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1FFY
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1ffy
INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN
Descriptor:ISOLEUCYL-TRNA SYNTHETASE (E.C.6.1.1.5)/TRNA COMPLEX
Authors:Silvian, L.F., Wang, J., Steitz, T.A.
Deposit date:2000-07-26
Release date:2000-08-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin.
Science, 285, 1999
1GAX
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1gax
CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS VALYL-TRNA SYNTHETASE COMPLEXED WITH TRNA(VAL) AND VALYL-ADENYLATE ANALOGUE
Descriptor:VALYL-TRNA SYNTHETASE (E.C.6.1.1.9)/RNA COMPLEX
Authors:Fukai, S., Nureki, O., Sekine, S., Shimada, A., Tao, J., Vassylyev, D.G., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2000-06-23
Release date:2000-12-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for double-sieve discrimination of L-valine from L-isoleucine and L-threonine by the complex of tRNA(Val) and valyl-tRNA synthetase.
Cell(Cambridge,Mass.), 103, 2000
1H3N
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1h3n
LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A SULPHAMOYL ANALOGUE OF LEUCYL-ADENYLATE
Descriptor:LEUCYL-TRNA SYNTHETASE (E.C.6.1.1.4)
Authors:Cusack, S., Yaremchuk, A., Tukalo, M.
Deposit date:2002-09-11
Release date:2002-09-27
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2A Structure of Leucyl-tRNA Synthetase and its Complex with a Leucyl-Adenylate Analogue
Embo J., 19, 2000
1ILE
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1ile
ISOLEUCYL-TRNA SYNTHETASE
Descriptor:ISOLEUCYL-TRNA SYNTHETASE
Authors:Nureki, O., Vassylyev, D.G., Tateno, M., Shimada, A., Nakama, T., Fukai, S., Konno, M., Schimmel, P., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:1998-02-24
Release date:1999-04-13
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Enzyme structure with two catalytic sites for double-sieve selection of substrate.
Science, 280, 1998
1IVS
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1ivs
CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS VALYL-TRNA SYNTHETASE COMPLEXED WITH TRNA(VAL) AND VALYL-ADENYLATE ANALOGUE
Descriptor:Valyl-tRNA synthetase (E.C.6.1.1.9)/TRNA (VAL) Complex
Authors:Fukai, S., Nureki, O., Sekine, S.-I., Shimada, A., Vassylyev, D.G., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-03-29
Release date:2003-02-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Mechanism of molecular interactions for tRNA(Val) recognition by valyl-tRNA synthetase
RNA, 9, 2003
1IYW
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1iyw
PRELIMINARY STRUCTURE OF THERMUS THERMOPHILUS LIGAND-FREE VALYL-TRNA SYNTHETASE
Descriptor:Valyl-tRNA Synthetase(E.C.6.1.1.9)
Authors:Fukai, S., Nureki, O., Sekine, S., Shimada, A., Vassylyev, D.G., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-09-10
Release date:2003-06-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (4 Å)
Cite:Mechanism of molecular interactions for tRNA(Val) recognition by valyl-tRNA synthetase
RNA, 9, 2003
1JZQ
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1jzq
ISOLEUCYL-TRNA SYNTHETASE COMPLEXED WITH ISOLEUCYL-ADENYLATE ANALOGUE
Descriptor:Isoleucyl-tRNA synthetase(E.C.6.1.1.5)/ N-[ISOLEUCINYL]-N'-[ADENOSYL]-DIAMINOSUFONE
Authors:Nakama, T., Nureki, O., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2001-09-17
Release date:2001-12-21
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase.
J.Biol.Chem., 276, 2001
1JZS
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1jzs
ISOLEUCYL-TRNA SYNTHETASE COMPLEXED WITH MUPIROCIN
Descriptor:Isoleucyl-tRNA synthetase(E.C.6.1.1.5)/ MUPIROCIN
Authors:Nakama, T., Nureki, O., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2001-09-17
Release date:2001-12-21
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase.
J.Biol.Chem., 276, 2001
1OBC
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1obc
LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A POST-TRANSFER EDITING SUBSTRATE ANALOGUE
Descriptor:LEUCYL-TRNA SYNTHETASE
Authors:Cusack, S., Yaremchuk, A., Tukalo, M.
