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1LUF
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1luf
CRYSTAL STRUCTURE OF THE MUSK TYROSINE KINASE: INSIGHTS INTO RECEPTOR AUTOREGULATION
Descriptor:Muscle-specific Tyrosine Kinase receptor musk (E.C.2.7.1.112)
Authors:Till, J.H., Becerra, M., Watty, A., Lu, Y., Ma, Y., Neubert, T.A., Burden, S.J., Hubbard, S.R.
Deposit date:2002-05-22
Release date:2002-09-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation.
Structure, 10, 2002
2HEN
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2hen
CRYSTAL STRUCTURE OF THE EPHB2 RECEPTOR KINASE DOMAIN IN COMPLEX WITH ADP
Descriptor:Ephrin type-B receptor 2 (E.C.2.7.10.1)
Authors:Wybenga-Groot, L.E., Sicheri, F., Pawson, T.
Deposit date:2006-06-21
Release date:2007-02-13
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases
EMBO J., 25, 2006
2R4B
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2r4b
ERBB4 KINASE DOMAIN COMPLEXED WITH A THIENOPYRIMIDINE INHIBITOR
Descriptor:Receptor tyrosine-protein kinase erbB-4 (E.C.2.7.10.1)
Authors:Shewchuk, L.M., Uehling, D.E.
Deposit date:2007-08-31
Release date:2008-03-18
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2VWU
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2vwu
EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
Descriptor:EPHRIN TYPE-B RECEPTOR 4 (E.C.2.7.10.1)
Authors:Read, J., Brassington, C.A., Green, I., Mccall, E.J., Valentine, A.L., Barratt, D., Rowsell, S., Packer, M., Mcalister, M.
Deposit date:2008-06-27
Release date:2008-07-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibitors of the Tyrosine Kinase Ephb4. Part 1: Structure-Based Design and Optimization of a Series of 2,4-Bis-Anilinopyrimidines
Bioorg.Med.Chem.Lett., 18, 2008
2VWV
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2vwv
EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
Descriptor:EPHRIN TYPE-B RECEPTOR 4 (E.C.2.7.10.1)
Authors:Read, J., Brassington, C.A., Green, I., Mccall, E.J., Valentine, A.L., Kettle, J.G., Leach, A.G.
Deposit date:2008-06-27
Release date:2008-07-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibitors of the Tyrosine Kinase Ephb4. Part 1: Structure-Based Design and Optimization of a Series of 2,4-Bis-Anilinopyrimidines
Bioorg.Med.Chem.Lett., 18, 2008
2VWW
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2vww
EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
Descriptor:EPHRIN TYPE-B RECEPTOR 4 (E.C.2.7.10.1)
Authors:Read, J., Brassington, C.A., Green, I., Mccall, E.J., Valentine, A.L., Barratt, D., Leach, A.G., Kettle, J.G.
Deposit date:2008-06-27
Release date:2008-07-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibitors of the Tyrosine Kinase Ephb4. Part 1: Structure-Based Design and Optimization of a Series of 2,4-Bis-Anilinopyrimidines
Bioorg.Med.Chem.Lett., 18, 2008
2VWX
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2vwx
EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
Descriptor:EPHRIN TYPE-B RECEPTOR 4 (E.C.2.7.10.1)
Authors:Read, J., Brassington, C.A., Green, I., Mccall, E.J., Valentine, A.L., Barratt, D., Leach, A.G., Kettle, J.G.
Deposit date:2008-06-27
Release date:2008-10-28
Modification date:2009-11-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Inhibitors of the Tyrosine Kinase Ephb4. Part 2: Structure-Based Discovery and Optimisation of 3,5-Bis Substituted Anilinopyrimidines.
Bioorg.Med.Chem.Lett., 18, 2008
2VWY
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2vwy
EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
Descriptor:EPHRIN TYPE-B RECEPTOR 4 (E.C.2.7.10.1)
Authors:Read, J., Brassington, C.A., Green, I., Mccall, E.J., Valentine, A.L., Barratt, D., Leach, A.G., Kettle, J.G.
Deposit date:2008-06-30
Release date:2008-10-28
Modification date:2009-11-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Inhibitors of the Tyrosine Kinase Ephb4. Part 2: Structure-Based Discovery and Optimisation of 3,5-Bis Substituted Anilinopyrimidines.
