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1A7A
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1a7a
STRUCTURE OF HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE: DETERMINATION OF A 30 SELENIUM ATOM SUBSTRUCTURE FROM DATA AT A SINGLE WAVELENGTH
Descriptor:S-ADENOSYLHOMOCYSTEINE HYDROLASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (1'R,2'S)-9-(2-HYDROXY-3'-KETO-CYCLOPENTEN-1-YL)ADENINE
Authors:Turner, M.A., Yuan, C.-S., Borchardt, R.T., Hershfield, M.S., Smith, G.D., Howell, P.L.
Deposit date:1998-03-10
Release date:1999-04-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength.
Nat.Struct.Biol., 5, 1998
1B3R
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1b3r
RAT LIVER S-ADENOSYLHOMOCYSTEIN HYDROLASE
Descriptor:S-ADENOSYLHOMOCYSTEINE HYDROLASE (3.3.1.1)
Authors:Hu, Y., Komoto, J., Huang, Y., Takusagawa, F., Gomi, T., Ogawa, H., Takata, Y., Fujioka, M.
Deposit date:1998-12-14
Release date:1998-12-23
Modification date:2010-03-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of S-adenosylhomocysteine hydrolase from rat liver.
Biochemistry, 38, 1999
1D4F
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1d4f
CRYSTAL STRUCTURE OF RECOMBINANT RAT-LIVER D244E MUTANT S-ADENOSYLHOMOCYSTEINE HYDROLASE
Descriptor:S-ADENOSYLHOMOCYSTEINE HYDROLASE (E.C.3.3.1.1)
Authors:Komoto, J., Huang, Y., Takusagawa, F., Gomi, T., Ogawa, H., Takata, Y., Fujioka, M.
Deposit date:2000-06-22
Release date:2001-01-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Effects of site-directed mutagenesis on structure and function of recombinant rat liver S-adenosylhomocysteine hydrolase. Crystal structure of D244E mutant enzyme.
J.Biol.Chem., 275, 2000
1K0U
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1k0u
INHIBITION OF S-ADENOSYLHOMOCYSTEINE HYDROLASE BY "ACYCLIC SUGAR" ADENOSINE ANALOGUE D-ERITADENINE
Descriptor:S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE (E.C.3.3.1.1)
Authors:Takusagawa, F., Huang, Y., Komoto, J., Takata, Y., Gomi, T., Ogawa, H., Fujioka, M., Powell, D.
Deposit date:2001-09-20
Release date:2001-10-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine.
J.Biol.Chem., 277, 2002
1KY4
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1ky4
S-ADENOSYLHOMOCYSTEINE HYDROLASE REFINED WITH NONCRYSTALLOGRAPHIC RESTRAINTS
Descriptor:S-adenosylhomocysteine hydrolase (E.C.3.3.1.1)
Authors:Takata, Y., Takusagawa, F.
Deposit date:2002-02-03
Release date:2002-09-25
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Catalytic Mechanism of S-adenosylhomocysteine Hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
J.Biol.Chem., 277, 2002
1KY5
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1ky5
D244E MUTANT S-ADENOSYLHOMOCYSTEINE HYDROLASE REFINED WITH NONCRYSTALLOGRAPHIC RESTRAINTS
Descriptor:S-adenosylhomocysteine hydrolase (E.C.3.3.1.1)
Authors:Takata, Y., Takusagawa, F.
Deposit date:2002-02-03
Release date:2002-09-25
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Catalytic Mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
J.Biol.Chem., 277, 2002
1LI4
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1li4
HUMAN S-ADENOSYLHOMOCYSTEINE HYDROLASE COMPLEXED WITH NEPLANOCIN
Descriptor:S-adenosylhomocysteine hydrolase, 3.3.1.1
Authors:Yang, X., Hu, Y., Yin, D.H., Turner, M.A., Wang, M., Borchardt, R.T., Howell, P.L., Kuczera, K., Schowen, R.L.
Deposit date:2002-04-17
Release date:2003-05-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: Transition-state stabilization and the avoidance of abortive reactions
Biochemistry, 42, 2003
1V8B
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1v8b
CRYSTAL STRUCTURE OF A HYDROLASE
Descriptor:adenosylhomocysteinase (E.C.3.3.1.1)
Authors:Tanaka, N., Nakanishi, M., Kusakabe, Y., Shiraiwa, K., Kitade, Y., Nakamura, K.T.
