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5MWW
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BU of 5mww by Molmil
Sigma1.1 domain of sigmaA from Bacillus subtilis
Descriptor: RNA polymerase sigma factor SigA
Authors:Zachrdla, M, Padrta, P, Rabatinova, A, Sanderova, H, Barvik, I, Krasny, L, Zidek, L.
Deposit date:2017-01-20
Release date:2017-06-14
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structure of domain 1.1 of the sigma (A) factor from Bacillus subtilis is preformed for binding to the RNA polymerase core.
J. Biol. Chem., 292, 2017
2K6X
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BU of 2k6x by Molmil
Autoregulation of a Group 1 Bacterial Sigma Factor Involves the Formation of a Region 1.1- Induced Compacted Structure
Descriptor: RNA polymerase sigma factor rpoD
Authors:Schwartz, E.C, Shekhtman, A, Dutta, K, Pratt, M.R, Cowburn, D, Darst, S, Muir, T.W.
Deposit date:2008-07-28
Release date:2008-10-28
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Autoregulation of a Group 1 Bacterial Sigma Factor Involves the Formation of a Region 1.1 - Induced Compacted Structure
Chem.Biol., 15, 2008
8U3B
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BU of 8u3b by Molmil
Cryo-EM structure of E. coli NarL-transcription activation complex at 3.2A
Descriptor: DNA (69-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Liu, B, Kompaniiets, D, Wang, D.
Deposit date:2023-09-07
Release date:2024-01-17
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Structural basis for transcription activation by the nitrate-responsive regulator NarL.
Nucleic Acids Res., 52, 2024
8AD1
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BU of 8ad1 by Molmil
RNA polymerase at U-rich pause bound to RNA putL triple mutant - pause prone, closed clamp state
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Dey, S, Weixlbaumer, A.
Deposit date:2022-07-07
Release date:2022-10-19
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural insights into RNA-mediated transcription regulation in bacteria.
Mol.Cell, 82, 2022
8FTD
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BU of 8ftd by Molmil
Structure of Escherichia coli CedA in complex with transcription initiation complex
Descriptor: CHAPSO, Cell division activator CedA, DNA-directed RNA polymerase subunit alpha, ...
Authors:Liu, M, Vassyliev, N, Nudler, E.
Deposit date:2023-01-11
Release date:2024-01-10
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:General transcription factor from Escherichia coli with a distinct mechanism of action.
Nat.Struct.Mol.Biol., 31, 2024
3IYD
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BU of 3iyd by Molmil
Three-dimensional EM structure of an intact activator-dependent transcription initiation complex
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator, DNA (98-MER), ...
Authors:Hudson, B.P, Quispe, J, Lara, S, Kim, Y, Berman, H, Arnold, E, Ebright, R.H, Lawson, C.L.
Deposit date:2009-08-01
Release date:2009-11-10
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (19.799999 Å)
Cite:Three-dimensional EM structure of an intact activator-dependent transcription initiation complex
Proc.Natl.Acad.Sci.USA, 106, 2009
6JNX
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BU of 6jnx by Molmil
Cryo-EM structure of a Q-engaged arrested complex
Descriptor: Antiterminator Q protein, DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Feng, Y, Shi, J.
Deposit date:2019-03-18
Release date:2019-06-12
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.08 Å)
Cite:Structural basis of Q-dependent transcription antitermination.
Nat Commun, 10, 2019
6VJS
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BU of 6vjs by Molmil
Escherichia coli RNA polymerase and ureidothiophene-2-carboxylic acid complex
Descriptor: 3-{[benzyl(ethyl)carbamoyl]amino}-5-(4-phenoxyphenyl)thiophene-2-carboxylic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Murakami, K.S, Molodtsov, V.
Deposit date:2020-01-17
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (4.02 Å)
Cite:Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus -Based Wound Infection Model in SKH1 Mice.
Acs Infect Dis., 6, 2020
6B6H
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BU of 6b6h by Molmil
The cryo-EM structure of a bacterial class I transcription activation complex
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Liu, B, Hong, C, Huang, R, Yu, Z, Steitz, T.A.
Deposit date:2017-10-02
Release date:2017-11-15
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis of bacterial transcription activation.
Science, 358, 2017
7SZK
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BU of 7szk by Molmil
Cryo-EM structure of 27a bound to E. coli RNAP and rrnBP1 promoter complex
Descriptor: (2S,7R,7aR,13aP,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,21,23-trihydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-12-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1,6,15-trioxo-1,2,7,7a-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate, DNA (5'-D(P*CP*TP*CP*GP*TP*AP*GP*AP*GP*TP*CP*CP*GP*TP*GP*TP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ...
Authors:Shin, Y, Murakami, K.S.
Deposit date:2021-11-28
Release date:2022-07-13
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis.
Acs Infect Dis., 8, 2022
7SZJ
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BU of 7szj by Molmil
Cryo-EM structure of Rifamycin bound to E. coli RNAP and rrnBP1 promoter complex
Descriptor: DNA (49-MER), DNA (57-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Shin, Y, Murakami, K.S.