Bioorg.Med.Chem.Lett., 18, 2008
2VWZ
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2vwz
EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
Descriptor:EPHRIN TYPE-B RECEPTOR 4 (E.C.2.7.10.1)
Authors:Read, J., Brassington, C.A., Green, I., Mccall, E.J., Valentine, A.L., Barratt, D., Leach, A.G., Kettle, J.G.
Deposit date:2008-06-30
Release date:2008-10-28
Modification date:2009-11-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Inhibitors of the Tyrosine Kinase Ephb4. Part 2: Structure-Based Discovery and Optimisation of 3,5-Bis Substituted Anilinopyrimidines.
Bioorg.Med.Chem.Lett., 18, 2008
2VX0
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2vx0
EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
Descriptor:EPHRIN TYPE-B RECEPTOR 4 (E.C.2.7.10.1)
Authors:Read, J., Brassington, C.A., Green, I., Mccall, E.J., Valentine, A.L., Barratt, D., Leach, A.G., Kettle, J.G.
Deposit date:2008-06-30
Release date:2008-10-28
Modification date:2011-03-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibitors of the Tyrosine Kinase Ephb4. Part 1: Structure-Based Design and Optimization of a Series of 2,4-Bis-Anilinopyrimidines.
Bioorg.Med.Chem.Lett., 18, 2008
2VX1
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2vx1
EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
Descriptor:EPHRIN TYPE-B RECEPTOR 4 (E.C.2.7.10.1)
Authors:Read, J., Brassington, C.A., Green, I., Mccall, E.J., Valentine, A.L., Barratt, D., Leach, A.G., Kettle, J.G.
Deposit date:2008-06-30
Release date:2008-10-28
Modification date:2009-11-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Inhibitors of the Tyrosine Kinase Ephb4. Part 2: Structure-Based Discovery and Optimisation of 3,5-Bis Substituted Anilinopyrimidines.
Bioorg.Med.Chem.Lett., 18, 2008
2X9F
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2x9f
EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
Descriptor:EPHRIN TYPE-B RECEPTOR 4 (E.C.2.7.10.1)
Authors:Read, J., Brassington, C.A., Green, I., Mccall, E.J., Valentine, A.L., Barratt, D.
Deposit date:2010-03-17
Release date:2010-09-29
Modification date:2010-10-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Inhibitors of the Tyrosine Kinase Ephb4. Part 3: Identification of Non-Benzodioxole-Based Kinase Inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
2XB7
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2xb7
STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH NVP-TAE684
Descriptor:ALK TYROSINE KINASE RECEPTOR (E.C.2.7.10.1)
Authors:Bossi, R.T., Saccardo, M.B., Ardini, E., Menichincheri, M., Rusconi, L., Magnaghi, P., Orsini, P., Fogliatto, G., Bertrand, J.A.
Deposit date:2010-04-08
Release date:2010-07-28
Modification date:2010-08-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors.
Biochemistry, 49, 2010
2XBA
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2xba
STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PHA-E429
Descriptor:ALK TYROSINE KINASE RECEPTOR (E.C.2.7.10.1)
Authors:Bossi, R.T., Saccardo, M.B., Ardini, E., Menichincheri, M., Rusconi, L., Magnaghi, P., Orsini, P., Fogliatto, G., Bertrand, J.A.
Deposit date:2010-04-08
Release date:2010-07-28
Modification date:2010-08-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors.
Biochemistry, 49, 2010
2XP2
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2xp2
STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB (PF-02341066)
Descriptor:TYROSINE-PROTEIN KINASE RECEPTOR (E.C.2.7.10.1)
Authors:Mctigue, M., Deng, Y., Liu, W., Brooun, A., Timofeevski, S., Marrone, T., Cui, J.J.
Deposit date:2010-08-24
Release date:2010-09-15
Modification date:2011-09-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure Based Drug Design of Crizotinib (Pf-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (C-met) Kinase and Anaplastic Lymphoma Kinase (Alk).
