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2BFX
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2bfx
MECHANISM OF AURORA-B ACTIVATION BY INCENP AND INHIBITION BY HESPERADIN.
Descriptor:AURORA KINASE B-A (E.C.2.7.11.1), INNER CENTROMERE PROTEIN A
Authors:Sessa, F., Mapelli, M., Ciferri, C., Tarricone, C., Areces, L.B., Schneider, T.R., Stukenberg, P.T., Musacchio, A.
Deposit date:2004-12-15
Release date:2005-05-03
Modification date:2014-05-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin
Mol.Cell, 18, 2005
2BFY
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2bfy
COMPLEX OF AURORA-B WITH INCENP AND HESPERIDIN.
Descriptor:AURORA KINASE B-A (E.C.2.7.11.1), INNER CENTROMERE PROTEIN A
Authors:Sessa, F., Mapelli, M., Ciferri, C., Tarricone, C., Areces, L.B., Schneider, T.R., Stukenberg, P.T., Musacchio, A.
Deposit date:2004-12-15
Release date:2005-05-03
Modification date:2014-05-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin
Mol.Cell, 18, 2005
2VGO
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2vgo
CRYSTAL STRUCTURE OF AURORA B KINASE IN COMPLEX WITH REVERSINE INHIBITOR
Descriptor:SERINE/THREONINE-PROTEIN KINASE 12-A (E.C.2.7.11.1), INNER CENTROMERE PROTEIN A
Authors:D'Alise, A.M., Amabile, G., Iovino, M., Di Giorgio, F.P., Bartiromo, M., Sessa, F., Villa, F., Musacchio, A., Cortese, R.
Deposit date:2007-11-15
Release date:2008-10-28
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Reversine, a Novel Aurora Kinases Inhibitor, Inhibits Colony Formation of Human Acute Myeloid Leukemia Cells.
Mol.Cancer Ther., 7, 2008
2VGP
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2vgp
CRYSTAL STRUCTURE OF AURORA B KINASE IN COMPLEX WITH A AMINOTHIAZOLE INHIBITOR
Descriptor:SERINE/THREONINE-PROTEIN KINASE 12-A (E.C.2.7.11.1), INNER CENTROMERE PROTEIN A
Authors:Andersen, C.B., Wan, Y., Chang, J.W., Lee, C., Liu, Y., Sessa, F., Villa, F., Nallan, L., Musacchio, A., Gray, N.S.
Deposit date:2007-11-15
Release date:2008-02-26
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of Selective Aminothiazole Aurora Kinase Inhibitors
Acs Chem.Biol., 3, 2008
2VRX
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2vrx
STRUCTURE OF AURORA B KINASE IN COMPLEX WITH ZM447439
Descriptor:SERINE/THREONINE-PROTEIN KINASE 12-A (E.C.2.7.11.1), INNER CENTROMERE PROTEIN A
Authors:Girdler, F., Sessa, F., Patercoli, S., Villa, F., Ridgway, E., Musacchio, A., Taylor, S.S.
Deposit date:2008-04-16
Release date:2008-07-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Molecular Basis of Drug Resistance in Aurora Kinases.
Chem.Biol., 15, 2008
3ZTX
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3ztx
AURORA KINASE SELECTIVE INHIBITORS IDENTIFIED USING A TAXOL-INDUCED CHECKPOINT SENSITIVITY SCREEN.
Descriptor:SERINE/THREONINE-PROTEIN KINASE 12-A (E.C.2.7.11.1), INNER CENTROMERE PROTEIN A
Authors:Kwiatkowski, N., Villa, F., Musacchio, A., Gray, N.
Deposit date:2011-07-12
Release date:2012-02-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Selective Aurora Kinase Inhibitors Identified Using a Taxol- Induced Checkpoint Sensitivity Screen.
Acs Chem.Biol., 7, 2012
4AF3
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4af3
HUMAN AURORA B KINASE IN COMPLEX WITH INCENP AND VX-680
Descriptor:AURORA KINASE B (E.C.2.7.11.1), INNER CENTROMERE PROTEIN
Authors:Elkins, J.M., Vollmar, M., Wang, J., Picaud, S., Arrowsmith, C.H., Edwards, A., Bountra, C., Von Delft, F., Knapp, S.
Deposit date:2012-01-16
Release date:2012-04-11
Modification date:2012-09-26
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal Structure of Human Aurora B in Complex with Incenp and Vx-680.
J.Med.Chem., 55, 2012
4B8L
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4b8l
AURORA B KINASE P353G MUTANT
Descriptor:AURORA KINASE B-A (E.C.2.7.11.1), INNER CENTROMERE PROTEIN A
Authors:Sessa, F., Villa, F.
Deposit date:2012-08-28
Release date:2013-07-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and Biochemical Analysis of an Aurora B Kinase Mutant Reveals a Multistep Activation Mechanism
To be Published
4B8M
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4b8m
AURORA B KINASE IN COMPLEX WITH VX-680
Descriptor:AURORA KINASE B-A (E.C.2.7.11.1), INNER CENTROMERE PROTEIN A
Authors:Sessa, F., Villa, F.
Deposit date:2012-08-28
Release date:2013-07-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Biochemical Analysis of an Aurora B Kinase Mutant Reveals a Multistep Activation Mechanism
To be Published
4C2V
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4c2v
AURORA B KINASE IN COMPLEX WITH THE SPECIFIC INHIBITOR BARASERTIB
Descriptor:AURORA KINASE B-A (E.C.2.7.11.1), INNER CENTROMERE PROTEIN A
Authors:Sessa, F., Villa, F.
Deposit date:2013-08-20
Release date:2014-02-26
Modification date:2014-03-19
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structure of Aurora B-Incenp in Complex with Barasertib Reveals a Potential Transinhibitory Mechanism
Acta Crystallogr.,Sect.F, 70, 2014
4C2W
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4c2w
CRYSTAL STRUCTURE OF AURORA B IN COMPLEX WITH AMP-PNP
Descriptor:AURORA KINASE B-A (E.C.2.7.11.1), INNER CENTROMERE PROTEIN A
Authors:Sessa, F., Villa, F.
Deposit date:2013-08-20
Release date:2014-02-26
Modification date:2014-03-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of Aurora B-Incenp in Complex with Barasertib Reveals a Potential Transinhibitory Mechanism
Acta Crystallogr.,Sect.F, 70, 2014
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103735
entries available on 2014-10-01
00:00 UTC / 09:00 JST