Deposit date:2021-11-28
Release date:2022-07-13
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis.
Acs Infect Dis., 8, 2022
8IGR
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BU of 8igr by Molmil
Cryo-EM structure of CII-dependent transcription activation complex
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y.
Deposit date:2023-02-21
Release date:2023-05-17
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of lambda CII-dependent transcription activation.
Structure, 31, 2023
8IGS
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BU of 8igs by Molmil
Cryo-EM structure of RNAP-promoter open complex at lambda promoter PRE
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y.
Deposit date:2023-02-21
Release date:2023-05-17
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of lambda CII-dependent transcription activation.
Structure, 31, 2023
8JO2
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BU of 8jo2 by Molmil
Structural basis of transcriptional activation by the OmpR/PhoB-family response regulator PmrA
Descriptor: DNA (65-MER), DNA-binding transcriptional regulator BasR, DNA-directed RNA polymerase subunit alpha, ...
Authors:Lou, Y.-C, Huang, H.-Y, Chen, C, Wu, K.-P.
Deposit date:2023-06-06
Release date:2023-08-30
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:Structural basis of transcriptional activation by the OmpR/PhoB-family response regulator PmrA.
Nucleic Acids Res., 51, 2023
6C9Y
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BU of 6c9y by Molmil
Cryo-EM structure of E. coli RNAP sigma70 holoenzyme
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Narayanan, A, Vago, F, Li, K, Qayyum, M.Z, Yenool, D, Jiang, W, Murakami, K.S.
Deposit date:2018-01-29
Release date:2018-02-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.25 Å)
Cite:Cryo-EM structure ofEscherichia colisigma70RNA polymerase and promoter DNA complex revealed a role of sigma non-conserved region during the open complex formation.
J. Biol. Chem., 293, 2018
6BYU
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BU of 6byu by Molmil
X-ray crystal structure of Escherichia coli RNA polymerase (RpoB-H526Y) and ppApp complex
Descriptor: (5R)-5-(6-amino-9H-purin-9-yl)-2-({[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}methyl)-4-oxo-4,5-dihydrofuran-3-yl trihydrogen diphosphate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Murakami, K.S, Molodtsov, V.
Deposit date:2017-12-21
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure-function comparisons of (p)ppApp vs (p)ppGpp for Escherichia coli RNA polymerase binding sites and for rrnB P1 promoter regulatory responses in vitro.
Biochim. Biophys. Acta, 1861, 2018
6CA0
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BU of 6ca0 by Molmil
Cryo-EM structure of E. coli RNAP sigma70 open complex
Descriptor: DNA (35-MER), DNA (45-MER), DNA (5'-D(P*GP*CP*CP*GP*CP*GP*TP*CP*AP*GP*A)-3'), ...
Authors:Narayanan, A, Vago, F, Li, K, Qayyum, M.Z, Yernool, D, Jiang, W, Murakami, K.S.
Deposit date:2018-01-29
Release date:2018-02-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.75 Å)
Cite:Cryo-EM structure ofEscherichia colisigma70RNA polymerase and promoter DNA complex revealed a role of sigma non-conserved region during the open complex formation.
J. Biol. Chem., 293, 2018
6CUX
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BU of 6cux by Molmil
Escherichia coli RpoB S531L mutant RNA polymerase holoenzyme in complex with Kanglemycin A
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Molodtsov, V, Murakami, K.S.
Deposit date:2018-03-26
Release date:2018-07-25
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (4.104 Å)
Cite:Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.
Mol. Cell, 72, 2018
4JKR
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BU of 4jkr by Molmil
Crystal Structure of E. coli RNA Polymerase in complex with ppGpp
Descriptor: DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA', DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Zuo, Y, Wang, Y, Steitz, T.A.
Deposit date:2013-03-11
Release date:2013-05-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex.
Mol.Cell, 50, 2013
4JK1
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BU of 4jk1 by Molmil
X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with Guanosine tetraphosphate (ppGpp)
Descriptor: Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ...
Authors:Murakami, K.S.
Deposit date:2013-03-09
Release date:2013-04-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res., 41, 2013
4JK2
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BU of 4jk2 by Molmil
X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with guanosine pentaphosphate (pppGpp)
Descriptor: Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ...
Authors:Murakami, K.S.
Deposit date:2013-03-09
Release date:2013-04-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (4.201 Å)
Cite:Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res., 41, 2013
4KMU
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BU of 4kmu by Molmil
X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Rifampin
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
4KN4
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BU of 4kn4 by Molmil
X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2b
Descriptor: Benzoxazinorifamycin-2b, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.965 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
4KN7
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BU of 4kn7 by Molmil
X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2c
Descriptor: Benzoxazinorifamycin-2c, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.686 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
4LK1
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BU of 4lk1 by Molmil
Crystal Structure Analysis of the E.coli holoenzyme
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Bae, B, Darst, S.A.
Deposit date:2013-07-05
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.8369 Å)
Cite:Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
Proc.Natl.Acad.Sci.USA, 110, 2013

217705

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