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6TRQ
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BU of 6trq by Molmil
S.c. Scavenger Decapping Enzyme DcpS in complex with the capped RNA dinucleotide m7G-GU
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, L-GUANOSINE-5'-MONOPHOSPHATE, PHOSPHONATE, ...
Authors:Fuchs, A.-L, Neu, A, Sprangers, R.
Deposit date:2019-12-19
Release date:2020-07-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.944 Å)
Cite:Molecular basis of the selective processing of short mRNA substrates by the DcpS mRNA decapping enzyme.
Proc.Natl.Acad.Sci.USA, 117, 2020
6GBS
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BU of 6gbs by Molmil
Crystal Structure of the C. themophilum Scavenger Decapping Enzyme DcpS apo form
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Putative mRNA decapping protein
Authors:Fuchs, A.-L, Neu, A, Sprangers, R.
Deposit date:2018-04-16
Release date:2019-04-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.946 Å)
Cite:Molecular basis of the selective processing of short mRNA substrates by the DcpS mRNA decapping enzyme.
Proc.Natl.Acad.Sci.USA, 117, 2020
5OSY
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BU of 5osy by Molmil
Human Decapping Scavenger enzyme (hDcpS) in complex with m7G(5'S)ppSp(5'S)G mRNA 5' cap analog
Descriptor: GLYCEROL, [(2~{S},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-[[[(2~{S},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-oxidanyl-phosphoryl]oxy-sulfanyl-phosphoryl]oxy-phosphinic acid, m7GpppX diphosphatase
Authors:Warminski, M, Nowak, E, Wojtczak, B.A, Fac-Dabrowska, K, Kubacka, D, Nowicka, A, Sikorski, P.J, Kowalska, J, Jemielity, J, Nowotny, M.
Deposit date:2017-08-18
Release date:2018-05-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes.
J. Am. Chem. Soc., 140, 2018
5BV3
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BU of 5bv3 by Molmil
Yeast Scavenger Decapping Enzyme in complex with m7GDP
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, CHLORIDE ION, SULFATE ION, ...
Authors:Neu, A, Neu, U, Sprangers, R.
Deposit date:2015-06-04
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:An excess of catalytically required motions inhibits the scavenger decapping enzyme.
Nat.Chem.Biol., 11, 2015
4QEB
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BU of 4qeb by Molmil
Dcps in complex with covalent inhibitor targeting Tyrosine
Descriptor: 3-{[(2,4-diaminoquinazolin-5-yl)oxy]methyl}benzenesulfonic acid, PHOSPHATE ION, m7GpppX diphosphatase
Authors:Liu, S.
Deposit date:2014-05-15
Release date:2015-05-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Human Dcps in complex with covalent inhibitor
To be Published
4QDV
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BU of 4qdv by Molmil
Dcps in complex with covalent ligand
Descriptor: 4-{[(2,4-diaminoquinazolin-5-yl)oxy]methyl}benzenesulfonic acid, GLYCEROL, PHOSPHATE ION, ...
Authors:Liu, S.
Deposit date:2014-05-14
Release date:2015-05-20
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Dcps in complex with covalent ligands targeting Tyrosines
To be Published
4QDE
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BU of 4qde by Molmil
Dcps in complex with covalent inhibitor
Descriptor: 2-{[(2,4-diaminoquinazolin-5-yl)oxy]methyl}benzenesulfonic acid, PHOSPHATE ION, m7GpppX diphosphatase
Authors:Liu, S.
Deposit date:2014-05-13
Release date:2015-05-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Dcps in complex with covalent inhibitors
To be Published
3BLA
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BU of 3bla by Molmil
Synthetic Gene Encoded DcpS bound to inhibitor DG153249
Descriptor: 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS
Authors:Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3BL9
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BU of 3bl9 by Molmil
Synthetic Gene Encoded DcpS bound to inhibitor DG157493
Descriptor: 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS
Authors:Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3BL7
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BU of 3bl7 by Molmil
Synthetic Gene Encoded DcpS bound to inhibitor DG156844
Descriptor: 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS
Authors:Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
1XMM
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BU of 1xmm by Molmil
Structure of human Dcps bound to m7GDP
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, N7-METHYL-GUANOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, ...
Authors:Chen, N, Song, H.
Deposit date:2004-10-04
Release date:2005-03-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.
J.Mol.Biol., 347, 2005
1XML
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BU of 1xml by Molmil
Structure of human Dcps
Descriptor: PHOSPHATE ION, heat shock-like protein 1
Authors:Chen, N, Song, H.
Deposit date:2004-10-04
Release date:2005-03-22
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.
J.Mol.Biol., 347, 2005
1VLR
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BU of 1vlr by Molmil
Crystal structure of mRNA decapping enzyme (DcpS) from Mus musculus at 1.83 A resolution
Descriptor: 1,2-ETHANEDIOL, mRNA decapping enzyme
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2004-08-10
Release date:2004-08-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution.
Proteins, 60, 2005
1ST0
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BU of 1st0 by Molmil
Structure of DcpS bound to m7GpppG
Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, YTTRIUM (III) ION, mRNA decapping enzyme
Authors:Gu, M, Fabrega, C, Liu, S.W, Liu, H, Kiledjian, M, Lima, C.D.
Deposit date:2004-03-24
Release date:2004-04-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity
Mol.Cell, 14, 2004
1ST4
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BU of 1st4 by Molmil
Structure of DcpS bound to m7GpppA
Descriptor: P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, YTTRIUM (III) ION, mRNA decapping enzyme
Authors:Gu, M, Fabrega, C, Liu, S.W, Liu, H, Kiledjian, M, Lima, C.D.
Deposit date:2004-03-24
Release date:2004-04-13
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity
Mol.Cell, 14, 2004

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