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7Z6O
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BU of 7z6o by Molmil
X-Ray studies of Ku70/80 reveal the binding site for IP6
Descriptor: DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ...
Authors:Varela, P.F, Charbonnier, J.B.
Deposit date:2022-03-14
Release date:2023-08-30
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Nucleic Acids Res., 51, 2023
8BOT
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BU of 8bot by Molmil
Cryo-EM structure of NHEJ supercomplex(trimer)
Descriptor: DNA (24-MER), DNA (27-MER), DNA (28-MER), ...
Authors:Hardwick, S.W, Chaplin, A.K.
Deposit date:2022-11-15
Release date:2023-06-28
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (7.76 Å)
Cite:Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ.
Structure, 31, 2023
8ASC
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BU of 8asc by Molmil
Ku70/80 binds to the Ku-binding motif of PAXX
Descriptor: DNA (5'-D(P*CP*GP*GP*AP*TP*CP*GP*AP*GP*GP*GP*CP*CP*CP*GP*AP*TP*AP*T)-3'), DNA (5'-D(P*GP*GP*GP*CP*CP*CP*TP*CP*GP*AP*TP*CP*CP*G)-3'), Protein PAXX, ...
Authors:Seif El Dahan, M, Ropars, V, Charbonnier, J.B.
Deposit date:2022-08-19
Release date:2023-06-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
8EZB
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BU of 8ezb by Molmil
NHEJ Long-range complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ...
Authors:Chen, S, He, Y.
Deposit date:2022-10-31
Release date:2023-06-14
Method:ELECTRON MICROSCOPY (8.9 Å)
Cite:Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ.
Sci Adv, 9, 2023
8EZA
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BU of 8eza by Molmil
NHEJ Long-range complex with PAXX
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ...
Authors:Chen, S, He, Y.
Deposit date:2022-10-31
Release date:2023-06-14
Method:ELECTRON MICROSCOPY (4.39 Å)
Cite:Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ.
Sci Adv, 9, 2023
7ZYG
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BU of 7zyg by Molmil
CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF
Descriptor: DNA, Non-homologous end-joining factor 1, PHOSPHATE ION, ...
Authors:Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K.
Deposit date:2022-05-24
Release date:2023-06-07
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (2.68 Å)
Cite:PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
8BH3
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BU of 8bh3 by Molmil
DNA-PK Ku80 mediated dimer bound to PAXX
Descriptor: DNA (25-MER), DNA (26-MER), DNA (27-MER), ...
Authors:Hardwick, S.W, Chaplin, A.K.
Deposit date:2022-10-28
Release date:2023-06-07
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (4.55 Å)
Cite:PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
8BHV
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BU of 8bhv by Molmil
DNA-PK XLF mediated dimer bound to PAXX
Descriptor: DNA (24-MER), DNA (26-MER), DNA (27-MER), ...
Authors:Hardwick, S.W, Chaplin, A.K.
Deposit date:2022-11-01
Release date:2023-06-07
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (4.51 Å)
Cite:PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
8BHY
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BU of 8bhy by Molmil
DNA-PK Ku80 mediated dimer bound to PAXX and XLF
Descriptor: DNA (25-MER), DNA (26-MER), DNA (27-MER), ...
Authors:Hardwick, S.W, Chaplin, A.K.
Deposit date:2022-11-01
Release date:2023-06-07
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (5.33 Å)
Cite:PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
7ZWA
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BU of 7zwa by Molmil
CryoEM structure of Ku heterodimer bound to DNA and PAXX
Descriptor: DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*T)-3'), PHOSPHATE ION, ...
Authors:Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K.
Deposit date:2022-05-19
Release date:2023-05-31
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
7ZVT
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BU of 7zvt by Molmil
CryoEM structure of Ku heterodimer bound to DNA
Descriptor: DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*T)-3'), DNA (5'-D(P*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*TP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ...
Authors:Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K.
Deposit date:2022-05-17
Release date:2023-05-24
Last modified:2023-12-06
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Nucleic Acids Res., 51, 2023
7ZT6
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BU of 7zt6 by Molmil
Cryo-EM structure of Ku 70/80 bound to inositol hexakisphosphate
Descriptor: INOSITOL HEXAKISPHOSPHATE, X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6
Authors:Kefala Stavridi, A, Chaplin, A.K, Blundell, T.L.
Deposit date:2022-05-09
Release date:2023-05-17
Last modified:2023-12-06
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Nucleic Acids Res., 51, 2023
7Z88
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BU of 7z88 by Molmil
DNA-PK in the intermediate state
Descriptor: (~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol, DNA (26-MER), DNA-dependent protein kinase catalytic subunit, ...
Authors:Liang, S, Blundell, T.L.
Deposit date:2022-03-16
Release date:2023-01-18
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Human DNA-dependent protein kinase activation mechanism.
