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8STE
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BU of 8ste by Molmil
Cryo-EM structure of NKCC1 Fu_CTD
Descriptor: 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, Solute carrier family 12 member 2
Authors:Moseng, M.A.
Deposit date:2023-05-10
Release date:2023-05-17
Last modified:2023-05-31
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
8FHT
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BU of 8fht by Molmil
Cryo-EM structure of human NCC
Descriptor: CHLORIDE ION, SODIUM ION, Solute carrier family 12 member 3
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-15
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
8FHR
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BU of 8fhr by Molmil
Cryo-EM structure of human NCC (class 3-3)
Descriptor: Polythiazide, SODIUM ION, Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-14
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
8FHQ
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BU of 8fhq by Molmil
Cryo-EM structure of human NCC (class 3-2)
Descriptor: Polythiazide, SODIUM ION, Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-14
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
8FHP
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BU of 8fhp by Molmil
Cryo-EM structure of human NCC (class 3-1)
Descriptor: Polythiazide, SODIUM ION, Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-14
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
8FHO
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BU of 8fho by Molmil
Cryo-EM structure of human NCC (class 1)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Polythiazide, SODIUM ION, ...
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-14
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
8FHN
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BU of 8fhn by Molmil
Cryo-EM structure of human NCC (class 2)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Polythiazide, Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-14
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
7YG1
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BU of 7yg1 by Molmil
Cryo-EM structure of the C-terminal domain of the human sodium-chloride cotransporter
Descriptor: Solute carrier family 12 member 3
Authors:Nan, J, Yang, X.M, Shan, Z.Y, Yuan, Y.F, Zhang, Y.Q.
Deposit date:2022-07-09
Release date:2022-11-23
Method:ELECTRON MICROSCOPY (3.77 Å)
Cite:Cryo-EM structure of the human sodium-chloride cotransporter NCC.
Sci Adv, 8, 2022
7YG0
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BU of 7yg0 by Molmil
Cryo-EM structure of human sodium-chloride cotransporter
Descriptor: Solute carrier family 12 member 3
Authors:Nan, J, Yang, X.M, Shan, Z.Y, Yuan, Y.F, Zhang, Y.Q.
Deposit date:2022-07-09
Release date:2022-11-23
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Cryo-EM structure of the human sodium-chloride cotransporter NCC.
Sci Adv, 8, 2022
7Y6I
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BU of 7y6i by Molmil
Cryo-EM structure of human sodium-chloride cotransporter
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Nan, J, Yang, X, Shan, Z, Yuan, Y, Zhang, Y.Q.
Deposit date:2022-06-20
Release date:2022-11-23
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Cryo-EM structure of the human sodium-chloride cotransporter NCC.
Sci Adv, 8, 2022
7ZGO
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BU of 7zgo by Molmil
Cryo-EM structure of human NKCC1 (TM domain)
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, ...
Authors:Nissen, P, Fenton, R, Neumann, C, Lindtoft Rosenbaek, L, Kock Flygaard, R, Habeck, M, Lykkegaard Karlsen, J, Wang, Y, Lindorff-Larsen, K, Gad, H, Hartmann, R, Lyons, J.
Deposit date:2022-04-04
Release date:2022-10-05
Last modified:2023-04-19
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity.
Embo J., 41, 2022
7SFL
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BU of 7sfl by Molmil
Human NKCC1 state Fu-II
Descriptor: 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, Solute carrier family 12 member 2
Authors:Moseng, M.A.
Deposit date:2021-10-04
Release date:2022-09-28
Last modified:2023-05-31
Method:ELECTRON MICROSCOPY (3.87 Å)
Cite:Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
7SMP
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BU of 7smp by Molmil
CryoEM structure of NKCC1 Bu-I
Descriptor: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, POTASSIUM ION, Solute carrier family 12 member 2
Authors:Moseng, M.A.
Deposit date:2021-10-26
Release date:2022-09-28
Last modified:2023-05-31
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
7N3N
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BU of 7n3n by Molmil
CryoEM structure of human NKCC1 state Fu-I
Descriptor: 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, Solute carrier family 12 member 2
Authors:Moseng, M.A.
Deposit date:2021-06-01
Release date:2022-09-28
Last modified:2023-05-31
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
7MXO
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BU of 7mxo by Molmil
CryoEM structure of human NKCC1
Descriptor: CHLORIDE ION, POTASSIUM ION, Solute carrier family 12 member 2
Authors:Moseng, M.A.