Deposit date:2004-01-03
Release date:2004-10-26
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of S-Adenosyl-l-Homocysteine Hydrolase from the Human Malaria Parasite Plasmodium falciparum
J.Mol.Biol., 343, 2004
1XWF
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1xwf
K185N MUTATED S-ADENOSYLHOMOCYSTEINE HYDROLASE
Descriptor:Adenosylhomocysteinase (E.C.3.3.1.1)
Authors:Yamada, T., Takata, Y., Komoto, J., Gomi, T., Ogawa, H., Fujioka, M., Takusagawa, F.
Deposit date:2004-11-01
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Catalytic mechanism of S-adenosylhomocysteine hydrolase: Roles of His 54, Asp130, Glu155, Lys185, and Aspl89.
Int.J.Biochem.Cell Biol., 37, 2005
2H5L
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2h5l
S-ADENOSYLHOMOCYSTEINE HYDROLASE CONTAINING NAD AND 3-DEAZA-D-ERITADENINE
Descriptor:Adenosylhomocysteinase (E.C.3.3.1.1)
Authors:Yamada, T., Komoto, J., Takusagawa, F.
Deposit date:2006-05-26
Release date:2007-04-10
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and function of eritadenine and its 3-deaza analogues: Potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents.
Biochem.Pharm., 73, 2007
2ZIZ
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2ziz
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE IN TERNARY COMPLEX WITH NAD AND 3-DEAZAADENOSINE
Descriptor:Adenosylhomocysteinase (E.C.3.3.1.1)
Authors:Reddy, M.C.M., Gokulan, K., Shetty, N.D., Owen, J.L., Ioerger, T.R., Sacchettini, J.C.
Deposit date:2008-02-29
Release date:2008-09-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Protein Sci., 17, 2008
2ZJ0
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2zj0
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE IN TERNARY COMPLEX WITH NAD AND 2-FLUOROADENOSINE
Descriptor:Adenosylhomocysteinase (E.C.3.3.1.1)
Authors:Reddy, M.C.M., Gokulan, K., Shetty, N.D., Owen, J.L., Ioerger, T.R., Sacchettini, J.C.
Deposit date:2008-02-29
Release date:2008-09-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Protein Sci., 17, 2008
2ZJ1
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2zj1
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE IN TERNARY COMPLEX WITH NAD AND 3'-KETO-ARISTEROMYCIN
Descriptor:Adenosylhomocysteinase (E.C.3.3.1.1)
Authors:Reddy, M.C.M., Gokulan, K., Shetty, N.D., Owen, J.L., Ioerger, T.R., Sacchettini, J.C.
Deposit date:2008-02-29
Release date:2008-09-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Protein Sci., 17, 2008
3CE6
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3ce6
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE IN TERNARY COMPLEX WITH NAD AND ADENOSINE
Descriptor:Adenosylhomocysteinase (E.C.3.3.1.1)
Authors:Reddy, M.C.M., Gokulan, K., Shetty, N.D., Owen, J.L., Ioerger, T.R., Sacchettini, J.C.
Deposit date:2008-02-28
Release date:2008-09-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Protein Sci., 17, 2008
3D64
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3d64
CRYSTAL STRUCTURE OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE FROM BURKHOLDERIA PSEUDOMALLEI
Descriptor:Adenosylhomocysteinase (E.C.3.3.1.1)
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2008-05-18
Release date:2008-06-03
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of S-adenosyl-L-homocysteine hydrolase from Burkholderia pseudomallei.
To be Published
3DHY
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3dhy
CRYSTAL STRUCTURES OF MYCOBACTERIUM TUBERCULOSIS S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE IN TERNARY COMPLEX WITH SUBSTRATE AND INHIBITORS
Descriptor:Adenosylhomocysteinase (E.C.3.3.1.1)
Authors:Shetty, N.D., Ioerger, T.R., Gokulan, K., Reddy, M.C.M., Owen, J.L., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
Deposit date:2008-06-19
Release date:2008-09-09
Modification date:2010-05-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Protein Sci., 17, 2008
3G1U
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3g1u
CRYSTAL STRUCTURE OF LEISHMANIA MAJOR S-ADENOSYLHOMOCYSTEINE HYDROLASE
Descriptor:Adenosylhomocysteinase (E.C.3.3.1.1)
Authors:Siponen, M.I., Welin, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg,T., Kotenyova, T., Lehtio, L., Moche, M, Nilsson, M.E., Nordlund, P., Nyman, T., Persson, C., Sagemark, J, Schutz, P., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Wisniewska, M., Schueler, H., Structural Genomics Consortium (SGC)
Deposit date:2009-01-30
Release date:2009-02-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Leishmania major S-adenosylhomocysteine hydrolase
To be Published
3GLQ
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3glq
CRYSTAL STRUCTURE OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE FROM BURKHOLDERIA PSEUDOMALLEI IN COMPLEX WITH 9-BETA-D-ARABINO-FURANSYL-ADENINE
Descriptor:Adenosylhomocysteinase (E.C.3.3.1.1)
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-03-12
Release date:2009-03-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of S-adenosyl-L-homocysteine hydrolase from Burkholderia pseudomallei in complex with 9-beta-D-arabino-furansyl-adenine
To be Published
3GVP
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3gvp
HUMAN SAHH-LIKE DOMAIN OF HUMAN ADENOSYLHOMOCYSTEINASE 3
Descriptor:Adenosylhomocysteinase 3 (E.C.3.3.1.1)
Authors:Siponen, M.I., Wisniewska, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotenyova, T., Lehtio, L., Moche, M., Nordlund, P., Nyman, T., Persson, C., Sagemark, J., Schutz, P., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Schueler, H.