Deposit date:2003-01-30
Release date:2003-05-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase
Mol.Cell, 11, 2003
1OBH
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1obh
LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A PRE-TRANSFER EDITING SUBSTRATE ANALOGUE IN BOTH SYNTHETIC ACTIVE SITE AND EDITING SITE
Descriptor:LEUCYL-TRNA SYNTHETASE
Authors:Cusack, S., Yaremchuk, A., Tukalo, M.
Deposit date:2003-01-31
Release date:2003-05-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase
Mol.Cell, 11, 2003
1QU2
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1qu2
INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN
Descriptor:ISOLEUCYL-TRNA SYNTHETASE (E.C.6.1.1.5)/TRNA COMPLEX
Authors:Silvian, L.F., Wang, J., Steitz, T.A.
Deposit date:1999-07-06
Release date:1999-08-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin.
Science, 285, 1999
1QU3
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1qu3
INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN
Descriptor:ISOLEUCYL-TRNA SYNTHETASE (E.C.6.1.1.5)/TRNA COMPLEX
Authors:Silvian, L.F., Wang, J., Steitz, T.A.
Deposit date:1999-07-06
Release date:1999-08-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin.
Science, 285, 1999
1RQG
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1rqg
METHIONYL-TRNA SYNTHETASE FROM PYROCOCCUS ABYSSI
Descriptor:Methionyl-tRNA synthetase (E.C.6.1.1.10)
Authors:Crepin, T., Schmitt, E., Blanquet, S., Mechulam, Y.
Deposit date:2003-12-05
Release date:2004-05-25
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Three-dimensional structure of methionyl-tRNA synthetase from Pyrococcus abyssi.
Biochemistry, 43, 2004
1WKB
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1wkb
CRYSTAL STRUCTURE OF LEUCYL-TRNA SYNTHETASE FROM THE ARCHAEON PYROCOCCUS HORIKOSHII REVEALS A NOVEL EDITING DOMAIN ORIENTATION
Descriptor:Leucyl-tRNA synthetase (E.C.6.1.1.4)
Authors:Fukunaga, R., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-05-30
Release date:2005-02-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of Leucyl-tRNA Synthetase from the Archaeon Pyrococcus horikoshii Reveals a Novel Editing Domain Orientation
J.Mol.Biol., 346, 2005
1WZ2
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1wz2
THE CRYSTAL STRUCTURE OF LEUCYL-TRNA SYNTHETASE AND TRNA(LEUCINE) COMPLEX
Descriptor:Leucyl-tRNA synthetase(E.C.6.1.1.4), tRNA
Authors:Fukunaga, R., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-02-21
Release date:2005-09-06
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:The crystal structure of Leucyl-tRNA synthetase and tRNA(leucine) complex
to be published
2BTE
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2bte
THERMUS THERMOPHILUS LEUCYL-TRNA SYNTHETASE COMPLEXED WITH WITH A TRNALEU TRANSCRIPT IN THE POST-EDITING CONFORMATION AND A POST-TRANSFER EDITING SUBSTRATE ANALOGUE
Descriptor:AMINOACYL-TRNA SYNTHETASE (E.C.6.1.1.4)
Authors:Cusack, S., Tukalo, M., Yaremchuk, A., Fukunaga, R., Yokoyama, S.
Deposit date:2005-05-31
Release date:2005-09-15
Modification date:2011-03-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer- Editing Conformation.
Nat.Struct.Mol.Biol., 12, 2005
2BYT
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2byt
THERMUS THERMOPHILUS LEUCYL-TRNA SYNTHETASE COMPLEXED WITH A TRNALEU TRANSCRIPT IN THE POST-EDITING CONFORMATION
Descriptor:LEUCYL-TRNA SYNTHETASE
Authors:Cusack, S., Tukalo, M., Yaremchuk, A., Fukunaga, R., Yokoyama, S.
Deposit date:2005-08-04
Release date:2005-09-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer-Editing Conformation.
Nat.Struct.Mol.Biol., 12, 2005
2CSX
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2csx
CRYSTAL STRUCTURE OF AQUIFEX AEOLICUS METHIONYL-TRNA SYNTHETASE COMPLEXED WITH TRNA(MET)
Descriptor:Methionyl-tRNA synthetase/RNA Complex
Authors:Nakanishi, K., Ogiso, Y., Nakama, T., Fukai, S., Nureki, O., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-23
Release date:2005-09-20
Modification date:2010-01-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for anticodon recognition by methionyl-tRNA synthetase.
