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1TBQ	CRYSTAL STRUCTURE OF INSECT DERIVED DOUBLE DOMAIN KAZAL INHIBITOR RHODNIIN IN COMPLEX WITH THROMBIN Descriptor: RHODNIIN, THROMBIN Authors: Van De Locht, A, Lamba, D, Bode, W. Deposit date: 1995-03-02 Release date: 1996-10-14 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin. EMBO J., 14, 1995
1TBR	CRYSTAL STRUCTURE OF INSECT DERIVED DOUBLE DOMAIN KAZAL INHIBITOR RHODNIIN IN COMPLEX WITH THROMBIN Descriptor: RHODNIIN, THROMBIN Authors: Van De Locht, A, Lamba, D, Bode, W. Deposit date: 1995-03-03 Release date: 1996-10-14 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin. EMBO J., 14, 1995
1LR7	Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue sucrose octasulphate (SOS) Descriptor: SULFATE ION, follistatin Authors: Innis, C.A, Hyvonen, M. Deposit date: 2002-05-15 Release date: 2003-07-29 Last modified: 2022-12-21 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding. J.Biol.Chem., 278, 2003
1LR8	Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue D-myo-inositol hexasulphate (Ins6S) Descriptor: D-MYO-INOSITOL-HEXASULPHATE, Follistatin Authors: Innis, C.A, Hyvonen, M. Deposit date: 2002-05-15 Release date: 2003-07-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding. J.Biol.Chem., 278, 2003
1LR9	STRUCTURE OF Fs1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN Descriptor: Follistatin Authors: Innis, C.A, Hyvonen, M. Deposit date: 2002-05-15 Release date: 2003-07-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding. J.Biol.Chem., 278, 2003
1YU6	Crystal Structure of the Subtilisin Carlsberg:OMTKY3 Complex Descriptor: CALCIUM ION, Ovomucoid, Subtilisin Carlsberg Authors: Maynes, J.T, Cherney, M.M, Qasim, M.A, Laskowski Jr, M, James, M.N.G. Deposit date: 2005-02-11 Release date: 2005-05-03 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structure of the subtilisin Carlsberg-OMTKY3 complex reveals two different ovomucoid conformations. Acta Crystallogr.,Sect.D, 61, 2005
1Z7K	Crystal Structure of Trypsin- Ovomucoid turkey egg white inhibitor complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ovomucoid, Trypsin Authors: Syed Ibrahim, B, Pattabhi, V. Deposit date: 2005-03-25 Release date: 2005-04-05 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of trypsin-turkey egg white inhibitor complex Biochem.Biophys.Res.Commun., 313, 2004
2ARP	Activin A in complex with Fs12 fragment of follistatin Descriptor: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, Follistatin, GLYCEROL, ... Authors: Harrington, A.E, Morris-Triggs, S.A, Ruotolo, B.T, Robinson, C.V, Ohnuma, S, Hyvonen, M. Deposit date: 2005-08-21 Release date: 2006-03-07 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for the inhibition of activin signalling by follistatin Embo J., 25, 2006
2B0U	The Structure of the Follistatin:Activin Complex Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Follistatin, IRIDIUM (III) ION, ... Authors: Thompson, T.B, Lerch, T.F, Cook, R.W, Woodruff, T.K, Jardetzky, T.S. Deposit date: 2005-09-14 Release date: 2005-10-11 Last modified: 2017-10-11 Method: X-RAY DIFFRACTION (2.8 Å) Cite: The Structure of the Follistatin:Activin Complex Reveals Antagonism of Both Type I and Type II Receptor Binding. Dev.Cell, 9, 2005
2P6A	The structure of the Activin:Follistatin 315 complex Descriptor: Follistatin, Inhibin beta A chain, probable fragment of follistatin Authors: Lerch, T.F, Shimasaki, S, Woodruff, T.K, Jardetzky, T.S. Deposit date: 2007-03-16 Release date: 2007-04-03 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions. J.Biol.Chem., 282, 2007
3B4V	X-Ray structure of Activin in complex with FSTL3 Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Inhibin beta A chain, ... Authors: Thompson, T.B. Deposit date: 2007-10-24 Release date: 2008-09-02 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.48 Å) Cite: The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity. J.Biol.Chem., 283, 2008
2KCX	Solution NMR Structure of Kazal-1 Domain of Human Follistatin-related protein 3 (FSTL-3). Northeast Structural Genomics Target HR6186A. Descriptor: Follistatin-related protein 3 Authors: Rossi, P, Chiang, Y, Anderson, S, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) Deposit date: 2008-12-30 Release date: 2009-03-10 Last modified: 2022-03-16 Method: SOLUTION NMR Cite: Solution NMR Structure of Kazal-1 Domain of Human Follistatin-related protein 3 (FSTL-3). Northeast Structural Genomics Target HR6186A. To be Published
3HH2	Crystal structure of the myostatin:follistatin 288 complex Descriptor: CITRIC ACID, Follistatin, Growth/differentiation factor 8, ... Authors: Cash, J.N, Thompson, T.B. Deposit date: 2009-05-14 Release date: 2009-08-04 Last modified: 2017-11-01 Method: X-RAY DIFFRACTION (2.15 Å) Cite: The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding Embo J., 28, 2009
