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5C8H
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BU of 5c8h by Molmil
Crystal structure of ORC2 C-terminal domain
Descriptor: Origin recognition complex subunit 2, UNKNOWN ATOM OR ION
Authors:Tempel, W, Xu, C, Dong, A, Loppnau, P, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2015-06-25
Release date:2015-07-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structure of ORC2 C-terminal domain
To Be Published
7CTE
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BU of 7cte by Molmil
Human Origin Recognition Complex, ORC2-5
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Origin recognition complex subunit 2, Origin recognition complex subunit 3, ...
Authors:Cheng, J, Li, N, Wang, X, Hu, J, Zhai, Y, Gao, N.
Deposit date:2020-08-18
Release date:2021-01-06
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural insight into the assembly and conformational activation of human origin recognition complex.
Cell Discov, 6, 2020
5UJ8
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Human Origin Recognition Complex subunits 2 and 3
Descriptor: Origin recognition complex subunit 2, Origin recognition complex subunit 3
Authors:Tocilj, A, On, K.F, Elkayam, E, Joshua-Tor, L.
Deposit date:2017-01-17
Release date:2017-02-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (6 Å)
Cite:Structure of the active form of human Origin Recognition Complex and its ATPase motor module.
Elife, 6, 2017
7JPQ
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BU of 7jpq by Molmil
ORC-O2-5: Human Origin Recognition Complex (ORC) with subunits 2,3,4,5
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 2, ...
Authors:Jaremko, M.J, Joshua-Tor, L.
Deposit date:2020-08-09
Release date:2020-09-02
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures.
Elife, 9, 2020
4XGC
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BU of 4xgc by Molmil
Crystal structure of the eukaryotic origin recognition complex
Descriptor: CHLORIDE ION, Origin recognition complex subunit 1, Origin recognition complex subunit 2, ...
Authors:Bleichert, F, Botchan, M.R, Berger, J.M.
Deposit date:2014-12-30
Release date:2015-04-01
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of the eukaryotic origin recognition complex.
Nature, 519, 2015
7MCA
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BU of 7mca by Molmil
Structure of the S. cerevisiae origin recognition complex bound to the replication initiator Cdc6 and the ARS1 origin DNA.
Descriptor: Cell division control protein 6, DNA (85-MER), MAGNESIUM ION, ...
Authors:Feng, X, Li, H.
Deposit date:2021-04-01
Release date:2021-06-02
Last modified:2021-08-04
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6.
Nat Commun, 12, 2021
6RQC
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BU of 6rqc by Molmil
Cryo-EM structure of an MCM loading intermediate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (88-MER), ...
Authors:Miller, T.C.R, Locke, J, Costa, A.
Deposit date:2019-05-15
Release date:2019-11-20
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM.
Nature, 575, 2019
5ZR1
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BU of 5zr1 by Molmil
Saccharomyces Cerevisiae Origin Recognition Complex Bound to a 72-bp Origin DNA containing ACS and B1 element
Descriptor: 72bp-oring DNA, ACS305, A-rich, ...
Authors:Li, N, Lam, W.H, Zhai, Y, Cheng, J, Cheng, E, Zhao, Y, Gao, N, Tye, B.K.
Deposit date:2018-04-21
Release date:2018-07-11
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of the origin recognition complex bound to DNA replication origin.
Nature, 559, 2018
6WGI
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BU of 6wgi by Molmil
Atomic model of the mutant OCCM (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) loaded on DNA at 10.5 A resolution
Descriptor: Cell division control protein 6, Cell division cycle protein CDT1, DNA (34-MER), ...
Authors:Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C.
Deposit date:2020-04-05
Release date:2020-07-15
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
6WGG
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BU of 6wgg by Molmil
Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation)
Descriptor: Cell division control protein 6, Cell division cycle protein CDT1, DNA (41-MER), ...
Authors:Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C.
Deposit date:2020-04-05
Release date:2020-07-15
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (8.1 Å)
Cite:Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
6WGC
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BU of 6wgc by Molmil
Atomic model of semi-attached mutant OCCM-DNA complex (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation)
Descriptor: Cell division control protein 6, DNA (41-MER), DNA replication licensing factor MCM3, ...
Authors:Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C.
Deposit date:2020-04-05
Release date:2020-07-15
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
5UJM
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BU of 5ujm by Molmil
Structure of the active form of human Origin Recognition Complex and its ATPase motor module
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ...
Authors:Tocilj, A, On, K, Yuan, Z, Sun, J, Elkayam, E, Li, H, Stillman, B, Joshua-Tor, L.
