminoacyl-tRNA synthetase, class I:Aminoacyl-tRNA synthetase, class Ia:Methionyl-tRNA synthetase, class Ia (E.C.6.1.1.10)
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-02-06
Release date:2012-02-15
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Ligand-induced co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms
To be Published
4LNE
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CRYSTAL STRUCTURE OF METRS IN COMPLEX WITH 2-({3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}AMINO)QUINOLIN-4(1H)-ONE
Descriptor:Methionine-tRNA ligase (E.C.6.1.1.10)
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2013-07-11
Release date:2013-08-07
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of MetRS in complex with 2-({3-[(3,5-dichlorobenzyl)amino]propyl}amino)quinolin-4(1H)-one
To be Published
4PPW
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CRYSTAL STRUCTURE OF METHIONYL-TRNA SYNTHETASE METRS FROM BRUCELLA MELITENSIS IN COMPLEX WITH INHIBITOR CHEM 1415
Descriptor:Methionine--tRNA ligase (E.C.6.1.1.10)
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2014-02-27
Release date:2014-03-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor Chem 1415
To be Published
4PY2
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CRYSTAL STRUCTURE OF METHIONYL-TRNA SYNTHETASE METRS FROM BRUCELLA MELITENSIS IN COMPLEX WITH INHIBITOR 1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA
Descriptor:Methionine--tRNA ligase (E.C.6.1.1.10)
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2014-03-25
Release date:2015-04-15
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor Chem 1433
To be Published
4XKZ
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CRYSTAL STRUCTURE OF THE C-TERMINAL ANTICODON LOOP BINDING DOMAIN OF A VALYL-TRNA SYNTHETASE FROM PSEUDOMONAS AERUGINOSA
Descriptor:valyl-tRNA synthetase (E.C.6.1.1.9)
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2015-01-12
Release date:2015-02-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the C-terminal anticodon loop binding domain of a valyl-tRNA synthetase from Pseudomonas aeruginosa.
To Be Published
1ILE
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ISOLEUCYL-TRNA SYNTHETASE
Descriptor:ISOLEUCYL-TRNA SYNTHETASE
Authors:Nureki, O., Vassylyev, D.G., Tateno, M., Shimada, A., Nakama, T., Fukai, S., Konno, M., Schimmel, P., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:1998-02-24
Release date:1999-04-13
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Enzyme structure with two catalytic sites for double-sieve selection of substrate.
Science, 280, 1998
1JZQ
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ISOLEUCYL-TRNA SYNTHETASE COMPLEXED WITH ISOLEUCYL-ADENYLATE ANALOGUE
Descriptor:Isoleucyl-tRNA synthetase(E.C.6.1.1.5)/ N-[ISOLEUCINYL]-N'-[ADENOSYL]-DIAMINOSUFONE
Authors:Nakama, T., Nureki, O., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2001-09-17
Release date:2001-12-21
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase.
J.Biol.Chem., 276, 2001
1JZS
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ISOLEUCYL-TRNA SYNTHETASE COMPLEXED WITH MUPIROCIN
Descriptor:Isoleucyl-tRNA synthetase(E.C.6.1.1.5)/ MUPIROCIN
Authors:Nakama, T., Nureki, O., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2001-09-17
Release date:2001-12-21
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase.
J.Biol.Chem., 276, 2001
3ZGZ
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TERNARY COMPLEX OF E. COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND TOXIC MOIETY FROM AGROCIN 84 (TM84) IN AMINOACYLATION-LIKE CONFORMATION
Descriptor:LEUCINE--TRNA LIGASE (E.C.6.1.1.4)
Authors:Chopra, S., Palencia, A., Virus, C., Tripathy, A., Temple, B.R., Velazquez-Campoy, A., Cusack, S., Reader, J.S.
Deposit date:2012-12-19
Release date:2013-01-30
Modification date:2013-02-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Plant Tumour Biocontrol Agent Employs a tRNA-Dependent Mechanism to Inhibit Leucyl-tRNA Synthetase
Nat.Commun., 4, 2013
3ZIU
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CRYSTAL STRUCTURE OF MYCOPLASMA MOBILE LEUCYL-TRNA SYNTHETASE WITH LEU-AMS IN THE ACTIVE SITE
Descriptor:LEUCYL-TRNA SYNTHETASE (E.C.6.1.1.4)
Authors:Li, L., Palencia, A., Lukk, T., Li, Z., Luthey-Schulten, Z.A., Cusack, S., Martinis, S.A., Boniecki, M.T.
