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8THN
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KcsA M96V mutant with Y78ester in High K+
Descriptor: KcsA Fab Heavy Chain, KcsA Fab Light Chain, POTASSIUM ION, ...
Authors:Reddi, R, Valiyaveetil, F.I.
Deposit date:2023-07-17
Release date:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A facile approach for incorporating tyrosine esters to probe ion-binding sites and backbone hydrogen bonds.
J.Biol.Chem., 300, 2023
1BL8
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BU of 1bl8 by Molmil
POTASSIUM CHANNEL (KCSA) FROM STREPTOMYCES LIVIDANS
Descriptor: POTASSIUM ION, PROTEIN (POTASSIUM CHANNEL PROTEIN)
Authors:Doyle, D.A, Cabral, J.M, Pfuetzner, R.A, Kuo, A, Gulbis, J.M, Cohen, S.L, Chait, B.T, Mackinnon, R.
Deposit date:1998-07-23
Release date:1998-07-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The structure of the potassium channel: molecular basis of K+ conduction and selectivity.
Science, 280, 1998
8A35
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BU of 8a35 by Molmil
NaK C-DI mutant with Rb+ and Na+
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Potassium channel protein, RUBIDIUM ION, ...
Authors:Minniberger, S, Plested, A.J.R.
Deposit date:2022-06-07
Release date:2023-02-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors.
J.Mol.Biol., 435, 2023
4BW5
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BU of 4bw5 by Molmil
Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1)
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CADMIUM ION, POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, ...
Authors:Pike, A.C.W, Dong, Y.Y, Dong, L, Quigley, A, Shrestha, L, Mukhopadhyay, S, Strain-Damerell, C, Goubin, S, Grieben, M, Shintre, C.A, Mackenzie, A, Vollmar, M, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N, Carpenter, E.P.
Deposit date:2013-06-30
Release date:2013-07-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:K2P Channel Gating Mechanisms Revealed by Structures of Trek-2 and a Complex with Prozac
Science, 347, 2015
1F6G
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BU of 1f6g by Molmil
POTASSIUM CHANNEL (KCSA) FULL-LENGTH FOLD
Descriptor: VOLTAGE-GATED POTASSIUM CHANNEL
Authors:Cortes, D.M, Perozo, E.
Deposit date:2000-06-21
Release date:2001-02-21
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:Molecular architecture of full-length KcsA: role of cytoplasmic domains in ion permeation and activation gating.
J.Gen.Physiol., 117, 2001
5J9P
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BU of 5j9p by Molmil
KcsA in vitro
Descriptor: Fab, POTASSIUM ION, pH-gated potassium channel KcsA
Authors:Matulef, K, Valiyaveetil, F.I.
Deposit date:2016-04-10
Release date:2016-07-20
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Combining in Vitro Folding with Cell Free Protein Synthesis for Membrane Protein Expression.
Biochemistry, 55, 2016
8DE8
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BU of 8de8 by Molmil
Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM/POPA mixed micelles
Descriptor: (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, POTASSIUM ION, Potassium channel, ...
Authors:Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M.
Deposit date:2022-06-20
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.
Nat Commun, 14, 2023
8DE7
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BU of 8de7 by Molmil
Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM detergent
Descriptor: DODECYL-BETA-D-MALTOSIDE, POTASSIUM ION, Potassium channel, ...
Authors:Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M.
Deposit date:2022-06-20
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.
Nat Commun, 14, 2023
8DE9
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BU of 8de9 by Molmil
Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM/POPE mixed micelles
Descriptor: (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, POTASSIUM ION, Potassium channel, ...
Authors:Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M.
Deposit date:2022-06-20
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.
Nat Commun, 14, 2023
4UUJ
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BU of 4uuj by Molmil
POTASSIUM CHANNEL KCSA-FAB WITH TETRAHEXYLAMMONIUM
Descriptor: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, COBALT (II) ION, ...
Authors:Lenaeus, M.J, Burdette, D, Wagner, T, Focia, P.J, Gross, A.
Deposit date:2014-07-29
Release date:2014-08-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of Kcsa in Complex with Symmetrical Quaternary Ammonium Compounds Reveal a Hydrophobic Binding Site.
Biochemistry, 53, 2014
6PA0
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BU of 6pa0 by Molmil
Structure of the G77A mutant in Sodium Chloride
Descriptor: Antibody HEAVY fragment, Antibody LIGHT fragment, DIACYL GLYCEROL, ...
Authors:Cuello, L.G, Guan, L.
Deposit date:2019-06-11
Release date:2019-08-07
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration.
