1H3L
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N-TERMINAL FRAGMENT OF SIGR FROM STREPTOMYCES COELICOLOR
Descriptor:RNA POLYMERASE SIGMA FACTOR
Authors:Li, W., Stevenson, C.E.M., Burton, N., Jakimowicz, P., Paget, M.S.B., Buttner, M.J., Lawson, D.M., Kleanthous, C.
Deposit date:2002-09-10
Release date:2002-10-03
Modification date:2015-09-23
Method:X-RAY DIFFRACTION (2.375 Å)
Cite:Identification and Structure of the Anti-Sigma Factor-Binding Domain of the Disulfide-Stress Regulated Sigma Factor Sigma(R) from Streptomyces Coelicolor
J.Mol.Biol., 323, 2002
2O7G
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CRYSTAL STRUCTURE OF THE PRIBNOW BOX RECOGNITION REGION OF SIGC FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Probable RNA polymerase sigma-C factor
Authors:Thakur, K.G., Joshi, A.M., Gopal, B.
Deposit date:2006-12-11
Release date:2006-12-26
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and biophysical studies on two promoter recognition domains of the extra-cytoplasmic function sigma factor sigma(C) from Mycobacterium tuberculosis.
J.Biol.Chem., 282, 2007
3MZY
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THE CRYSTAL STRUCTURE OF THE RNA POLYMERASE SIGMA-H FACTOR FROM FUSOBACTERIUM NUCLEATUM TO 2.5A
Descriptor:RNA polymerase sigma-H factor
Authors:Stein, A.J., Chhor, G., Clancy, S., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2010-05-13
Release date:2010-06-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Crystal Structure of the RNA polymerase sigma-H factor from Fusobacterium nucleatum to 2.5A
To be Published
1OR7
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI SIGMAE WITH THE CYTOPLASMIC DOMAIN OF ITS ANTI-SIGMA RSEA
Descriptor:RNA polymerase sigma-E factor, Sigma-E factor negative regulatory protein
Authors:Campbell, E.A., Tupy, J.L., Gruber, T.M., Wang, S., Sharp, M.M., Gross, C.A., Darst, S.A.
Deposit date:2003-03-12
Release date:2003-04-15
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA.
Mol.Cell, 11, 2003
2Q1Z
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CRYSTAL STRUCTURE OF RHODOBACTER SPHAEROIDES SIGE IN COMPLEX WITH THE ANTI-SIGMA CHRR
Descriptor:Sigma24, RpoE, Transcriptional activator chrR
Authors:Campbell, E.A., Darst, S.A.
Deposit date:2007-05-25
Release date:2007-09-18
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria.
Mol.Cell, 27, 2007
2Z2S
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CRYSTAL STRUCTURE OF RHODOBACTER SPHAEROIDES SIGE IN COMPLEX WITH THE ANTI-SIGMA CHRR
Descriptor:Sigma24, RpoE, Transcriptional activator chrR
Authors:Darst, S.A., Campbell, E.A.
Deposit date:2007-05-26
Release date:2008-02-05
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria.
Mol.Cell, 27, 2007
4CXF
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STRUCTURE OF CNRH IN COMPLEX WITH THE CYTOSOLIC DOMAIN OF CNRY.
Descriptor:RNA POLYMERASE SIGMA FACTOR CNRH, CNRY
Authors:Maillard, A.P., Girard, E., Ziani, W., Petit-Hartlein, I., Kahn, R., Coves, J.
Deposit date:2014-04-07
Release date:2014-04-30
Modification date:2014-06-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The Crystal Structure of the Anti-Sigma Factor Cnry in Complex with the Sigma Factor Cnrh Shows a New Structural Class of Anti- Sigma Factors Targeting Extracytoplasmic-Function Sigma Factors.
J.Mol.Biol., 426, 2014
4NQW
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS EXTRACYTOPLASMIC FUNCTION SIGMA FACTOR SIGK IN COMPLEX WITH THE CYTOSOLIC DOMAIN OF ITS COGNATE ANTI-SIGMA FACTOR RSKA
Descriptor:ECF RNA polymerase sigma factor SigK, Anti-sigma-K factor RskA
Authors:Shukla, J.K., Gopal, B.
Deposit date:2013-11-25
Release date:2014-01-22
Modification date:2014-04-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the redox sensitivity of the Mycobacterium tuberculosis SigK-RskA sigma-anti-sigma complex
Acta Crystallogr.,Sect.D, 70, 2014
1RP3
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COCRYSTAL STRUCTURE OF THE FLAGELLAR SIGMA/ANTI-SIGMA COMPLEX, SIGMA-28/FLGM
Descriptor:RNA polymerase sigma factor FliA, anti sigma factor FlgM
Authors:Sorenson, M.K., Ray, S.S., Darst, S.A.
Deposit date:2003-12-02
Release date:2004-04-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the Flagellar Sigma/Anti-Sigma Complex Sigma(28)/FlgM Reveals an Intact Sigma Factor in an Inactive Conformation
Mol.Cell, 14, 2004
1SC5
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SIGMA-28(FLIA)/FLGM COMPLEX
Descriptor:RNA polymerase sigma factor FliA, anti sigma factor FlgM
Authors:Sorenson, M.K., Ray, S.S., Darst, S.A.