Deposit date:2017-01-18
Release date:2017-02-08
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (18 Å)
Cite:Structure of the active form of human Origin Recognition Complex and its ATPase motor module.
Elife, 6, 2017
5V8F
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BU of 5v8f by Molmil
Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1
Descriptor: Cell division control protein 6, Cell division cycle protein CDT1, DNA (39-MER), ...
Authors:Yuan, Z, Riera, A, Bai, L, Sun, J, Spanos, C, Chen, Z.A, Barbon, M, Rappsilber, J, Stillman, B, Speck, C, Li, H.
Deposit date:2017-03-21
Release date:2017-05-10
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.
Nat. Struct. Mol. Biol., 24, 2017
7TJK
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BU of 7tjk by Molmil
S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 2) with docked Orc6 N-terminal domain
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ...
Authors:Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F.
Deposit date:2022-01-16
Release date:2022-10-05
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
Nat Commun, 13, 2022
7TJJ
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BU of 7tjj by Molmil
S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 1) with docked Orc6 N-terminal domain
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ...
Authors:Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F.
Deposit date:2022-01-16
Release date:2022-10-05
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
Nat Commun, 13, 2022
7TJH
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BU of 7tjh by Molmil
S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 1) with flexible Orc6 N-terminal domain
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ...
Authors:Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F.
Deposit date:2022-01-16
Release date:2022-10-05
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
Nat Commun, 13, 2022
7TJI
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BU of 7tji by Molmil
S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 2) with flexible Orc6 N-terminal domain
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ...
Authors:Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F.
Deposit date:2022-01-16
Release date:2022-10-05
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
Nat Commun, 13, 2022
7TJF
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BU of 7tjf by Molmil
S. cerevisiae ORC bound to 84 bp ARS1 DNA
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA, 84 bp ARS1, ...
Authors:Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F.
Deposit date:2022-01-16
Release date:2023-01-18
Last modified:2023-02-22
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
Nat Commun, 13, 2022
7CTF
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BU of 7ctf by Molmil
Human origin recognition complex 1-5 State II
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Origin recognition complex subunit 1, Origin recognition complex subunit 2, ...
Authors:Cheng, J, Li, N, Wang, X, Hu, J, Zhai, Y, Gao, N.
Deposit date:2020-08-18
Release date:2021-01-06
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structural insight into the assembly and conformational activation of human origin recognition complex.
Cell Discov, 6, 2020
7CTG
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BU of 7ctg by Molmil
Human Origin Recognition Complex, ORC1-5 State I
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Origin recognition complex subunit 1, Origin recognition complex subunit 2, ...
Authors:Cheng, J, Li, N, Wang, X, Hu, J, Zhai, Y, Gao, N.
Deposit date:2020-08-18
Release date:2021-01-06
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Structural insight into the assembly and conformational activation of human origin recognition complex.
Cell Discov, 6, 2020
7JPP
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BU of 7jpp by Molmil
ORC-O2WH: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC1 AAA+ domain
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ...
Authors:Jaremko, M.J, Joshua-Tor, L.
Deposit date:2020-08-09
Release date:2020-09-09
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures.
Elife, 9, 2020
7JK4
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BU of 7jk4 by Molmil
Structure of Drosophila ORC bound to AT-rich DNA and Cdc6
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein, DNA (34-MER), ...
Authors:Schmidt, J.M, Bleichert, F.
Deposit date:2020-07-27
Release date:2020-09-09
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6.
Nat Commun, 11, 2020
7JGS
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BU of 7jgs by Molmil
Structure of Drosophila ORC bound to poly(dA/dT) DNA and Cdc6 (conformation 2)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, AT22044p1, Cell division control protein, ...
Authors:Schmidt, J.M, Bleichert, F.
Deposit date:2020-07-19
Release date:2020-09-09
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6.
Nat Commun, 11, 2020
7JK6
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BU of 7jk6 by Molmil
Structure of Drosophila ORC in the active conformation
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ...
Authors:Schmidt, J.M, Bleichert, F.
Deposit date:2020-07-27
Release date:2020-09-09
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6.
Nat Commun, 11, 2020
7JK2
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BU of 7jk2 by Molmil
Structure of Drosophila ORC bound to poly(dA/dT) DNA and Cdc6 (conformation 1)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein, DNA (33-MER), ...
Authors:Schmidt, J.M, Bleichert, F.
Deposit date:2020-07-27
Release date:2020-09-09
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6.
Nat Commun, 11, 2020

 

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