Deposit date:2009-03-31
Release date:2009-06-09
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Human S-adenosyl homocysteine hydrolase-like 2 protein crystal structure
To be Published
3H9U
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3h9u
S-ADENOSYL HOMOCYSTEINE HYDROLASE (SAHH) FROM TRYPANOSOMA BRUCEI
Descriptor:Adenosylhomocysteinase (E.C.3.3.1.1)
Authors:Siponen, M.I., Schutz, P., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg,T., Kragh Nielsen, T., Kotenyova, T., Kotzsch, A., Moche, M., Nordlund, P., Nyman, T., Persson, C., Sagemark, J., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Wisniewska, M., Schueler, H., Structural Genomics Consortium (SGC)
Deposit date:2009-04-30
Release date:2009-09-29
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of S-adenosyl homocysteine hydrolase (SAHH) from Trypanosoma brucei
To be Published
3MTG
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3mtg
CRYSTAL STRUCTURE OF HUMAN S-ADENOSYL HOMOCYSTEINE HYDROLASE-LIKE 1 PROTEIN
Descriptor:Putative adenosylhomocysteinase 2 (E.C.3.3.1.1)
Authors:Wisniewska, M., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kotenyova, T., Moche, M., Nordlund, P., Nyman, T., Persson, C., Schutz, P., Thorsell, A.G., Tresaugues, L., van der Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Schuler, H., Structural Genomics Consortium (SGC)
Deposit date:2010-04-30
Release date:2010-05-26
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Crystal structure of human S-adenosyl homocysteine hydrolase-like 1 protein
TO BE PUBLISHED
3N58
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3n58
CRYSTAL STRUCTURE OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE FROM BRUCELLA MELITENSIS IN TERNARY COMPLEX WITH NAD AND ADENOSINE, ORTHORHOMBIC FORM
Descriptor:Adenosylhomocysteinase (E.C.3.3.1.1)
Authors:Seattle Structural Genomics Center for Infectious Disease (Ssgcid)
Deposit date:2010-05-24
Release date:2010-06-02
Modification date:2012-03-21
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Crystal structure of S-adenosyl-L-homocysteine hydrolase from brucella melitensis in ternary complex with NAD and adenosine, orthorhombic form
To be Published
3NJ4
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3nj4
FLUORO-NEPLANOCIN A IN HUMAN S-ADENOSYLHOMOCYSTEINE HYDROLASE
Descriptor:Adenosylhomocysteinase (E.C.3.3.1.1)
Authors:Jeong, L.S., Lee, K.M., Hwang, K.Y., Choi, S., Heo, Y.S.
Deposit date:2010-06-17
Release date:2011-05-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues.
J.Med.Chem., 54, 2011
3OND
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3ond
CRYSTAL STRUCTURE OF LUPINUS LUTEUS S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE IN COMPLEX WITH ADENOSINE
Descriptor:Adenosylhomocysteinase (E.C.3.3.1.1)
Authors:Brzezinski, K., Jaskolski, M.
Deposit date:2010-08-28
Release date:2011-08-31
Modification date:2014-02-19
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:High-resolution structures of complexes of plant S-adenosyl-L-homocysteine hydrolase (Lupinus luteus).
Acta Crystallogr.,Sect.D, 68, 2012
3ONE
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3one
CRYSTAL STRUCTURE OF LUPINUS LUTEUS S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE IN COMPLEX WITH ADENINE
Descriptor:Adenosylhomocysteinase (E.C.3.3.1.1)
Authors:Brzezinski, K., Jaskolski, M.
Deposit date:2010-08-28
Release date:2011-08-31
Modification date:2014-02-19
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:High-resolution structures of complexes of plant S-adenosyl-L-homocysteine hydrolase (Lupinus luteus).
Acta Crystallogr.,Sect.D, 68, 2012
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