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1AGW
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1agw
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR
Descriptor:FGF RECEPTOR 1, 3-[4-(1-FORMYLPIPERAZIN-4-YL)-BENZYLIDENYL]-2-INDOLINONE
Authors:Mohammadi, M., Schlessinger, J., Hubbard, S.R.
Deposit date:1997-03-25
Release date:1998-03-25
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Science, 276, 1997
1BYG
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1byg
KINASE DOMAIN OF HUMAN C-TERMINAL SRC KINASE (CSK) IN COMPLEX WITH INHIBITOR STAUROSPORINE
Descriptor:PROTEIN (C-TERMINAL SRC KINASE) (2.7.1.112)
Authors:Antson, A.A., Lamers, M.B.A.C., Scott, R.K., Williams, D.H., Hubbard, R.E.
Deposit date:1998-10-14
Release date:1999-10-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine.
J.Mol.Biol., 285, 1999
1FGI
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1fgi
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU5402 INHIBITOR
Descriptor:FGF RECEPTOR 1, 3-[(3-(2-CARBOXETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE
Authors:Mohammadi, M., Schlessinger, J., Hubbard, S.R.
Deposit date:1997-03-22
Release date:1998-04-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Science, 276, 1997
1FGK
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1fgk
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1
Descriptor:FGF RECEPTOR 1
Authors:Mohammadi, M., Schlessinger, J., Hubbard, S.R.
Deposit date:1997-02-08
Release date:1997-07-23
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism.
Cell(Cambridge,Mass.), 86, 1996
1FPU
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1fpu
CRYSTAL STRUCTURE OF ABL KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Descriptor:ABL KINASE
Authors:Schindler, T., Bornmann, W., Pellicena, P., Miller, W.T., Clarkson, B., Kuriyan, J.
Deposit date:2000-08-31
Release date:2000-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural mechanism for STI-571 inhibition of abelson tyrosine kinase.
Science, 289, 2000
1FVR
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1fvr
TIE2 KINASE DOMAIN
Descriptor:TYROSINE-PROTEIN KINASE TIE-2 (E.C.2.7.1.112)
Authors:Shewchuk, L.M., Hassell, A.M., Ellis, B., Holmes, W.D., Davis, R., Horne, E.L., Kadwell, S.H., McKee, D.D., Moore, J.T.
Deposit date:2000-09-20
Release date:2001-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail.
Structure Fold.Des., 8, 2000
1GAG
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1gag
CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH A BISUBSTRATE INHIBITOR
Descriptor:INSULIN RECEPTOR (E.C.2.7.1.112), TYROSINE KINASE DOMAIN, PEPTIDE INHIBITOR
Authors:Parang, K., Till, J.H., Ablooglu, A.J., Kohanski, R.A., Hubbard, S.R., Cole, P.A.
Deposit date:2000-11-29
Release date:2001-01-17
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism-based design of a protein kinase inhibitor.
Nat.Struct.Biol., 8, 2001
1GJO
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1gjo
THE FGFR2 TYROSINE KINASE DOMAIN
Descriptor:FIBROBLAST GROWTH FACTOR RECEPTOR 2 (E.C.2.7.1.112)
Authors:Ceska, T.A., Owens, R., Doyle, C., Hamlyn, P., Crabbe, T., Moffat, D., Davis, J., Martin, R., Perry, M.J.
Deposit date:2001-07-31
Release date:2003-08-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Fgfr2 Tyrosine Kinase Domain
To be Published
1I44
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1i44
CRYSTALLOGRAPHIC STUDIES OF AN ACTIVATION LOOP MUTANT OF THE INSULIN RECEPTOR TYROSINE KINASE
Descriptor:INSULIN RECEPTOR (E.C.2.7.1.112)
Authors:Till, J.H., Ablooglu, A.J., Frankel, M., Kohanski, R.A., Hubbard, S.R.
Deposit date:2001-02-19
Release date:2001-03-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism.
J.Biol.Chem., 276, 2001
1IEP
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1iep
CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL (E.C.2.7.1.112)
Authors:Nagar, B., Bornmann, W., Schindler, T., Clarkson, B., Kuriyan, J.
Deposit date:2001-04-10
Release date:2001-04-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)
Cancer Res., 62, 2002
1IR3
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1ir3
PHOSPHORYLATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH PEPTIDE SUBSTRATE AND ATP ANALOG
Descriptor:INSULIN RECEPTOR, PEPTIDE SUBSTRATE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Hubbard, S.R.
Deposit date:1997-09-22
Release date:1998-01-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog.
EMBO J., 16, 1997
1IRK
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1irk
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR
Descriptor:INSULIN RECEPTOR (TYROSINE KINASE DOMAIN) MUTANT WITH CYS 981 REPLACED BY SER AND TYR 984 REPLACED BY PHE (C981S, Y984F)
Authors:Hubbard, S.R., Wei, L., Ellis, L., Hendrickson, W.A.
Deposit date:1995-01-02
Release date:1995-02-27
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the tyrosine kinase domain of the human insulin receptor.
Nature, 372, 1994
1JQH
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1jqh
IGF-1 RECEPTOR KINASE DOMAIN
Descriptor:IGF-1 receptor kinase(E.C.2.7.1.112)/ PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Pautsch, A., Zoephel, A., Ahorn, H., Spevak, W., Hauptmann, R., Nar, H.
Deposit date:2001-08-07
Release date:2002-04-19
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation.