J.Med.Chem, 54, 2011
2XVD
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2xvd
EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
Descriptor:EPHRIN TYPE-B RECEPTOR 4 (E.C.2.7.10.1)
Authors:Read, J., Brassington, C.A., Green, I., Mccall, E.J., Valentine, A.L.
Deposit date:2010-10-25
Release date:2011-06-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inhibitors of the Tyrosine Kinase Ephb4. Part 4: Discovery and Optimization of a Benzylic Alcohol Series.
Bioorg.Med.Chem.Lett., 21, 2011
2YFX
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2yfx
STRUCTURE OF L1196M MUTANT ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB
Descriptor:TYROSINE-PROTEIN KINASE RECEPTOR (E.C.2.7.10.1)
Authors:McTigue, M., Deng, Y., Liu, W., Brooun, A.
Deposit date:2011-04-08
Release date:2011-05-04
Modification date:2014-03-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib.
J.Med.Chem., 57, 2014
2YHV
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2yhv
STRUCTURE OF L1196M MUTANT ANAPLASTIC LYMPHOMA KINASE
Descriptor:ALK TYROSINE KINASE RECEPTOR (E.C.2.7.10.1)
Authors:McTigue, M., Deng, Y., Liu, W., Brooun, A.
Deposit date:2011-05-06
Release date:2011-05-18
Modification date:2014-03-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib.
J.Med.Chem., 57, 2014
2YJR
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2yjr
STRUCTURE OF F1174L MUTANT ANAPLASTIC LYMPHOMA KINASE
Descriptor:ALK TYROSINE KINASE RECEPTOR (E.C.2.7.10.1)
Authors:Mctigue, M., Deng, Y., Liu, W., Brooun, A.
Deposit date:2011-05-23
Release date:2012-06-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of F1174L Mutant Anaplastic Lymphoma Kinase
To be Published
2YJS
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2yjs
STRUCTURE OF C1156Y MUTANT ANAPLASTIC LYMPHOMA KINASE
Descriptor:ALK TYROSINE KINASE RECEPTOR (E.C.2.7.10.1)
Authors:Mctigue, M., Deng, Y., Liu, W., Brooun, A.
Deposit date:2011-05-23
Release date:2012-06-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of C1156Y Mutant Anaplastic Lymphoma Kinase
To be Published
2YN8
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2yn8
EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
Descriptor:EPHRIN TYPE-B RECEPTOR 4 (E.C.2.7.10.1)
Authors:Read, J., Brassington, C.A., Overmann, R.
Deposit date:2012-10-13
Release date:2013-10-23
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Stability and Solubility Engineering of the Ephb4 Tyrosine Kinase Catalytic Domain Using a Rationally Designed Synthetic Library.
Protein Eng.Des.Sel., 26, 2013
3AOX
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3aox
X-RAY CRYSTAL STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CH5424802
Descriptor:ALK tyrosine kinase receptor (E.C.2.7.10.1)
Authors:Nagel, S., Moertl, M., Jestel, A., Fukami, T.A.
Deposit date:2010-10-08
Release date:2011-05-25
Modification date:2012-04-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant
Cancer Cell, 19, 2011
3BBT
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3bbt
CRYSTAL STRUCTURE OF THE ERBB4 KINASE IN COMPLEX WITH LAPATINIB
Descriptor:Receptor tyrosine-protein kinase erbB-4 (E.C.2.7.10.1)
Authors:Qiu, C.
Deposit date:2007-11-11
Release date:2008-02-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase.
Structure, 16, 2008
3BBW
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3bbw
CRYSTAL STRUCTURE OF THE ERBB4 KINASE IN ITS INACTIVE CONFORMATION
Descriptor:Receptor tyrosine-protein kinase erbB-4 (E.C.2.7.10.1)
Authors:Qiu, C.
Deposit date:2007-11-11
Release date:2008-02-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (4 Å)
Cite:Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase.
Structure, 16, 2008
3BCE
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3bce
CRYSTAL STRUCTURE OF THE ERBB4 KINASE
Descriptor:Receptor tyrosine-protein kinase erbB-4 (E.C.2.7.10.1)
Authors:Qiu, C.
Deposit date:2007-11-12
Release date:2008-02-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase.
Structure, 16, 2008
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entries available on 2014-11-19
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