Deposit date:2021-05-19
Release date:2022-09-28
Last modified:2023-05-31
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
7TTI
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BU of 7tti by Molmil
Human KCC1 bound with VU0463271 In an outward-open state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-cyclopropyl-N-(4-methyl-1,3-thiazol-2-yl)-2-[(6-phenylpyridazin-3-yl)sulfanyl]acetamide, Solute carrier family 12 member 4
Authors:Zhao, Y.X, Cao, E.H.
Deposit date:2022-02-01
Release date:2022-06-29
Last modified:2022-07-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the human cation-chloride cotransport KCC1 in an outward-open state.
Proc.Natl.Acad.Sci.USA, 119, 2022
7TTH
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BU of 7tth by Molmil
Human potassium-chloride cotransporter 1 in inward-open state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, POTASSIUM ION, Solute carrier family 12 member 4
Authors:Zhao, Y.X, Cao, E.H.
Deposit date:2022-02-01
Release date:2022-06-29
Last modified:2022-07-13
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structure of the human cation-chloride cotransport KCC1 in an outward-open state.
Proc.Natl.Acad.Sci.USA, 119, 2022
7S1Z
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BU of 7s1z by Molmil
Cryo-EM structure of Human NKCC1 K289NA492EL671C
Descriptor: Solute carrier family 12 member 2
Authors:Zhao, Y.X, Cao, E.H.
Deposit date:2021-09-02
Release date:2022-05-25
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
7S1X
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BU of 7s1x by Molmil
Cryo-EM structure of human NKCC1 K289NA492EL671C bound with bumetanide
Descriptor: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, CHLORIDE ION, POTASSIUM ION, ...
Authors:Zhao, Y.X, Cao, E.H.
Deposit date:2021-09-02
Release date:2022-05-25
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
7S1Y
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BU of 7s1y by Molmil
Cryo-EM structure of human NKCC1 K289NA492E bound with bumetanide
Descriptor: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, CHLORIDE ION, POTASSIUM ION, ...
Authors:Zhao, Y.X, Cao, E.h.
Deposit date:2021-09-02
Release date:2022-05-25
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
7NGB
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BU of 7ngb by Molmil
Structure of Wild-Type Human Potassium Chloride Transporter KCC3 in NaCl (LMNG/CHS)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Solute carrier family 12 member 6, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Chi, G, Man, H, Pike, A.C.W, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Abrusci, P, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, Duerr, K.L.
Deposit date:2021-02-09
Release date:2021-06-09
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021
7AIP
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BU of 7aip by Molmil
Structure of Human Potassium Chloride Transporter KCC1 in NaCl (Reference Map)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ebenhoch, R, Chi, G, Man, H, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Liko, I, Tehan, B.G, Almeida, F.G, Elkins, J, Singh, N.K, Abrusci, P, Arrowsmith, C.H, Tang, H, Robinson, C.V, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, Duerr, K.L, Structural Genomics Consortium (SGC)
Deposit date:2020-09-28
Release date:2021-06-02
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021
7AIO
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BU of 7aio by Molmil
Structure of Human Potassium Chloride Transporter KCC3 S45D/T940D/T997D in NaCl (Subclass)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 12 member 6, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Chi, G, Man, H, Ebenhoch, R, Reggiano, G, Pike, A.C.W, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, DiMaio, F, Duerr, K.L, Structural Genomics Consortium (SGC)
Deposit date:2020-09-28
Release date:2021-06-02
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021
7AIN
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BU of 7ain by Molmil
Structure of Human Potassium Chloride Transporter KCC3 S45D/T940D/T997D in NaCl (Reference Map)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Solute carrier family 12 member 6, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Chi, G, Man, H, Ebenhoch, R, Reggiano, G, Pike, A.C.W, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, DiMaio, F, Duerr, K.L, Structural Genomics Consortium (SGC)
Deposit date:2020-09-28
Release date:2021-06-02
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021
7AIQ
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BU of 7aiq by Molmil
Structure of Human Potassium Chloride Transporter KCC1 in NaCl (Subclass 1)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Solute carrier family 12 member 4, ...
Authors:Ebenhoch, R, Chi, G, Man, H, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Liko, I, Tehan, B.G, Almeida, F.G, Arrowsmith, C.H, Tang, H, Robinson, C.V, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, Duerr, K.L, Structural Genomics Consortium (SGC)
Deposit date:2020-09-28
Release date:2021-06-02
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021

 

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