Structure, 9, 2001
1K2P
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1k2p
CRYSTAL STRUCTURE OF BRUTON'S TYROSINE KINASE DOMAIN
Descriptor:Tyrosine-protein kinase BTK (E.C.2.7.1.112)
Authors:Mao, C., Zhou, M., Uckun, F.M.
Deposit date:2001-09-28
Release date:2002-06-26
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia.
J.Biol.Chem., 276, 2001
1K3A
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1k3a
STRUCTURE OF THE INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR KINASE
Descriptor:INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (E.C.2.7.1.112)/INSULIN RECEPTOR SUBSTRATE-1
Authors:Favelyukis, S., Till, J.H., Hubbard, S.R., Miller, W.T.
Deposit date:2001-10-02
Release date:2001-11-28
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and autoregulation of the insulin-like growth factor 1 receptor kinase.
Nat.Struct.Biol., 8, 2001
1LUF
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1luf
CRYSTAL STRUCTURE OF THE MUSK TYROSINE KINASE: INSIGHTS INTO RECEPTOR AUTOREGULATION
Descriptor:Muscle-specific Tyrosine Kinase receptor musk (E.C.2.7.1.112)
Authors:Till, J.H., Becerra, M., Watty, A., Lu, Y., Ma, Y., Neubert, T.A., Burden, S.J., Hubbard, S.R.
Deposit date:2002-05-22
Release date:2002-09-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation.
Structure, 10, 2002
1M14
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1m14
TYROSINE KINASE DOMAIN FROM EPIDERMAL GROWTH FACTOR RECEPTOR
Descriptor:Epidermal growth factor receptor (E.C.2.7.1.112)
Authors:Stamos, J., Sliwkowski, M.X., Eigenbrot, C.
Deposit date:2002-06-17
Release date:2002-09-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor.
J.Biol.Chem., 277, 2002
1M17
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1m17
EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE DOMAIN WITH 4-ANILINOQUINAZOLINE INHIBITOR ERLOTINIB
Descriptor:Epidermal growth factor receptor (E.C.2.7.1.112)
Authors:Stamos, J., Sliwkowski, M.X., Eigenbrot, C.
Deposit date:2002-06-17
Release date:2002-09-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor.
J.Biol.Chem., 277, 2002
1M52
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1m52
CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH PD173955
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 (E.C.2.7.1.112)
Authors:Nagar, B., Bornmann, W., Pellicena, P., Schindler, T., Veach, D., Miller, W.T., Clarkson, B., Kuriyan, J.
Deposit date:2002-07-08
Release date:2002-09-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and Imatinib (STI-571)
Cancer Res., 62, 2002
1M7N
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1m7n
CRYSTAL STRUCTURE OF UNACTIVATED APO INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR KINASE DOMAIN
Descriptor:Insulin-like growth factor I receptor (E.C.2.7.1.112)
Authors:Munshi, S., Kuo, L.
Deposit date:2002-07-22
Release date:2003-01-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity.
J.Biol.Chem., 277, 2002
1MP8
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1mp8
CRYSTAL STRUCTURE OF FOCAL ADHESION KINASE (FAK)
Descriptor:focal adhesion kinase 1 (E.C.2.7.1.112)
Authors:Nowakowski, J., Cronin, C.N., McRee, D.E., Knuth, M.W., Nelson, C.G., Pavletich, N.P., Rodgers, J., Sang, B.-C., Scheibe, D.N., Swanson, R.V., Thompson, D.A.
Deposit date:2002-09-11
Release date:2003-09-16
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography
Structure, 10, 2002
1OEC
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1oec
FGFR2 KINASE DOMAIN
Descriptor:FIBROBLAST GROWTH FACTOR RECEPTOR 2 (E.C.2.7.1.112)
Authors:Ceska, T.A., Owens, R., Doyle, C., Hamlyn, P., Crabbe, T., Moffat, D., Davis, J., Martin, R., Perry, M.J.
Deposit date:2003-03-24
Release date:2004-10-27
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Crystal Structure of the Fgfr2 Tyrosine Kinase Domain in Complex with 4-Aryl-2-Phenylamino Pyrimidine Angiogenesis Inhibitors
To be Published
1OPJ
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1opj
STRUCTURAL BASIS FOR THE AUTO-INHIBITION OF C-ABL TYROSINE KINASE
Descriptor:Proto-oncogene tyrosine-protein kinase ABL1, MYRISTIC ACID, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE
Authors:Nagar, B., Hantschel, O., Young, M.A., Scheffzek, K., Veach, D., Bornmann, W., Clarkson, B., Superti-Furga, G., Kuriyan, J.
Deposit date:2003-03-06
Release date:2003-04-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
1P14
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1p14
CRYSTAL STRUCTURE OF A CATALYTIC-LOOP MUTANT OF THE INSULIN RECEPTOR TYROSINE KINASE
Descriptor:insulin receptor (E.C.2.7.1.112)
Authors:Li, S., Covino, N.D., Stein, E.G., Till, J.H., Hubbard, S.R.
Deposit date:2003-04-11
Release date:2003-07-22
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor
J.Biol.Chem., 278, 2003
1P4O
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1p4o
STRUCTURE OF APO UNACTIVATED IGF-1R KINASE DOMAIN AT 1.5A RESOLUTION.
Descriptor:Insulin-like growth factor I receptor protein kinase
Authors:Munshi, S., Kornienko, M., Hall, D.L., Darke, P.L., Waxman, L., Kuo, L.C.
Deposit date:2003-04-23
Release date:2003-04-29
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 A resolution.
Acta Crystallogr.,Sect.D, 59, 2003
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