Deposit date:2004-02-11
Release date:2004-04-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3.26 Å)
Cite:Crystal structure of the flagellar sigma/anti-sigma complex sigma(28)/FlgM reveals an intact sigma factor in an inactive conformation.
Mol.Cell, 14, 2004
1SIG
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CRYSTAL STRUCTURE OF A SIGMA70 SUBUNIT FRAGMENT FROM ESCHERICHIA COLI RNA POLYMERASE
Descriptor:RNA POLYMERASE PRIMARY SIGMA FACTOR
Authors:Malhotra, A., Severinova, E., Darst, S.A.
Deposit date:1997-02-18
Release date:1997-05-15
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase.
Cell(Cambridge,Mass.), 87, 1996
1ZYR
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STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH THE ANTIBIOTIC STREPTOLYDIGIN
Descriptor:DNA-directed RNA polymerase (alpha, beta, beta', omega and sigma chains) (E.C.2.7.7.6)
Authors:Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark, A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
Deposit date:2005-06-10
Release date:2005-09-13
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Cell(Cambridge,Mass.), 122, 2005
2A68
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC RIFABUTIN
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain (E.C.2.7.7.6), RNA polymerase sigma factor rpoD
Authors:Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-01
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A69
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC RIFAPENTIN
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
Authors:Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A6E
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
Authors:Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A6H
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC STERPTOLYDIGIN
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
Authors:Temiakov, D., Zenkin, N., Vassylyeva, M.N., Perederina, A., Tahirov, T.H., Savkina, M., Zorov, S., Nikiforov, V., Igarashi, N., Matsugaki, N., Wakatsuki, S., Severinov, K., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of transcription inhibition by antibiotic streptolydigin.
Mol.Cell, 19, 2005
2BE5
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH INHIBITOR TAGETITOXIN
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
Authors:Vassylyev, D.G., Svetlov, V., Vassylyeva, M.N., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Artsimovitch, I., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-10-22
Release date:2005-11-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for transcription inhibition by tagetitoxin
Nat.Struct.Mol.Biol., 12, 2005
2CW0
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME AT 3.3 ANGSTROMS RESOLUTION
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain (E.C.2.7.7.6), RNA polymerase sigma factor rpoD (E.C.2.7.7.6)
Authors:Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark Jr., A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
Deposit date:2005-06-15
Release date:2005-09-20
Modification date:2012-09-05
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
Cell(Cambridge,Mass.), 122, 2005
3DXJ
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH THE ANTIBIOTIC MYXOPYRONIN
Descriptor:BACTERIAL RNA POLYMERASE ALPHA SUBUNIT; CHAIN A, B, K, L (E.C.2.7.7.6), BACTERIAL RNA POLYMERASE BETA SUBUNIT; CHAIN C, M (E.C.2.7.7.6), BACTERIAL RNA POLYMERASE BETA-PRIME SUBUNIT; CHAIN D, N (E.C.2.7.7.6), BACTERIAL RNA POLYMERASE OMEGA SUBUNIT; CHAIN E, O (E.C.2.7.7.6), BACTERIAL RNA POLYMERASE SIGMA SUBUNIT; CHAIN F, P (E.C.2.7.7.6)
Authors:Das, K., Arnold, E.
Deposit date:2008-07-24
Release date:2008-10-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:The RNA polymerase "switch region" is a target for inhibitors.
Cell(Cambridge,Mass.), 135, 2008
3EQL
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC MYXOPYRONIN
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor rpoD
Authors:Vassylyev, D.G., Vassylyeva, M.N., Artsimovitch, I.
Deposit date:2008-09-30
Release date:2008-10-28
Modification date:2009-01-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Transcription inactivation through local refolding of the RNA polymerase structure.
Nature, 457, 2009
3IYD
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THREE-DIMENSIONAL EM STRUCTURE OF AN INTACT ACTIVATOR-DEPENDENT TRANSCRIPTION INITIATION COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor rpoD, Catabolite gene activator/DNA complex
Authors:Hudson, B.P., Quispe, J., Lara, S., Kim, Y., Berman, H., Arnold, E., Ebright, R.H., Lawson, C.L.
Deposit date:2009-08-01
Release date:2009-11-10
Modification date:2016-02-10
Method:ELECTRON MICROSCOPY (19.799999 Å)
Cite:Three-dimensional EM structure of an intact activator-dependent transcription initiation complex
Proc.Natl.Acad.Sci.USA, 106, 2009
3WOD
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RNA POLYMERASE-GP39 COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor, Putative uncharacterized protein
Authors:Tagami, S., Sekine, S., Minakhin, L., Esyunina, D., Akasaka, R., Shirouzu, M., Kulbachinskiy, A., Severinov, K., Yokoyama, S.
Deposit date:2013-12-26
Release date:2014-03-12
Modification date:2015-03-25
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for promoter specificity switching of RNA polymerase by a phage factor.
Genes Dev., 28, 2014
4G7H
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor
Authors:Zhang, Y., Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Modification date:2012-12-12
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
4G7O
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX CONTAINING 2 NT OF RNA
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor
Authors:Zhang, Y., Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Modification date:2012-12-12
Method:X-RAY DIFFRACTION (2.993 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
4G7Z
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX CONTAINING 5-BRU AT TEMPLATE-STRAND POSITION +1
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor
Authors:Zhang, Y., Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Modification date:2012-12-12
Method:X-RAY DIFFRACTION (3.815 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
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