Proc.Natl.Acad.Sci.USA, 116, 2019
4WFG
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BU of 4wfg by Molmil
Human TRAAK K+ channel in a Tl+ bound conductive conformation
Descriptor: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
Authors:Brohawn, S.G, MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
4WFH
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BU of 4wfh by Molmil
Human TRAAK K+ channel in a Tl+ bound nonconductive conformation
Descriptor: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
Authors:Brohawn, S.G, MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
4WFE
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BU of 4wfe by Molmil
Human TRAAK K+ channel in a K+ bound conductive conformation
Descriptor: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
Authors:Brohawn, S.G, MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
6PIS
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BU of 6pis by Molmil
Mouse two pore domain K+ channel TRAAK (K2P4.1) - Fab complex structure
Descriptor: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, POTASSIUM ION, ...
Authors:Brohawn, S.G.
Deposit date:2019-06-27
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier.
Elife, 8, 2019
4WFF
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BU of 4wff by Molmil
Human TRAAK K+ channel in a K+ bound nonconductive conformation
Descriptor: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
Authors:Brohawn, S.G, MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
6RV3
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BU of 6rv3 by Molmil
Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 1000493
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, DECYL-BETA-D-MALTOPYRANOSIDE, ...
Authors:Rodstrom, K.E.J, Pike, A.C.W, Zhang, W, Quigley, A, Speedman, D, Mukhopadhyay, S.M.M, Shrestha, L, Chalk, R, Venkaya, S, Bushell, S.R, Tessitore, A, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2019-05-30
Release date:2019-08-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A lower X-gate in TASK channels traps inhibitors within the vestibule.
Nature, 582, 2020
5VKH
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BU of 5vkh by Molmil
Closed conformation of KcsA Y82A-F103A mutant
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ...
Authors:Cuello, L.G, Perozo, E, Cortes, D.M.
Deposit date:2017-04-21
Release date:2017-12-06
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The gating cycle of a K+ channel at atomic resolution.
Elife, 6, 2017
6RV4
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BU of 6rv4 by Molmil
Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 2341237
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, POTASSIUM ION, ...
Authors:Rodstrom, K.E.J, Pike, A.C.W, Zhang, W, Quigley, A, Speedman, D, Mukhopadhyay, S.M.M, Shrestha, L, Chalk, R, Venkaya, S, Bushell, S.R, Tessitore, A, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2019-05-30
Release date:2019-08-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A lower X-gate in TASK channels traps inhibitors within the vestibule.
Nature, 582, 2020
5VK6
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BU of 5vk6 by Molmil
Open conformation of KcsA non-inactivating E71A mutant
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ...
Authors:Cuello, L.G, Perozo, E.
Deposit date:2017-04-21
Release date:2017-12-06
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The gating cycle of a K+ channel at atomic resolution.
Elife, 6, 2017
5VKE
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BU of 5vke by Molmil
Open conformation of KcsA deep-inactivated
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ...
Authors:Cuello, L.G, Perozo, E, Cortes, D.M.
Deposit date:2017-04-21
Release date:2017-12-06
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:The gating cycle of a K+ channel at atomic resolution.
Elife, 6, 2017
6RV2
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BU of 6rv2 by Molmil
Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, DECYL-BETA-D-MALTOPYRANOSIDE, ...
Authors:Rodstrom, K.E.J, Pike, A.C.W, Zhang, W, Quigley, A, Speedman, D, Mukhopadhyay, S.M.M, Shrestha, L, Chalk, R, Venkaya, S, Bushell, S.R, Tessitore, A, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2019-05-30
Release date:2019-08-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:A lower X-gate in TASK channels traps inhibitors within the vestibule.
Nature, 582, 2020
4XDK
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BU of 4xdk by Molmil
Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with norfluoxetine
Descriptor: (3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, (3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Pike, A.C.W, Dong, Y.Y, Mackenzie, A, Mukhopadhyay, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2014-12-19
Release date:2015-03-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science, 347, 2015
4XDL
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Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with a brominated fluoxetine derivative.
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[2-bromanyl-4-(trifluoromethyl)phenoxy]-N-methyl-3-phenyl-propan-1-amine, CADMIUM ION, ...
Authors:Mackenzie, A, Pike, A.C.W, Dong, Y.Y, Mukhopadhyay, S, Ruda, G.F, Brennan, P.E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2014-12-19
Release date:2015-03-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science, 347, 2015
4XDJ
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Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in an alternate conformation (FORM 2)
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, POTASSIUM ION, ...
Authors:Pike, A.C.W, Dong, Y.Y, Mackenzie, A, Mukhopadhyay, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2014-12-19
Release date:2015-03-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science, 347, 2015

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