Deposit date:2013-01-10
Release date:2013-02-27
Modification date:2013-03-20
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Leucyl-tRNA Synthetase Editing Domain Functions as a Molecular Rheostat to Control Codon Ambiguity in Mycoplasma Pathogens.
Proc.Natl.Acad.Sci.USA, 110, 2013
3ZJT
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3017 IN THE EDITING CONFORMATION
Descriptor:LEUCYL-TRNA SYNTHETASE (E.C.6.1.1.4)
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJU
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3016 IN THE EDITING CONFORMATION
Descriptor:LEUCYL-TRNA SYNTHETASE (E.C.6.1.1.4)
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJV
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3213 IN THE EDITING CONFORMATION
Descriptor:LEUCINE--TRNA LIGASE (E.C.6.1.1.4)
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
4AQ7
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TERNARY COMPLEX OF E. COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND LEUCYL-ADENYLATE ANALOGUE IN THE AMINOACYLATION CONFORMATION
Descriptor:LEUCINE--TRNA LIGASE (E.C.6.1.1.4)
Authors:Palencia, A., Crepin, T., Vu, M.T., Lincecum Jr, T.L., Martinis, S.A., Cusack, S.
Deposit date:2012-04-13
Release date:2012-06-13
Modification date:2012-10-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Dynamics of the Aminoacylation and Proofreading Functional Cycle of Bacterial Leucyl-tRNA Synthetase
Nat.Struct.Mol.Biol., 19, 2012
4ARC
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TERNARY COMPLEX OF E. COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND LEUCINE IN THE EDITING CONFORMATION
Descriptor:LEUCINE--TRNA LIGASE (E.C.6.1.1.4)
Authors:Palencia, A., Crepin, T., Vu, M.T., Lincecum Jr, T.L., Martinis, S.A., Cusack, S.
Deposit date:2012-04-23
Release date:2012-06-13
Modification date:2012-07-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Dynamics of the Aminoacylation and Proofreading Functional Cycle of Bacterial Leucyl-tRNA Synthetase
Nat.Struct.Mol.Biol., 19, 2012
4ARI
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TERNARY COMPLEX OF E. COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN2679 IN THE EDITING CONFORMATION
Descriptor:LEUCINE--TRNA LIGASE (E.C.6.1.1.4)
Authors:Palencia, A., Crepin, T., Vu, M.T., Lincecum Jr, T.L., Martinis, S.A., Cusack, S.
Deposit date:2012-04-24
Release date:2012-06-13
Modification date:2012-07-25
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural Dynamics of the Aminoacylation and Proofreading Functional Cycle of Bacterial Leucyl-tRNA Synthetase
Nat.Struct.Mol.Biol., 19, 2012
4AS1
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TERNARY COMPLEX OF E. COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN2679 IN THE EDITING CONFORMATION
Descriptor:LEUCINE--TRNA LIGASE (E.C.6.1.1.4)
Authors:Palencia, A., Crepin, T., Vu, M.T., Lincecum Jr, T.L., Martinis, S.A., Cusack, S.
Deposit date:2012-04-27
Release date:2012-06-13
Modification date:2012-07-25
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural Dynamics of the Aminoacylation and Proofreading Functional Cycle of Bacterial Leucyl-tRNA Synthetase
Nat.Struct.Mol.Biol., 19, 2012
4CQN
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CRYSTAL STRUCTURE OF THE E.COLI LEURS-TRNA COMPLEX WITH THE NON- COGNATE ISOLEUCYL ADENYLATE ANALOGUE
Descriptor:LEUCINE--TRNA LIGASE (E.C.6.1.1.4)
Authors:Palencia, A., Cusack, S., Cvetesic, N., Haslaz, I., Gruic-Sovulj, I.
Deposit date:2014-02-20
Release date:2014-07-02
Modification date:2014-08-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Physiological Target for Leurs Translational Quality Control is Norvaline
Embo J., 33, 2014
5AH5
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CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF AGROBACTERIUM RADIOBACTER K84 AGNB2 LEURS-TRNA-LEUAMS
Descriptor:LEUCINE--TRNA LIGASE (E.C.6.1.1.4)
Authors:Palencia, A., Chopra, S., Virus, C., Schulwitz, S., Temple, B.R., Cusack, S., Reader, J.S.
Deposit date:2015-02-05
Release date:2016-02-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Antibiotic Self-Defence Mechanism Allows Plant Tumor Biocontrol Agent to Aminoacylate tRNA
To be Published
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