Nat.Struct.Mol.Biol., 12, 2005
2CT8
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2ct8
CRYSTAL STRUCTURE OF AQUIFEX AEOLICUS METHIONYL-TRNA SYNTHETASE COMPLEXED WITH TRNA(MET) AND METHIONYL-ADENYLATE ANOLOGUE
Descriptor:Methionyl-tRNA synthetase/RNA Complex
Authors:Nakanishi, K., Ogiso, Y., Nakama, T., Fukai, S., Nureki, O., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-23
Release date:2005-09-20
Modification date:2010-01-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for anticodon recognition by methionyl-tRNA synthetase.
Nat.Struct.Mol.Biol., 12, 2005
2V0C
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2v0c
LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A SULPHAMOYL ANALOGUE OF LEUCYL-ADENYLATE IN THE SYNTHETIC SITE AND AN ADDUCT OF AMP WITH 5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE (AN2690) IN THE EDITING SITE
Descriptor:AMINOACYL-TRNA SYNTHETASE
Authors:Rock, F., Mao, W., Yaremchuk, A., Tukalo, M., Crepin, T., Zhou, H., Zhang, Y., Hernandez, V., Akama, T., Baker, S., Plattner, J., Shapiro, L., Martinis, S.A., Benkovic, S.J., Cusack, S., Alley, M.R.K.
Deposit date:2007-05-14
Release date:2007-07-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site.
Science, 316, 2007
2V0G
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2v0g
LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A TRNA(LEU) TRANSCRIPT WITH 5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE (AN2690) FORMING AN ADDUCT TO THE RIBOSE OF ADENOSINE-76 IN THE ENZYME EDITING SITE.
Descriptor:AMINOACYL-TRNA SYNTHETASE
Authors:Rock, F., Mao, W., Yaremchuk, A., Tukalo, M., Crepin, T., Zhou, H., Zhang, Y., Hernandez, V., Akama, T., Baker, S., Plattner, J., Shapiro, L., Martinis, S.A., Benkovic, S.J., Cusack, S., Alley, M.R.K.
Deposit date:2007-05-14
Release date:2007-07-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site.
Science, 316, 2007
3ZGZ
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3zgz
TERNARY COMPLEX OF E. COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND TOXIC MOIETY FROM AGROCIN 84 (TM84) IN AMINOACYLATION-LIKE CONFORMATION
Descriptor:LEUCINE--TRNA LIGASE (E.C.6.1.1.4)
Authors:Chopra, S., Palencia, A., Virus, C., Tripathy, A., Temple, B.R., Velazquez-Campoy, A., Cusack, S., Reader, J.S.
Deposit date:2012-12-19
Release date:2013-01-30
Modification date:2013-02-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Plant Tumour Biocontrol Agent Employs a tRNA-Dependent Mechanism to Inhibit Leucyl-tRNA Synthetase
Nat.Commun., 4, 2013
3ZIU
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3ziu
CRYSTAL STRUCTURE OF MYCOPLASMA MOBILE LEUCYL-TRNA SYNTHETASE WITH LEU-AMS IN THE ACTIVE SITE
Descriptor:LEUCYL-TRNA SYNTHETASE (E.C.6.1.1.4)
Authors:Li, L., Palencia, A., Lukk, T., Li, Z., Luthey-Schulten, Z.A., Cusack, S., Martinis, S.A., Boniecki, M.T.
Deposit date:2013-01-10
Release date:2013-02-27
Modification date:2013-03-20
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Leucyl-tRNA Synthetase Editing Domain Functions as a Molecular Rheostat to Control Codon Ambiguity in Mycoplasma Pathogens.
Proc.Natl.Acad.Sci.USA, 110, 2013
3ZJT
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3zjt
TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3017 IN THE EDITING CONFORMATION
Descriptor:LEUCYL-TRNA SYNTHETASE (E.C.6.1.1.4)
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJU
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3zju
TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3016 IN THE EDITING CONFORMATION
Descriptor:LEUCYL-TRNA SYNTHETASE (E.C.6.1.1.4)
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
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