Nat.Struct.Mol.Biol., 30, 2023
7Z87
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BU of 7z87 by Molmil
DNA-PK in the active state
Descriptor: (~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol, DNA (26-MER), DNA-dependent protein kinase catalytic subunit, ...
Authors:Liang, S, Blundell, T.L.
Deposit date:2022-03-16
Release date:2023-01-18
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:Human DNA-dependent protein kinase activation mechanism.
Nat.Struct.Mol.Biol., 30, 2023
8AG4
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BU of 8ag4 by Molmil
Vaccinia C16 protein bound to Ku70/Ku80
Descriptor: Protein C10, X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6
Authors:Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O.
Deposit date:2022-07-19
Release date:2022-11-09
Last modified:2022-11-30
Method:ELECTRON MICROSCOPY (2.46 Å)
Cite:Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus.
Nat Commun, 13, 2022
8AG5
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BU of 8ag5 by Molmil
Vaccinia C16 protein bound to Ku70/Ku80
Descriptor: Ku70-Xrcc6, Protein C10, X-ray repair cross-complementing protein 5
Authors:Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O.
Deposit date:2022-07-19
Release date:2022-11-09
Last modified:2022-11-30
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus.
Nat Commun, 13, 2022
7SGL
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BU of 7sgl by Molmil
DNA-PK complex of DNA end processing
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA-dependent protein kinase catalytic subunit, Hairpin_1, ...
Authors:Liu, L, Li, J, Chen, X, Yang, W, Gellert, M.
Deposit date:2021-10-06
Release date:2022-01-12
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Mol.Cell, 82, 2022
7SU3
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BU of 7su3 by Molmil
CryoEM structure of DNA-PK complex VII
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), ...
Authors:Chen, X, Liu, L, Gellert, M, Yang, W.
Deposit date:2021-11-16
Release date:2022-01-12
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Mol.Cell, 82, 2022
7SUD
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BU of 7sud by Molmil
CryoEM structure of DNA-PK complex VIII
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA-dependent protein kinase catalytic subunit, MAGNESIUM ION, ...
Authors:Chen, X, Liu, L, Gellert, M, Yang, W.
Deposit date:2021-11-16
Release date:2022-01-12
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Mol.Cell, 82, 2022
7NFC
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BU of 7nfc by Molmil
Cryo-EM structure of NHEJ super-complex (dimer)
Descriptor: DNA (27-MER), DNA (28-MER), DNA ligase 4, ...
Authors:Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2021-02-05
Release date:2021-08-18
Last modified:2021-09-22
Method:ELECTRON MICROSCOPY (4.14 Å)
Cite:Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Mol.Cell, 81, 2021
7NFE
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BU of 7nfe by Molmil
Cryo-EM structure of NHEJ super-complex (monomer)
Descriptor: DNA (5'-D(P*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*CP*TP*AP*TP*TP*AP*TP*TP*AP*TP*G)-3'), DNA (5'-D(P*TP*AP*AP*TP*AP*AP*TP*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*AP*G)-3'), DNA ligase 4, ...
Authors:Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2021-02-06
Release date:2021-08-18
Last modified:2021-09-22
Method:ELECTRON MICROSCOPY (4.29 Å)
Cite:Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Mol.Cell, 81, 2021
7LT3
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BU of 7lt3 by Molmil
NHEJ Long-range synaptic complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (30-MER), DNA (31-MER), ...
Authors:He, Y, Chen, S.
Deposit date:2021-02-18
Release date:2021-04-14
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural basis of long-range to short-range synaptic transition in NHEJ.
Nature, 593, 2021
7LSY
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BU of 7lsy by Molmil
NHEJ Short-range synaptic complex
Descriptor: DNA (26-MER), DNA (5'-D(P*CP*AP*AP*TP*GP*AP*AP*AP*CP*GP*GP*AP*AP*CP*AP*GP*TP*CP*AP*G)-3'), DNA (5'-D(P*GP*TP*TP*CP*TP*TP*AP*GP*TP*AP*TP*AP*TP*A)-3'), ...
Authors:He, Y, Chen, S.
Deposit date:2021-02-18
Release date:2021-04-14
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (8.4 Å)
Cite:Structural basis of long-range to short-range synaptic transition in NHEJ.
Nature, 593, 2021
7AXZ
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BU of 7axz by Molmil
Ku70/80 complex apo form
Descriptor: X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6
Authors:Hnizda, A, Tesina, P, Novak, P, Blundell, T.L.
Deposit date:2020-11-10
Release date:2021-02-10
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:SAP domain forms a flexible part of DNA aperture in Ku70/80.
Febs J., 288, 2021
7K0Y
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BU of 7k0y by Molmil
Cryo-EM structure of activated-form DNA-PK (complex VI)
Descriptor: DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ...
Authors:Chen, X, Gellert, M, Yang, W.
Deposit date:2020-09-06
Release date:2021-01-06
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure of an activated DNA-PK and its implications for NHEJ.
Mol.Cell, 81, 2021

 

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PDB entries from 2024-03-27

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