3PIS	Crystal Structure of Carcinoscorpius rotundicauda Serine Protease Inhibitor Domain 1 Descriptor: Kazal-type serine protease inhibitor SPI-1 Authors: Giri, P.K, Tang, X.H, Sivaraman, J. Deposit date: 2010-11-08 Release date: 2010-12-08 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Modifying the Substrate Specificity of Carcinoscorpius rotundicauda Serine Protease Inhibitor Domain 1 to Target Thrombin To be Published
3QTL	Structural Basis for Dual-inhibition Mechanism of a Non-classical Kazal-type Serine Protease Inhibitor from Horseshoe Crab in Complex with Subtilisin Descriptor: Kazal-type serine protease inhibitor SPI-1, Subtilisin-like serin protease Authors: Shenoy, R.T, Sivaraman, J. Deposit date: 2011-02-23 Release date: 2011-06-01 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis for dual-inhibition mechanism of a non-classical kazal-type serine protease inhibitor from horseshoe crab in complex with subtilisin. Plos One, 6, 2011
3SEK	Crystal Structure of the Myostatin:Follistatin-like 3 Complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Follistatin-related protein 3, Growth/differentiation factor 8 Authors: Cash, J.N, Thompson, T.B. Deposit date: 2011-06-10 Release date: 2011-11-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.401 Å) Cite: Structure of myostatinfollistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding. J.Biol.Chem., 287, 2012
3T5O	Crystal Structure of human Complement Component C6 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, Complement component C6, ... Authors: Aleshin, A.E, Stec, B, Bankston, L.A, DiScipio, R.G, Liddington, R.C. Deposit date: 2011-07-27 Release date: 2012-02-01 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.869 Å) Cite: Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC). J.Biol.Chem., 287, 2012
3TJQ	N-domain of HtrA1 Descriptor: CHLORIDE ION, GLYCEROL, PLATINUM (II) ION, ... Authors: Eigenbrot, C, Ultsch, M. Deposit date: 2011-08-24 Release date: 2012-05-16 Last modified: 2012-06-27 Method: X-RAY DIFFRACTION (2.001 Å) Cite: Structural and Functional Analysis of HtrA1 and Its Subdomains. Structure, 20, 2012
4A5W	Crystal structure of C5b6 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COMPLEMENT C5, ... Authors: Hadders, M.A, Bubeck, D, Forneris, F, Pangburn, M, Llorca, O, Lea, S.M, Gros, P. Deposit date: 2011-10-28 Release date: 2012-03-14 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9. Cell Rep., 1, 2012
4E0S	Crystal Structure of C5b-6 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C5, ... Authors: Aleshin, A.E, Stec, B, DiScipio, R, Liddington, R.C. Deposit date: 2012-03-05 Release date: 2012-04-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (4.21 Å) Cite: Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex. J.Biol.Chem., 287, 2012
2N17	NMR structure of a Kazal-type serine protease inhibitor from the subterranean termite defense gland of Coptotermes formosanus Shiraki soldiers Descriptor: Lysozyme-Protease Inhibitor Protein Authors: Negulescu, H, Guo, Y, Garner, T.P, Goodwin, O.Y, Henderson, G, Laine, R.A, Macnaughtan, M.A. Deposit date: 2015-03-23 Release date: 2015-05-06 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: A Kazal-Type Serine Protease Inhibitor from the Defense Gland Secretion of the Subterranean Termite Coptotermes formosanus Shiraki. Plos One, 10, 2015
5JHW	Crystal Structure of the GDF11:Follistatin 288 complex Descriptor: CITRATE ANION, Follistatin, Growth/differentiation factor 11, ... Authors: Walker, R.G, Thompson, T.B. Deposit date: 2016-04-21 Release date: 2017-03-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structural basis for potency differences between GDF8 and GDF11. BMC Biol., 15, 2017
6H03	OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ... Authors: Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D. Deposit date: 2018-07-06 Release date: 2018-12-19 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (5.6 Å) Cite: CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers. Nat Commun, 9, 2018
6H04	Closed conformation of the Membrane Attack Complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ... Authors: Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D. Deposit date: 2018-07-06 Release date: 2018-12-19 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (5.6 Å) Cite: CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers. Nat Commun, 9, 2018
6JZA	Structure of Fstl1 Descriptor: Follistatin-related protein 1 Authors: Liu, X, Ning, W. Deposit date: 2019-04-30 Release date: 2019-08-21 Last modified: 2019-09-25 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and functional study of FK domain of Fstl1. Protein Sci., 28, 2019

 

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